Gene Page: AGT

Summary ?
GeneID183
SymbolAGT
SynonymsANHU|SERPINA8
Descriptionangiotensinogen
ReferenceMIM:106150|HGNC:HGNC:333|Ensembl:ENSG00000135744|HPRD:00106|Vega:OTTHUMG00000037757
Gene typeprotein-coding
Map location1q42.2
Fetal beta-2.857
eGeneCaudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Nucleus accumbens basal ganglia
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1538974chr1231828595AGT1830.17cis
rs11583715chr1231829038AGT1830.17cis
rs16938766chr874949940AGT1830.19trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005179hormone activityIC1378723 
GO:0005179hormone activityISS-
GO:0004867serine-type endopeptidase inhibitor activityTAS3397061 
GO:0008083growth factor activityTAS10406457 
GO:0031702type 1 angiotensin receptor bindingIEA-
GO:0031703type 2 angiotensin receptor bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008065establishment of blood-nerve barrierIEABrain (GO term level: 7)-
GO:0002035brain renin-angiotensin systemIEABrain (GO term level: 12)-
GO:0048143astrocyte activationIEAastrocyte (GO term level: 11)-
GO:0043524negative regulation of neuron apoptosisIEAneuron (GO term level: 9)-
GO:0001568blood vessel developmentIEA-
GO:0001558regulation of cell growthNAS17159080 
GO:0001543ovarian follicle ruptureIEA-
GO:0001658ureteric bud branchingIEA-
GO:0001998angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressureIEA-
GO:0001999renal response to blood flow during renin-angiotensin regulation of systemic arterial blood pressureIEA-
GO:0002018renin-angiotensin regulation of aldosterone productionIEA-
GO:0002019regulation of renal output by angiotensinIEA-
GO:0003078regulation of natriuresisNAS17159080 
GO:0001822kidney developmentIEA-
GO:0001974blood vessel remodelingTAS10406457 
GO:0001819positive regulation of cytokine productionTAS17906677 
GO:0007200G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)NAS17159080 
GO:0007160cell-matrix adhesionIEA-
GO:0007199G-protein signaling, coupled to cGMP nucleotide second messengerTAS17159080 
GO:0007267cell-cell signalingTAS8513325 
GO:0007263nitric oxide mediated signal transductionTAS17159080 
GO:0010595positive regulation of endothelial cell migrationIDA15652490 
GO:0008285negative regulation of cell proliferationIEA-
GO:0009409response to coldIEA-
GO:0010613positive regulation of cardiac muscle hypertrophyISS-
GO:0006800oxygen and reactive oxygen species metabolic processTAS17159080 |17906677 
GO:0014068positive regulation of phosphoinositide 3-kinase cascadeIDA15652490 
GO:0043065positive regulation of apoptosisIDA10406457 
GO:0051092positive regulation of NF-kappaB transcription factor activityTAS17906677 
GO:0014873response to muscle activity involved in regulation of muscle adaptationISS-
GO:0030432peristalsisIEA-
GO:0042445hormone metabolic processIEA-
GO:0042756drinking behaviorIEA-
GO:0040018positive regulation of multicellular organism growthIEA-
GO:0019229regulation of vasoconstrictionNAS17159080 
GO:0033864positive regulation of NAD(P)H oxidase activityTAS17159080 
GO:0051145smooth muscle cell differentiationIEA-
GO:0043410positive regulation of MAPKKK cascadeIEA-
GO:0030198extracellular matrix organizationIEA-
GO:0045742positive regulation of epidermal growth factor receptor signaling pathwayIDA15652490 
GO:0045723positive regulation of fatty acid biosynthetic processIEA-
GO:0048146positive regulation of fibroblast proliferationISS-
GO:0050729positive regulation of inflammatory responseTAS17159080 |17906677 
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIDA15652490 
GO:0046622positive regulation of organ growthIEA-
GO:0048659smooth muscle cell proliferationIEA-
GO:0051387negative regulation of nerve growth factor receptor signaling pathwayIDA10406457 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS14718574 
GO:0005615extracellular spaceIEA-
GO:0005625soluble fractionTAS6089875 
GO:0005737cytoplasmIDA18029348 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG RENIN ANGIOTENSIN SYSTEM 1710All SZGR 2.0 genes in this pathway
BIOCARTA AT1R PATHWAY 3628All SZGR 2.0 genes in this pathway
BIOCARTA ACE2 PATHWAY 137All SZGR 2.0 genes in this pathway
BIOCARTA BIOPEPTIDES PATHWAY 4535All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY 5645All SZGR 2.0 genes in this pathway
BIOCARTA CARDIACEGF PATHWAY 1816All SZGR 2.0 genes in this pathway
PID PRL SIGNALING EVENTS PATHWAY 2317All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY 7060All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION 10472All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205136All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188108All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184116All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195114All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 168115All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL UP 13378All SZGR 2.0 genes in this pathway
HERNANDEZ MITOTIC ARREST BY DOCETAXEL 1 UP 3618All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM UP 8157All SZGR 2.0 genes in this pathway
DAUER STAT3 TARGETS UP 4935All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 2 DN 5142All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
ZEILSTRA CD44 TARGETS UP 75All SZGR 2.0 genes in this pathway
OKUMURA INFLAMMATORY RESPONSE LPS 183115All SZGR 2.0 genes in this pathway
STOSSI RESPONSE TO ESTRADIOL 5035All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
NADLER OBESITY DN 4834All SZGR 2.0 genes in this pathway
RADMACHER AML PROGNOSIS 7852All SZGR 2.0 genes in this pathway
URS ADIPOCYTE DIFFERENTIATION UP 7451All SZGR 2.0 genes in this pathway
MARCHINI TRABECTEDIN RESISTANCE UP 2116All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS UP 5635All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TNF DN 8450All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 5 12678All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262186All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 24HR 4330All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM UP 8458All SZGR 2.0 genes in this pathway
SAFFORD T LYMPHOCYTE ANERGY 8754All SZGR 2.0 genes in this pathway
LI ADIPOGENESIS BY ACTIVATED PPARG 1712All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS UP 4940All SZGR 2.0 genes in this pathway
LEIN MIDBRAIN MARKERS 8255All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354216All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374247All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
SCHRAETS MLL TARGETS DN 3324All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293203All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222141All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA2 DN 8051All SZGR 2.0 genes in this pathway
MIKKELSEN NPC LCP WITH H3K4ME3 5834All SZGR 2.0 genes in this pathway
GERHOLD RESPONSE TO TZD DN 1311All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
VERNOCHET ADIPOGENESIS 1911All SZGR 2.0 genes in this pathway
WANG MLL TARGETS 289188All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238125All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway