Gene Page: DDC

Summary ?
GeneID1644
SymbolDDC
SynonymsAADC
Descriptiondopa decarboxylase
ReferenceMIM:107930|HGNC:HGNC:2719|Ensembl:ENSG00000132437|HPRD:00145|Vega:OTTHUMG00000023353
Gene typeprotein-coding
Map location7p12.2
Pascal p-value0.124
Fetal beta-0.709
eGeneMyers' cis & trans
SupportDOPAMINE
SEROTONIN

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs12066114chr119792526DDC16440.17trans
rs17130103chr188150541DDC16440.09trans
rs4846645chr1220595080DDC16440.19trans
rs6666913chr1237092144DDC16440.01trans
rs13403353chr2144067716DDC16440.14trans
rs7609917chr376094301DDC16440.19trans
rs2324466chr376100753DDC16440.01trans
rs17013713chr376105150DDC16449.706E-4trans
rs17013722chr376107656DDC16440.01trans
rs17013724chr376107684DDC16440.01trans
rs133264240DDC16440.16trans
rs11127757chr382043061DDC16440.18trans
rs7619146chr382098527DDC16440.15trans
rs9986296chr53199318DDC16440.01trans
rs200470chr627762186DDC16440.12trans
rs839777chr627909656DDC16440.13trans
rs149898chr627958071DDC16440.13trans
rs156742chr627963191DDC16440.13trans
rs175955chr628059733DDC16440.13trans
rs1225593chr628150518DDC16440.13trans
rs195749chr637253745DDC16440.01trans
rs992435chr797050802DDC16440.17trans
rs16920368chr855392852DDC16440.13trans
rs16927318chr862365911DDC16440.03trans
rs180038chr9101514415DDC16440.11trans
rs4742740chr9101524552DDC16440.05trans
rs2069410chr1256364644DDC16448.493E-4trans
rs17834315chr1337991091DDC16440trans
rs341395chr1561127355DDC16440.1trans
rs17798004chr1870665382DDC16440.19trans
rs17736134chr1870665805DDC16440.18trans
rs2469060chr1870673106DDC16440.18trans
rs409642chr2054250273DDC16440.03trans
rs5920627chrX97385064DDC16440.13trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MED130.960.97
MED10.960.97
CNOT60.960.96
AP1GBP10.960.98
AFF40.960.96
LATS10.960.96
PRKDC0.960.97
ZNF518B0.950.97
PBRM10.950.96
NCOA30.950.96
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.70-0.86
FXYD1-0.70-0.86
MT-CO2-0.70-0.87
IFI27-0.68-0.85
AF347015.27-0.68-0.83
AIFM3-0.68-0.74
AF347015.33-0.68-0.82
S100B-0.68-0.80
HIGD1B-0.67-0.85
HLA-F-0.67-0.73

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004058aromatic-L-amino-acid decarboxylase activityIDA16338639 
GO:0005515protein bindingIPI12864730 
GO:0016829lyase activityIEA-
GO:0016831carboxy-lyase activityIEA-
GO:0030170pyridoxal phosphate bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006519cellular amino acid and derivative metabolic processIEA-
GO:0019752carboxylic acid metabolic processIEA-
GO:0042423catecholamine biosynthetic processIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG HISTIDINE METABOLISM 2919All SZGR 2.0 genes in this pathway
KEGG TYROSINE METABOLISM 4230All SZGR 2.0 genes in this pathway
KEGG PHENYLALANINE METABOLISM 1812All SZGR 2.0 genes in this pathway
KEGG TRYPTOPHAN METABOLISM 4033All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200136All SZGR 2.0 genes in this pathway
REACTOME AMINE DERIVED HORMONES 1512All SZGR 2.0 genes in this pathway
IGARASHI ATF4 TARGETS DN 9065All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN UP 184125All SZGR 2.0 genes in this pathway
RODRIGUES NTN1 TARGETS DN 158102All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557331All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326213All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261153All SZGR 2.0 genes in this pathway
DIERICK SEROTONIN FUNCTION GENES 66All SZGR 2.0 genes in this pathway
JEON SMAD6 TARGETS DN 1914All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 2 11476All SZGR 2.0 genes in this pathway
NELSON RESPONSE TO ANDROGEN DN 1914All SZGR 2.0 genes in this pathway
SMITH LIVER CANCER 4527All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
ABBUD LIF SIGNALING 1 DN 2617All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
RORIE TARGETS OF EWSR1 FLI1 FUSION DN 3023All SZGR 2.0 genes in this pathway
KUNINGER IGF1 VS PDGFB TARGETS UP 8251All SZGR 2.0 genes in this pathway
HARRIS BRAIN CANCER PROGENITORS 4423All SZGR 2.0 genes in this pathway
LEIN MIDBRAIN MARKERS 8255All SZGR 2.0 genes in this pathway
YEGNASUBRAMANIAN PROSTATE CANCER 12860All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP 12589All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA E2 11865All SZGR 2.0 genes in this pathway
SMID BREAST CANCER ERBB2 UP 14783All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS DN 14985All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549316All SZGR 2.0 genes in this pathway
SERVITJA ISLET HNF1A TARGETS DN 10971All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157105All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244157All SZGR 2.0 genes in this pathway
BRIDEAU IMPRINTED GENES 6347All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway