Gene Page: PLCH1
Summary ?
| GeneID | 23007 |
| Symbol | PLCH1 |
| Synonyms | PLCL3 |
| Description | phospholipase C eta 1 |
| Reference | MIM:612835|HGNC:HGNC:29185|Ensembl:ENSG00000114805|HPRD:11438|Vega:OTTHUMG00000158477 |
| Gene type | protein-coding |
| Map location | 3q25.31 |
| Pascal p-value | 0.024 |
| Fetal beta | -0.045 |
| DMG | 1 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg01671681 | 3 | 155421735 | PLCH1 | 1.328E-4 | -0.436 | 0.03 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PPP1R12B | 0.80 | 0.83 |
| PHLPP2 | 0.80 | 0.85 |
| MYCBP2 | 0.80 | 0.85 |
| ASAP1 | 0.79 | 0.82 |
| ZC3H12B | 0.78 | 0.79 |
| CDC42BPA | 0.78 | 0.84 |
| KIAA1377 | 0.78 | 0.78 |
| C9orf4 | 0.78 | 0.76 |
| ROCK2 | 0.78 | 0.86 |
| TCP11L1 | 0.78 | 0.79 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ENHO | -0.51 | -0.60 |
| RHOC | -0.51 | -0.61 |
| C1orf54 | -0.49 | -0.61 |
| C1orf61 | -0.49 | -0.60 |
| AF347015.21 | -0.48 | -0.50 |
| DBI | -0.47 | -0.57 |
| VAMP5 | -0.47 | -0.55 |
| TLCD1 | -0.46 | -0.48 |
| GNG11 | -0.46 | -0.55 |
| S100A13 | -0.46 | -0.51 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP | 450 | 256 | All SZGR 2.0 genes in this pathway |
| TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN | 187 | 115 | All SZGR 2.0 genes in this pathway |
| GOZGIT ESR1 TARGETS DN | 781 | 465 | All SZGR 2.0 genes in this pathway |
| DELYS THYROID CANCER DN | 232 | 154 | All SZGR 2.0 genes in this pathway |
| FARMER BREAST CANCER APOCRINE VS LUMINAL | 326 | 213 | All SZGR 2.0 genes in this pathway |
| YANG BREAST CANCER ESR1 DN | 25 | 15 | All SZGR 2.0 genes in this pathway |
| CUI TCF21 TARGETS 2 UP | 428 | 266 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER LUMINAL B DN | 564 | 326 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL UP | 648 | 398 | All SZGR 2.0 genes in this pathway |
| HUANG DASATINIB RESISTANCE DN | 69 | 44 | All SZGR 2.0 genes in this pathway |
| BOYLAN MULTIPLE MYELOMA D CLUSTER UP | 27 | 19 | All SZGR 2.0 genes in this pathway |
| ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP | 289 | 184 | All SZGR 2.0 genes in this pathway |