Gene Page: ALAS2

Summary ?
GeneID212
SymbolALAS2
SynonymsALAS-E|ALASE|ANH1|ASB|XLDPP|XLEPP|XLSA
Description5'-aminolevulinate synthase 2
ReferenceMIM:301300|HGNC:HGNC:397|Ensembl:ENSG00000158578|HPRD:02356|Vega:OTTHUMG00000021641
Gene typeprotein-coding
Map locationXp11.21
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2762819chr152798032ALAS22120.15trans
rs7538562chr159277182ALAS22120.04trans
rs2811849chr159300272ALAS22120.14trans
rs2811850chr159312340ALAS22120.14trans
rs2272792chr1166829521ALAS22121.638E-4trans
rs6543264chr2105270432ALAS22122.924E-5trans
rs12468303chr2181613256ALAS22120.11trans
rs16867364chr2181624945ALAS22120.2trans
rs6442062chr347243234ALAS22120.12trans
rs295432chr347361887ALAS22120trans
rs1545329chr495912889ALAS22128.034E-4trans
rs2120832chr495924906ALAS22120.02trans
rs1444920chr495925993ALAS22120.02trans
rs9326981chr5115320607ALAS22120.1trans
rs12524113chr638679547ALAS22125.033E-7trans
rs17712118chr670808553ALAS22120.1trans
rs9484130chr6138547963ALAS22120.04trans
rs6907613chr6138548270ALAS22120.09trans
rs11007270chr1029146063ALAS22120.16trans
rs266080chr1044833893ALAS22120.17trans
rs7488206chr1249784155ALAS22120.13trans
rs12422793chr12125892834ALAS22120.09trans
rs7323925chr1324217159ALAS22120.19trans
snp_a-17852450ALAS22120.05trans
rs4566169chr16911716ALAS22120.15trans
rs274094chr1624910476ALAS22120.15trans
rs6029091chr2039016259ALAS22120.11trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TELO20.900.89
ARVCF0.900.88
DTX10.900.89
WIZ0.890.89
FZR10.890.87
GLT25D10.890.87
ZNF4460.890.90
SARM10.880.86
RFX10.880.90
GTPBP30.880.87
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C5orf53-0.70-0.70
AF347015.31-0.68-0.74
AF347015.27-0.67-0.73
MT-CO2-0.65-0.72
AF347015.33-0.65-0.71
MT-CYB-0.63-0.70
S100B-0.63-0.67
ACOT13-0.62-0.65
AF347015.21-0.62-0.77
B2M-0.61-0.65

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG GLYCINE SERINE AND THREONINE METABOLISM 3126All SZGR 2.0 genes in this pathway
KEGG PORPHYRIN AND CHLOROPHYLL METABOLISM 4123All SZGR 2.0 genes in this pathway
BIOCARTA AHSP PATHWAY 136All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PORPHYRINS 147All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY UP 7841All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226132All SZGR 2.0 genes in this pathway
HAHTOLA SEZARY SYNDROM UP 9858All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329196All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK DN 7954All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514319All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357212All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA DN 6544All SZGR 2.0 genes in this pathway
WELCH GATA1 TARGETS 2212All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGG VS IGA DN 2616All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246180All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP 151103All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS MATURE CELL 293160All SZGR 2.0 genes in this pathway
KEEN RESPONSE TO ROSIGLITAZONE DN 10668All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE UP 14985All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346192All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE D7 DN 4022All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317177All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442263All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN 225124All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS DN 14985All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242146All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN 11674All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
VANDESLUIS NORMAL EMBRYOS DN 2513All SZGR 2.0 genes in this pathway
JUBAN TARGETS OF SPI1 AND FLI1 UP 11573All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157105All SZGR 2.0 genes in this pathway