Gene Page: MAPKBP1

Summary ?
GeneID23005
SymbolMAPKBP1
SynonymsJNKBP-1|JNKBP1
Descriptionmitogen-activated protein kinase binding protein 1
ReferenceMIM:616786|HGNC:HGNC:29536|Ensembl:ENSG00000137802|HPRD:17465|Vega:OTTHUMG00000160227
Gene typeprotein-coding
Map location15q15.1
Pascal p-value0.672
Sherlock p-value0.297
Fetal beta0.929
eGeneCaudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Nucleus accumbens basal ganglia
Myers' cis & trans
Meta
SupportCompositeSet
Darnell FMRP targets
Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenicClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16829545chr2151977407MAPKBP1230051.478E-16trans
rs3845734chr2171125572MAPKBP1230050.01trans
rs7584986chr2184111432MAPKBP1230052.881E-5trans
rs2183142chr4159232695MAPKBP1230050.07trans
rs170776chr4173276735MAPKBP1230050.13trans
rs1396222chr4173279496MAPKBP1230050.13trans
rs335993chr4173321789MAPKBP1230050.18trans
rs335980chr4173329784MAPKBP1230050.11trans
rs335982chr4173330945MAPKBP1230050.15trans
rs336016chr4173366576MAPKBP1230050.17trans
rs337984chr4173411662MAPKBP1230050.09trans
rs17762315chr576807576MAPKBP1230050.02trans
rs9461864chr633481468MAPKBP1230050.01trans
rs7787830chr798797019MAPKBP1230050.03trans
rs3118341chr925185518MAPKBP1230050.16trans
rs9406868chr925223372MAPKBP1230050.16trans
rs11139334chr984209393MAPKBP1230050.17trans
rs16955618chr1529937543MAPKBP1230052.07E-19trans
rs11873184chr181584081MAPKBP1230050.05trans
rs1041786chr2122617710MAPKBP1230050.17trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
WNK10.920.91
CLN80.880.89
SPTLC20.870.88
KIAA11470.850.88
USP540.850.82
DENND5A0.840.87
DST0.840.83
BBX0.840.81
AFF10.840.82
FAM55C0.830.86
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ST20-0.50-0.57
C1orf61-0.45-0.50
IL32-0.44-0.52
PFDN5-0.44-0.45
TIMM8B-0.43-0.45
C8orf59-0.42-0.45
C1orf54-0.42-0.50
SYCP3-0.42-0.51
AF347015.21-0.41-0.44
SERF2-0.41-0.45

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409268All SZGR 2.0 genes in this pathway
KONDO COLON CANCER HCP WITH H3K27ME1 2613All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BRAIN DN 8558All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP 7149All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518299All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN 157106All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND WITH H4K20ME1 MARK 14582All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784464All SZGR 2.0 genes in this pathway