SZGR2

Summary ?

GeneID	23054
Symbol	NCOA6
Synonyms	AIB3\|ASC2\|NRC\|PRIP\|RAP250\|TRBP
Description	nuclear receptor coactivator 6
Reference	MIM:605299\|HGNC:HGNC:15936\|Ensembl:ENSG00000198646\|HPRD:05599\|Vega:OTTHUMG00000032311
Gene type	protein-coding
Map location	20q11
Pascal p-value	0.017
Sherlock p-value	0.142
eGene	Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Nucleus accumbens basal ganglia Putamen basal ganglia
Support	CompositeSet Darnell FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	TSS distance	eQTL type
rs2024632	20	33465572	NCOA6	ENSG00000198646.9	5.368E-6	-52120	gtex_brain_putamen_basal
rs6087641	20	33467717	NCOA6	ENSG00000198646.9	1.126E-6	-54265	gtex_brain_putamen_basal
rs6087642	20	33468306	NCOA6	ENSG00000198646.9	4.986E-6	-54854	gtex_brain_putamen_basal
rs1013677	20	33468793	NCOA6	ENSG00000198646.9	1.124E-6	-55341	gtex_brain_putamen_basal
rs6088636	20	33469746	NCOA6	ENSG00000198646.9	1.124E-6	-56294	gtex_brain_putamen_basal
rs4911163	20	33470694	NCOA6	ENSG00000198646.9	1.124E-6	-57242	gtex_brain_putamen_basal
rs6088640	20	33472509	NCOA6	ENSG00000198646.9	1.124E-6	-59057	gtex_brain_putamen_basal
rs6087643	20	33474462	NCOA6	ENSG00000198646.9	1.124E-6	-61010	gtex_brain_putamen_basal
rs1060615	20	33478381	NCOA6	ENSG00000198646.9	1.124E-6	-64929	gtex_brain_putamen_basal
rs4911447	20	33479445	NCOA6	ENSG00000198646.9	1.124E-6	-65993	gtex_brain_putamen_basal
rs6088642	20	33483186	NCOA6	ENSG00000198646.9	1.124E-6	-69734	gtex_brain_putamen_basal
rs6119542	20	33484545	NCOA6	ENSG00000198646.9	1.232E-6	-71093	gtex_brain_putamen_basal
rs6119543	20	33484757	NCOA6	ENSG00000198646.9	4.093E-7	-71305	gtex_brain_putamen_basal
rs8123210	20	33486047	NCOA6	ENSG00000198646.9	2.983E-6	-72595	gtex_brain_putamen_basal
rs6087646	20	33486048	NCOA6	ENSG00000198646.9	4.452E-7	-72596	gtex_brain_putamen_basal
rs6120756	20	33486596	NCOA6	ENSG00000198646.9	1.124E-6	-73144	gtex_brain_putamen_basal
rs2207147	20	33488013	NCOA6	ENSG00000198646.9	1.124E-6	-74561	gtex_brain_putamen_basal
rs6120757	20	33488771	NCOA6	ENSG00000198646.9	4.482E-6	-75319	gtex_brain_putamen_basal
rs397864422	20	33489906	NCOA6	ENSG00000198646.9	1.259E-7	-76454	gtex_brain_putamen_basal
rs926734	20	33491700	NCOA6	ENSG00000198646.9	6.553E-7	-78248	gtex_brain_putamen_basal
rs6120758	20	33492523	NCOA6	ENSG00000198646.9	1.124E-6	-79071	gtex_brain_putamen_basal
rs7266550	20	33495510	NCOA6	ENSG00000198646.9	1.124E-6	-82058	gtex_brain_putamen_basal
rs2378293	20	33499052	NCOA6	ENSG00000198646.9	1.668E-6	-85600	gtex_brain_putamen_basal
rs3787214	20	33500245	NCOA6	ENSG00000198646.9	1.124E-6	-86793	gtex_brain_putamen_basal
rs2378294	20	33500378	NCOA6	ENSG00000198646.9	1.124E-6	-86926	gtex_brain_putamen_basal
rs6088646	20	33505937	NCOA6	ENSG00000198646.9	1.124E-6	-92485	gtex_brain_putamen_basal
rs6120763	20	33506400	NCOA6	ENSG00000198646.9	1.124E-6	-92948	gtex_brain_putamen_basal
rs2076667	20	33506964	NCOA6	ENSG00000198646.9	1.124E-6	-93512	gtex_brain_putamen_basal
rs3746450	20	33508588	NCOA6	ENSG00000198646.9	1.124E-6	-95136	gtex_brain_putamen_basal
rs3818273	20	33509275	NCOA6	ENSG00000198646.9	1.124E-6	-95823	gtex_brain_putamen_basal
rs6087649	20	33510662	NCOA6	ENSG00000198646.9	1.124E-6	-97210	gtex_brain_putamen_basal
rs4911449	20	33512236	NCOA6	ENSG00000198646.9	1.124E-6	-98784	gtex_brain_putamen_basal
rs4911451	20	33512466	NCOA6	ENSG00000198646.9	1.124E-6	-99014	gtex_brain_putamen_basal
rs6088650	20	33514465	NCOA6	ENSG00000198646.9	1.124E-6	-101013	gtex_brain_putamen_basal
rs725521	20	33516071	NCOA6	ENSG00000198646.9	1.124E-6	-102619	gtex_brain_putamen_basal
rs6087651	20	33518353	NCOA6	ENSG00000198646.9	1.124E-6	-104901	gtex_brain_putamen_basal
rs6088653	20	33520321	NCOA6	ENSG00000198646.9	1.124E-6	-106869	gtex_brain_putamen_basal
rs6087652	20	33520802	NCOA6	ENSG00000198646.9	5.012E-6	-107350	gtex_brain_putamen_basal
rs6087653	20	33522054	NCOA6	ENSG00000198646.9	1.124E-6	-108602	gtex_brain_putamen_basal
rs6087654	20	33522142	NCOA6	ENSG00000198646.9	1.124E-6	-108690	gtex_brain_putamen_basal
rs6119545	20	33522869	NCOA6	ENSG00000198646.9	1.124E-6	-109417	gtex_brain_putamen_basal
rs4911452	20	33526983	NCOA6	ENSG00000198646.9	5.453E-6	-113531	gtex_brain_putamen_basal
rs6088655	20	33527838	NCOA6	ENSG00000198646.9	1.151E-6	-114386	gtex_brain_putamen_basal
rs3761143	20	33545745	NCOA6	ENSG00000198646.9	5.768E-6	-132293	gtex_brain_putamen_basal
rs6088664	20	33551100	NCOA6	ENSG00000198646.9	5.746E-6	-137648	gtex_brain_putamen_basal
rs3761141	20	33737824	NCOA6	ENSG00000198646.9	6.148E-6	-324372	gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ZFYVE20	0.96	0.96
TGFBRAP1	0.95	0.96
FOXK2	0.95	0.95
DIP2C	0.94	0.95
USP22	0.94	0.94
CLIP2	0.93	0.94
RAPGEF1	0.93	0.94
SEC16A	0.93	0.94
PRDM15	0.93	0.94
SLC35E1	0.93	0.94

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.71	-0.78
MT-CO2	-0.69	-0.77
AF347015.21	-0.68	-0.84
AF347015.27	-0.68	-0.74
FXYD1	-0.68	-0.73
HIGD1B	-0.67	-0.75
AF347015.33	-0.66	-0.70
C1orf54	-0.66	-0.83
AF347015.8	-0.66	-0.75
MT-CYB	-0.65	-0.72

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003682	chromatin binding	ISS		-
GO:0005515	protein binding	IPI		11443112
GO:0030331	estrogen receptor binding	TAS		11443112
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	IPI		11443112
GO:0046965	retinoid X receptor binding	TAS		11443112
GO:0046966	thyroid hormone receptor binding	IDA		11443112
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007420	brain development	ISS	Brain (GO term level: 7)	-
GO:0001701	in utero embryonic development	ISS		-
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0006367	transcription initiation from RNA polymerase II promoter	ISS		-
GO:0030520	estrogen receptor signaling pathway	NAS		11443112
GO:0030099	myeloid cell differentiation	IDA		11302752
GO:0006350	transcription	IEA		-
GO:0006310	DNA recombination	NAS		11443112
GO:0006281	DNA repair	NAS		11443112
GO:0006260	DNA replication	NAS		11443112
GO:0009725	response to hormone stimulus	TAS		11443112
GO:0007507	heart development	ISS		-
GO:0042921	glucocorticoid receptor signaling pathway	NAS		11443112
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA		11443112
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IDA		11443112
GO:0005634	nucleus	NAS		10567404
GO:0005667	transcription factor complex	TAS		11443112
GO:0005730	nucleolus	IDA		18029348

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	Affinity Capture-Western Two-hybrid	BioGRID	14645241
ASCC1	ASC1p50 \| CGI-18 \| RP11-150D20.4	activating signal cointegrator 1 complex subunit 1	Reconstituted Complex	BioGRID	10567404
ASCL2	ASH2 \| HASH2 \| MASH2 \| bHLHa45	achaete-scute complex homolog 2 (Drosophila)	Affinity Capture-MS Affinity Capture-Western Co-purification	BioGRID	12482968
ATF2	CRE-BP1 \| CREB2 \| HB16 \| MGC111558 \| TREB7	activating transcription factor 2	Affinity Capture-Western Co-localization Reconstituted Complex Two-hybrid	BioGRID	14734562
BCL3	BCL4 \| D19S37	B-cell CLL/lymphoma 3	Reconstituted Complex	BioGRID	10497212
CD40	Bp50 \| CDW40 \| MGC9013 \| TNFRSF5 \| p50	CD40 molecule, TNF receptor superfamily member 5	Reconstituted Complex	BioGRID	10847592
CEBPA	C/EBP-alpha \| CEBP	CCAAT/enhancer binding protein (C/EBP), alpha	ASC-2 interacts with C/EBP alpha.	BIND	11302752
CEBPA	C/EBP-alpha \| CEBP	CCAAT/enhancer binding protein (C/EBP), alpha	Affinity Capture-Western Co-localization Two-hybrid	BioGRID	11302752 \|14734562
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	Reconstituted Complex Two-hybrid	BioGRID	10567404 \|11158331
CXADR	CAR \| HCAR	coxsackie virus and adenovirus receptor	Reconstituted Complex	BioGRID	15764585
E2F1	E2F-1 \| RBAP1 \| RBBP3 \| RBP3	E2F transcription factor 1	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	14638867
EP300	KAT3B \| p300	E1A binding protein p300	-	HPRD,BioGRID	10823961
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	Reconstituted Complex Two-hybrid	BioGRID	10567404 \|11158331 \|11773444
ESR2	ER-BETA \| ESR-BETA \| ESRB \| ESTRB \| Erb \| NR3A2	estrogen receptor 2 (ER beta)	-	HPRD,BioGRID	11773444
FGR	FLJ43153 \| MGC75096 \| SRC2 \| c-fgr \| c-src2 \| p55c-fgr \| p58c-fgr	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	Affinity Capture-Western	BioGRID	12482968
FOS	AP-1 \| C-FOS	v-fos FBJ murine osteosarcoma viral oncogene homolog	Reconstituted Complex	BioGRID	10847592
GTF2A1	MGC129969 \| MGC129970 \| TF2A1 \| TFIIA	general transcription factor IIA, 1, 19/37kDa	Reconstituted Complex	BioGRID	10567404
HBXIP	MGC71071 \| XIP	hepatitis B virus x interacting protein	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	14578865
HIST2H3C	H3 \| H3.2 \| H3/M \| H3F2 \| H3FM \| MGC9629	histone cluster 2, H3c	Affinity Capture-Western Reconstituted Complex	BioGRID	12482968
HSAJ2425	p65	p65 protein	Reconstituted Complex	BioGRID	10847592
HSF1	HSTF1	heat shock transcription factor 1	Affinity Capture-Western Co-localization	BioGRID	14960326
HSF1	HSTF1	heat shock transcription factor 1	ASC-2 interacts with HSF1.	BIND	14960326
JUN	AP-1 \| AP1 \| c-Jun	jun oncogene	Reconstituted Complex	BioGRID	10847592
MED23	CRSP130 \| CRSP133 \| CRSP3 \| DKFZp434H0117 \| DRIP130 \| SUR2	mediator complex subunit 23	-	HPRD,BioGRID	10823961
MLL3	DKFZp686C08112 \| FLJ12625 \| FLJ38309 \| HALR \| KIAA1506 \| KMT2C \| MGC119851 \| MGC119852 \| MGC119853	myeloid/lymphoid or mixed-lineage leukemia 3	Affinity Capture-MS Affinity Capture-Western Co-purification	BioGRID	12482968
NFKB1	DKFZp686C01211 \| EBP-1 \| KBF1 \| MGC54151 \| NF-kappa-B \| NFKB-p105 \| NFKB-p50 \| p105	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Reconstituted Complex	BioGRID	10847592
NR1H2	LXR-b \| LXRB \| NER \| NER-I \| RIP15 \| UNR	nuclear receptor subfamily 1, group H, member 2	Reconstituted Complex Two-hybrid	BioGRID	11158331 \|15764585
NR3C1	GCCR \| GCR \| GR \| GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	-	HPRD,BioGRID	10567404
NUMA1	NUMA	nuclear mitotic apparatus protein 1	-	HPRD,BioGRID	12519782
PARP1	ADPRT \| ADPRT1 \| PARP \| PARP-1 \| PPOL \| pADPRT-1	poly (ADP-ribose) polymerase 1	Affinity Capture-MS	BioGRID	12519782
PPARA	MGC2237 \| MGC2452 \| NR1C1 \| PPAR \| hPPAR	peroxisome proliferator-activated receptor alpha	Two-hybrid	BioGRID	11158331
PPARG	NR1C3 \| PPARG1 \| PPARG2 \| PPARgamma	peroxisome proliferator-activated receptor gamma	-	HPRD	10788465
PPARG	NR1C3 \| PPARG1 \| PPARG2 \| PPARgamma	peroxisome proliferator-activated receptor gamma	Two-hybrid	BioGRID	11158331
PRKDC	DNA-PKcs \| DNAPK \| DNPK1 \| HYRC \| HYRC1 \| XRCC7 \| p350	protein kinase, DNA-activated, catalytic polypeptide	Affinity Capture-MS Biochemical Activity	BioGRID	10823961
PRMT2	HRMT1L1 \| MGC111373	protein arginine methyltransferase 2	PRMT2 interacts with PRIP.	BIND	12039952
RARA	NR1B1 \| RAR	retinoic acid receptor, alpha	-	HPRD,BioGRID	10567404
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	Rb interacts with ASC-2.	BIND	14645241
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	14645241
RBBP5	RBQ3 \| SWD1	retinoblastoma binding protein 5	Affinity Capture-MS Affinity Capture-Western Co-purification	BioGRID	12482968
RBM14	COAA \| DKFZp779J0927 \| MGC15912 \| MGC31756 \| PSP2 \| SIP \| SYTIP1 \| TMEM137	RNA binding motif protein 14	-	HPRD	11443112
RBM39	CAPER \| CAPERalpha \| CC1.3 \| DKFZp781C0423 \| FLJ44170 \| HCC1 \| RNPC2 \| fSAP59	RNA binding motif protein 39	-	HPRD	11704680
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Reconstituted Complex	BioGRID	10847592
RXRA	FLJ00280 \| FLJ00318 \| FLJ16020 \| FLJ16733 \| MGC102720 \| NR2B1	retinoid X receptor, alpha	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10567404 \|11158331 \|11773444 \|14578865
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10567404 \|10847592 \|11158331 \|12482968
SRF	MCM1	serum response factor (c-fos serum response element-binding transcription factor)	Reconstituted Complex	BioGRID	10847592
TBP	GTF2D \| GTF2D1 \| MGC117320 \| MGC126054 \| MGC126055 \| SCA17 \| TFIID	TATA box binding protein	Reconstituted Complex	BioGRID	10567404
TGS1	DKFZp762A163 \| FLJ22995 \| NCOA6IP \| PIMT \| PIPMT	trimethylguanosine synthase homolog (S. cerevisiae)	-	HPRD,BioGRID	11517327
THRA	AR7 \| EAR7 \| ERB-T-1 \| ERBA \| ERBA1 \| MGC000261 \| MGC43240 \| NR1A1 \| THRA1 \| THRA2 \| c-ERBA-1	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10567404 \|10847592 \|11158331
THRB	ERBA-BETA \| ERBA2 \| GRTH \| MGC126109 \| MGC126110 \| NR1A2 \| PRTH \| THR1 \| THRB1 \| THRB2	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	Reconstituted Complex Two-hybrid	BioGRID	10567404 \|10823961 \|11158331 \|11773444
TUBA4A	FLJ30169 \| H2-ALPHA \| TUBA1	tubulin, alpha 4a	Affinity Capture-MS Co-purification	BioGRID	12482968
TUBB	M40 \| MGC117247 \| MGC16435 \| OK/SW-cl.56 \| TUBB1 \| TUBB5	tubulin, beta	Affinity Capture-MS Co-purification	BioGRID	12482968
XRCC5	FLJ39089 \| KARP-1 \| KARP1 \| KU80 \| KUB2 \| Ku86 \| NFIV	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	Affinity Capture-MS	BioGRID	10823961 \|12519782
XRCC6	CTC75 \| CTCBF \| G22P1 \| KU70 \| ML8 \| TLAA	X-ray repair complementing defective repair in Chinese hamster cells 6	Affinity Capture-MS Reconstituted Complex	BioGRID	10823961 \|12519782
ZNF335	NIF1 \| NIF2	zinc finger protein 335	-	HPRD,BioGRID	12215545

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PID AR PATHWAY	61	46	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	36	27	All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION	104	72	All SZGR 2.0 genes in this pathway
REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	24	17	All SZGR 2.0 genes in this pathway
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	24	16	All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	23	16	All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY	352	181	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS	478	302	All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	168	115	All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN CLOCK	53	40	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	72	53	All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN	309	191	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP	329	196	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS UP	127	79	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX4 UP	11	8	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP	424	268	All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES	147	87	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 20Q11 AMPLICON	31	18	All SZGR 2.0 genes in this pathway
NIKOLSKY MUTATED AND AMPLIFIED IN BREAST CANCER	94	60	All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER DN	76	57	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL SHORT TERM	32	15	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN	271	175	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP	863	514	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED	351	238	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE	317	190	All SZGR 2.0 genes in this pathway
IKEDA MIR133 TARGETS UP	43	27	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-10	293	299	m8	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	293	299	m8	hsa-miR-10b	UACCCUGUAGAACCGAAUUUGU
miR-224	66	72	m8	hsa-miR-224	CAAGUCACUAGUGGUUCCGUUUA
miR-23	482	489	1A,m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	482	489	1A,m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-323	482	488	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-369-3p	410	416	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	410	416	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-377	347	354	1A,m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-410	412	418	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-486	291	297	m8	hsa-miR-486	UCCUGUACUGAGCUGCCCCGAG
miR-493-5p	477	483	1A	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: NCOA6