Gene Page: ACAN

Summary
GeneID  176
Symbol  ACAN
Synonyms  AGC1|AGCAN|CSPG1|CSPGCP|MSK16|SEDK
Description  aggrecan
See related  HGNC:319|MIM:155760|HPRD:01123|
Locus tag  -
Gene type  protein-coding
Map location  15q26.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005529sugar bindingIEA-
GO:0005540hyaluronic acid bindingISS1569188 
GO:0005515protein bindingIEA-
GO:0030021extracellular matrix structural constituent conferring compression resistanceISS1569188 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001501skeletal system developmentNAS1569188 
GO:0001502cartilage condensationIEA-
GO:0007155cell adhesionIEA-
GO:0006508proteolysisNAS1569188 
GO:0030166proteoglycan biosynthetic processIEA-
GO:0030199collagen fibril organizationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005604basement membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
FBLN1FBLNfibulin 1-HPRD,BioGRID10400671 
FBLN2-fibulin 2-HPRD,BioGRID11038354 
HAPLN1CRTL1hyaluronan and proteoglycan link protein 1-HPRD12888576 
LUMLDC | SLRR2Dlumican-HPRD,BioGRID15505028 
TNFAIP6TSG-6 | TSG6tumor necrosis factor, alpha-induced protein 6-HPRD,BioGRID9654129 
TNRMGC149328 | TN-Rtenascin R (restrictin, janusin)-HPRD,BioGRID11038354 
VCANCSPG2 | DKFZp686K06110 | ERVR | PG-M | WGN | WGN1versicanAffinity Capture-Western
Reconstituted Complex		BioGRID12888576 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_KERATAN_SULFATE_BIOSYNTHESIS 2618All SZGR genes in this pathway
REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM 3021All SZGR genes in this pathway
REACTOME_KERATAN_SULFATE_DEGRADATION 117All SZGR genes in this pathway
REACTOME_GLYCOSAMINOGLYCAN_METABOLISM 11169All SZGR genes in this pathway
REACTOME_METABOLISM_OF_CARBOHYDRATES 247154All SZGR genes in this pathway
CORRE_MULTIPLE_MYELOMA_DN 6241All SZGR genes in this pathway
DARWICHE_SKIN_TUMOR_PROMOTER_UP 14296All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_LOW_UP 162104All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_UP 147101All SZGR genes in this pathway
DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP 146104All SZGR genes in this pathway
LIEN_BREAST_CARCINOMA_METAPLASTIC 3525All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_6HR_DN 2113All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
YAGUE_PRETUMOR_DRUG_RESISTANCE_DN 1311All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 349234All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME2_AND_H3K27ME3 5935All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 210148All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_1HR_DN 108All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_10HR_DN 3025All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
NABA_PROTEOGLYCANS 3523All SZGR genes in this pathway
NABA_CORE_MATRISOME 275148All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/506273279m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-133284290m8hsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
miR-242935m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-339298304m8hsa-miR-339UCCCUGUCCUCCAGGAGCUCA
miR-3748418481A,m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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