Gene Page: DOCK2

Summary ?
GeneID1794
SymbolDOCK2
SynonymsIMD40
Descriptiondedicator of cytokinesis 2
ReferenceMIM:603122|HGNC:HGNC:2988|Ensembl:ENSG00000134516|HPRD:09121|Vega:OTTHUMG00000130437
Gene typeprotein-coding
Map location5q35.1
Pascal p-value0.037
Sherlock p-value0.01
Fetal beta-0.168
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.0276 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg233385035169064530DOCK22.795E-4-0.2760.039DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PTPRK0.650.76
TNFAIP20.650.66
GRIP20.620.57
ZNF1850.610.53
PTPN130.610.74
ARHGAP210.610.66
LRRN30.600.57
KDM4C0.600.63
SMPDL3A0.590.60
SPINT10.590.41
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.44-0.43
S100A16-0.44-0.44
METRN-0.43-0.47
IFI27-0.43-0.40
CST3-0.43-0.43
REEP6-0.42-0.41
PLA2G5-0.42-0.45
AF347015.31-0.42-0.39
ENHO-0.42-0.48
IL32-0.41-0.47

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005085guanyl-nucleotide exchange factor activityIEA-
GO:0005506iron ion bindingIEA-
GO:0005515protein bindingIPI12134158 
GO:0020037heme bindingIEA-
GO:0009055electron carrier activityIEA-
GO:0042608T cell receptor bindingIDA12176041 
GO:0030676Rac guanyl-nucleotide exchange factor activityIDA10559471 
GO:0030675Rac GTPase activator activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001771formation of immunological synapseIEASynap (GO term level: 6)-
GO:0001766membrane raft polarizationIEA-
GO:0001768establishment of T cell polarityIEA-
GO:0007010cytoskeleton organizationIEA-
GO:0006935chemotaxisIEA-
GO:0030036actin cytoskeleton organizationTAS12176041 
GO:0048247lymphocyte chemotaxisISS11518968 
GO:0045060negative thymic T cell selectionIEA-
GO:0045059positive thymic T cell selectionIEA-
GO:0046633alpha-beta T cell proliferationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0012505endomembrane systemIEA-
GO:0005829cytosolEXP14737186 
GO:0005856cytoskeletonIEA-
GO:0005737cytoplasmIEA-
GO:0016020membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CHEMOKINE SIGNALING PATHWAY 190128All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 9771All SZGR 2.0 genes in this pathway
PID IL8 CXCR2 PATHWAY 3426All SZGR 2.0 genes in this pathway
PID RAC1 REG PATHWAY 3825All SZGR 2.0 genes in this pathway
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 132101All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207122All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS 13281All SZGR 2.0 genes in this pathway
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS 2819All SZGR 2.0 genes in this pathway
WINTER HYPOXIA DN 5230All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423283All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392251All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358245All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
MORI LARGE PRE BII LYMPHOCYTE DN 5839All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP 8758All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION DN 8757All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT UP 8961All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487303All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268157All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA RADIATION 8159All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226164All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA E2 11865All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE 200115All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288168All SZGR 2.0 genes in this pathway
GYORFFY MITOXANTRONE RESISTANCE 5735All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP 7646All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN 321200All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 10HR DN 3025All SZGR 2.0 genes in this pathway