SZGR2

Summary ?

GeneID	1974
Symbol	EIF4A2
Synonyms	BM-010\|DDX2B\|EIF4A\|EIF4F\|eIF-4A-II\|eIF4A-II
Description	eukaryotic translation initiation factor 4A2
Reference	MIM:601102\|HGNC:HGNC:3284\|Ensembl:ENSG00000156976\|HPRD:03062\|Vega:OTTHUMG00000156564
Gene type	protein-coding
Map location	3q28
Pascal p-value	0.099
Sherlock p-value	0.002
Fetal beta	-0.338
eGene	Myers' cis & trans
Support	G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs7132043	chr12	80968399	EIF4A2	1974		0.09		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0003676	nucleic acid binding	IEA		-
GO:0003723	RNA binding	IEA		-
GO:0003743	translation initiation factor activity	IEA		-
GO:0003743	translation initiation factor activity	TAS		8521730
GO:0005515	protein binding	IPI		11408474
GO:0005524	ATP binding	IEA		-
GO:0016787	hydrolase activity	IEA		-
GO:0008026	ATP-dependent helicase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006446	regulation of translational initiation	TAS		8521730
GO:0006412	translation	IEA		-
GO:0044419	interspecies interaction between organisms	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		8449919 \|12588972
GO:0016281	eukaryotic translation initiation factor 4F complex	TAS		8521730

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ALPI	IAP	alkaline phosphatase, intestinal	Affinity Capture-MS	BioGRID	17353931
ATRX	ATR2 \| MGC2094 \| MRXHF1 \| RAD54 \| RAD54L \| SFM1 \| SHS \| XH2 \| XNP \| ZNF-HX	alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931
CD2BP2	FWP010 \| LIN1 \| Snu40 \| U5-52K	CD2 (cytoplasmic tail) binding protein 2	Affinity Capture-MS	BioGRID	17353931
CMBL	FLJ23617	carboxymethylenebutenolidase homolog (Pseudomonas)	Affinity Capture-MS	BioGRID	17353931
DDX3X	DBX \| DDX14 \| DDX3 \| HLP2	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	Affinity Capture-MS	BioGRID	17353931
EIF3A	EIF3 \| EIF3S10 \| KIAA0139 \| P167 \| TIF32 \| eIF3-p170 \| eIF3-theta \| p180 \| p185	eukaryotic translation initiation factor 3, subunit A	Affinity Capture-MS	BioGRID	17353931
EIF3D	EIF3S7 \| MGC126526 \| MGC17258 \| eIF3-p66 \| eIF3-zeta	eukaryotic translation initiation factor 3, subunit D	Affinity Capture-MS	BioGRID	17353931
EIF3EIP	EIF3S11 \| EIF3S6IP \| HSPC021 \| HSPC025 \| MSTP005	eukaryotic translation initiation factor 3, subunit E interacting protein	Affinity Capture-MS	BioGRID	17353931
EIF3H	EIF3S3 \| MGC102958 \| eIF3-gamma \| eIF3-p40	eukaryotic translation initiation factor 3, subunit H	Affinity Capture-MS	BioGRID	17353931
EIF3K	ARG134 \| EIF3-p28 \| EIF3S12 \| HSPC029 \| M9 \| MSTP001 \| PLAC-24 \| PLAC24 \| PRO1474 \| PTD001	eukaryotic translation initiation factor 3, subunit K	Affinity Capture-MS	BioGRID	17353931
EIF3M	B5 \| FLJ29030 \| GA17 \| PCID1 \| hfl-B5	eukaryotic translation initiation factor 3, subunit M	Affinity Capture-MS	BioGRID	17353931
EIF4E	CBP \| EIF4E1 \| EIF4EL1 \| EIF4F \| MGC111573	eukaryotic translation initiation factor 4E	Affinity Capture-MS	BioGRID	17353931
EIF4G1	DKFZp686A1451 \| EIF4F \| EIF4G \| p220	eukaryotic translation initiation factor 4 gamma, 1	Affinity Capture-MS	BioGRID	17353931
EIF4G1	DKFZp686A1451 \| EIF4F \| EIF4G \| p220	eukaryotic translation initiation factor 4 gamma, 1	-	HPRD	11408474
EIF4G2	AAG1 \| DAP5 \| FLJ41344 \| NAT1 \| p97	eukaryotic translation initiation factor 4 gamma, 2	Affinity Capture-MS	BioGRID	17353931
EIF4G3	eIF4GII	eukaryotic translation initiation factor 4 gamma, 3	Affinity Capture-MS	BioGRID	17353931
MYO1B	myr1	myosin IB	Affinity Capture-MS	BioGRID	17353931
P4HB	DSI \| ERBA2L \| GIT \| PDI \| PDIA1 \| PHDB \| PO4DB \| PO4HB \| PROHB	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide	Affinity Capture-MS	BioGRID	17353931
PABPC1	PAB1 \| PABP \| PABP1 \| PABPC2 \| PABPL1	poly(A) binding protein, cytoplasmic 1	Affinity Capture-MS	BioGRID	17353931
PDCD4	H731 \| MGC33046 \| MGC33047	programmed cell death 4 (neoplastic transformation inhibitor)	Affinity Capture-MS	BioGRID	17353931
PTPRS	PTPSIGMA	protein tyrosine phosphatase, receptor type, S	Affinity Capture-MS	BioGRID	17353931
RPS29	-	ribosomal protein S29	Affinity Capture-MS	BioGRID	17353931
SFRS17A	721P \| CCDC133 \| CXYorf3 \| DXYS155E \| MGC125365 \| MGC125366 \| MGC39904 \| XE7 \| XE7Y	splicing factor, arginine/serine-rich 17A	Affinity Capture-MS	BioGRID	17353931
SPAG9	FLJ13450 \| FLJ14006 \| FLJ26141 \| FLJ34602 \| HLC4 \| JLP \| KIAA0516 \| MGC117291 \| MGC14967 \| MGC74461 \| PHET \| PIG6	sperm associated antigen 9	Affinity Capture-MS	BioGRID	17353931
TPM3	FLJ41118 \| MGC14582 \| MGC3261 \| MGC72094 \| NEM1 \| OK/SW-cl.5 \| TM-5 \| TM3 \| TM30 \| TM30nm \| TPMsk3 \| TRK \| hscp30	tropomyosin 3	Affinity Capture-MS	BioGRID	17353931
VAC14	ArPIKfyve \| FLJ10305 \| FLJ36622 \| FLJ46582 \| MGC149815 \| MGC149816 \| TAX1BP2 \| TRX	Vac14 homolog (S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
BIOCARTA EIF PATHWAY	16	9	All SZGR 2.0 genes in this pathway
BIOCARTA MTOR PATHWAY	23	15	All SZGR 2.0 genes in this pathway
BIOCARTA EIF4 PATHWAY	24	19	All SZGR 2.0 genes in this pathway
REACTOME TRANSLATION	222	75	All SZGR 2.0 genes in this pathway
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	66	45	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	84	30	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS	518	242	All SZGR 2.0 genes in this pathway
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	176	51	All SZGR 2.0 genes in this pathway
REACTOME DEADENYLATION OF MRNA	22	14	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA	284	128	All SZGR 2.0 genes in this pathway
REACTOME DEADENYLATION DEPENDENT MRNA DECAY	48	29	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA	330	155	All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING	159	116	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN	526	357	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN	406	230	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION CCNE1	40	26	All SZGR 2.0 genes in this pathway
MYLLYKANGAS AMPLIFICATION HOT SPOT 7	8	6	All SZGR 2.0 genes in this pathway
ZHAN V2 LATE DIFFERENTIATION GENES	45	34	All SZGR 2.0 genes in this pathway
JIANG VHL TARGETS	138	91	All SZGR 2.0 genes in this pathway
MMS MOUSE LYMPH HIGH 4HRS UP	36	20	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
LEE AGING MUSCLE UP	45	33	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 2D UP	69	46	All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE E2	28	21	All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS	425	261	All SZGR 2.0 genes in this pathway
CHNG MULTIPLE MYELOMA HYPERPLOID UP	52	25	All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP	323	240	All SZGR 2.0 genes in this pathway
MOOTHA PGC	420	269	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN	181	97	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2	115	74	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-132/212	202	208	m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	202	208	m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-137	531	537	m8	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-145	504	510	m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-17-5p/20/93.mr/106/519.d	620	626	1A	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-181	596	602	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-183	567	573	1A	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-19	574	580	1A	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	574	580	1A	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-208	582	588	1A	hsa-miR-208	AUAAGACGAGCAAAAAGCUUGU
miR-217	22	28	m8	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU
miR-335	159	165	m8	hsa-miR-335^brain	UCAAGAGCAAUAACGAAAAAUGU
miR-377	499	505	1A	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-381	611	617	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-499	582	588	1A	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA
miR-543	597	604	1A,m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: EIF4A2