Gene Page: AGT

Summary
GeneID  183
Symbol  AGT
Synonyms  ANHU|FLJ92595|FLJ97926|SERPINA8
Description  angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
See related  HGNC:333|MIM:106150|Ensembl:ENSG00000135744|HPRD:00106|
Locus tag  -
Gene type  protein-coding
Map location  1q42-q43
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005179hormone activityIC1378723 
GO:0005179hormone activityISS-
GO:0004867serine-type endopeptidase inhibitor activityTAS3397061 
GO:0008083growth factor activityTAS10406457 
GO:0031702type 1 angiotensin receptor bindingIEA-
GO:0031703type 2 angiotensin receptor bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008065establishment of blood-nerve barrierIEABrain (GO term level: 7)-
GO:0002035brain renin-angiotensin systemIEABrain (GO term level: 12)-
GO:0048143astrocyte activationIEAastrocyte (GO term level: 11)-
GO:0043524negative regulation of neuron apoptosisIEAneuron (GO term level: 9)-
GO:0001568blood vessel developmentIEA-
GO:0001558regulation of cell growthNAS17159080 
GO:0001543ovarian follicle ruptureIEA-
GO:0001658ureteric bud branchingIEA-
GO:0001998angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressureIEA-
GO:0001999renal response to blood flow during renin-angiotensin regulation of systemic arterial blood pressureIEA-
GO:0002018renin-angiotensin regulation of aldosterone productionIEA-
GO:0002019regulation of renal output by angiotensinIEA-
GO:0003078regulation of natriuresisNAS17159080 
GO:0001822kidney developmentIEA-
GO:0001974blood vessel remodelingTAS10406457 
GO:0001819positive regulation of cytokine productionTAS17906677 
GO:0007200G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)NAS17159080 
GO:0007160cell-matrix adhesionIEA-
GO:0007199G-protein signaling, coupled to cGMP nucleotide second messengerTAS17159080 
GO:0007267cell-cell signalingTAS8513325 
GO:0007263nitric oxide mediated signal transductionTAS17159080 
GO:0010595positive regulation of endothelial cell migrationIDA15652490 
GO:0008285negative regulation of cell proliferationIEA-
GO:0009409response to coldIEA-
GO:0010613positive regulation of cardiac muscle hypertrophyISS-
GO:0006800oxygen and reactive oxygen species metabolic processTAS17159080 |17906677 
GO:0014068positive regulation of phosphoinositide 3-kinase cascadeIDA15652490 
GO:0043065positive regulation of apoptosisIDA10406457 
GO:0051092positive regulation of NF-kappaB transcription factor activityTAS17906677 
GO:0014873response to muscle activity involved in regulation of muscle adaptationISS-
GO:0030432peristalsisIEA-
GO:0042445hormone metabolic processIEA-
GO:0042756drinking behaviorIEA-
GO:0040018positive regulation of multicellular organism growthIEA-
GO:0019229regulation of vasoconstrictionNAS17159080 
GO:0033864positive regulation of NAD(P)H oxidase activityTAS17159080 
GO:0051145smooth muscle cell differentiationIEA-
GO:0043410positive regulation of MAPKKK cascadeIEA-
GO:0030198extracellular matrix organizationIEA-
GO:0045742positive regulation of epidermal growth factor receptor signaling pathwayIDA15652490 
GO:0045723positive regulation of fatty acid biosynthetic processIEA-
GO:0048146positive regulation of fibroblast proliferationISS-
GO:0050729positive regulation of inflammatory responseTAS17159080 |17906677 
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIDA15652490 
GO:0046622positive regulation of organ growthIEA-
GO:0048659smooth muscle cell proliferationIEA-
GO:0051387negative regulation of nerve growth factor receptor signaling pathwayIDA10406457 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS14718574 
GO:0005615extracellular spaceIEA-
GO:0005625soluble fractionTAS6089875 
GO:0005737cytoplasmIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AGTR1AG2S | AGTR1A | AGTR1B | AT1 | AT1B | AT1R | AT2R1 | AT2R1A | AT2R1B | HAT1Rangiotensin II receptor, type 1-HPRD11709400 
AGTR2AT2 | ATGR2 | MRX88angiotensin II receptor, type 2-HPRD11709400 
DNPEPASPEP | DAPaspartyl aminopeptidase-HPRD12895663 
EWSR1EWSEwing sarcoma breakpoint region 1Two-hybridBioGRID16189514 
MAS1MAS | MGC119966MAS1 oncogene-HPRD12829792 
MEP1APPHAmeprin A, alpha (PABA peptide hydrolase)-HPRD11278902 
PRG2BMPG | MBP | MBP1 | MGC14537proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)-HPRD7539791 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_RENIN_ANGIOTENSIN_SYSTEM 1710All SZGR genes in this pathway
BIOCARTA_AT1R_PATHWAY 3628All SZGR genes in this pathway
BIOCARTA_ACE2_PATHWAY 137All SZGR genes in this pathway
BIOCARTA_BIOPEPTIDES_PATHWAY 4535All SZGR genes in this pathway
BIOCARTA_NFAT_PATHWAY 5645All SZGR genes in this pathway
BIOCARTA_CARDIACEGF_PATHWAY 1816All SZGR genes in this pathway
PID_PRL_SIGNALING_EVENTS_PATHWAY 2317All SZGR genes in this pathway
PID_AP1_PATHWAY 7060All SZGR genes in this pathway
REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 10472All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS 188108All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 184116All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 195114All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 168115All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_UP 13378All SZGR genes in this pathway
HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_1_UP 3618All SZGR genes in this pathway
HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_2NM_UP 8157All SZGR genes in this pathway
DAUER_STAT3_TARGETS_UP 4935All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_DN 5142All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
ZEILSTRA_CD44_TARGETS_UP 75All SZGR genes in this pathway
OKUMURA_INFLAMMATORY_RESPONSE_LPS 183115All SZGR genes in this pathway
STOSSI_RESPONSE_TO_ESTRADIOL 5035All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
NADLER_OBESITY_DN 4834All SZGR genes in this pathway
RADMACHER_AML_PROGNOSIS 7852All SZGR genes in this pathway
URS_ADIPOCYTE_DIFFERENTIATION_UP 7451All SZGR genes in this pathway
MARCHINI_TRABECTEDIN_RESISTANCE_UP 2116All SZGR genes in this pathway
HENDRICKS_SMARCA4_TARGETS_UP 5635All SZGR genes in this pathway
RUAN_RESPONSE_TO_TNF_DN 8450All SZGR genes in this pathway
BURTON_ADIPOGENESIS_5 12678All SZGR genes in this pathway
LU_AGING_BRAIN_UP 262186All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_24HR 4330All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_UP 8458All SZGR genes in this pathway
SAFFORD_T_LYMPHOCYTE_ANERGY 8754All SZGR genes in this pathway
LI_ADIPOGENESIS_BY_ACTIVATED_PPARG 1712All SZGR genes in this pathway
GERHOLD_ADIPOGENESIS_UP 4940All SZGR genes in this pathway
LEIN_MIDBRAIN_MARKERS 8255All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN 354216All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SCHRAETS_MLL_TARGETS_DN 3324All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_UP 293203All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_DN 222141All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA2_DN 8051All SZGR genes in this pathway
MIKKELSEN_NPC_LCP_WITH_H3K4ME3 5834All SZGR genes in this pathway
GERHOLD_RESPONSE_TO_TZD_DN 1311All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
VERNOCHET_ADIPOGENESIS 1911All SZGR genes in this pathway
WANG_MLL_TARGETS 289188All SZGR genes in this pathway
NABA_ECM_REGULATORS 238125All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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