Gene Page: CUL9

Summary ?
GeneID23113
SymbolCUL9
SynonymsH7AP1|PARC
Descriptioncullin 9
ReferenceMIM:607489|HGNC:HGNC:15982|Ensembl:ENSG00000112659|HPRD:06317|Vega:OTTHUMG00000014723
Gene typeprotein-coding
Map location6p21.1
Pascal p-value3.244E-5
Sherlock p-value0.609
Fetal beta-0.577
eGeneCaudate basal ganglia
Cortex
SupportCompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MGA0.970.97
BIRC60.970.97
C10orf180.960.96
NSD10.960.95
UBR50.960.96
TUG10.950.96
MED10.950.96
SBF20.950.95
ZNF4450.950.94
CLASP10.950.95
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.71-0.83
MT-CO2-0.70-0.84
IFI27-0.70-0.83
FXYD1-0.70-0.81
C5orf53-0.69-0.72
HIGD1B-0.68-0.84
AF347015.27-0.68-0.79
S100B-0.68-0.77
AF347015.33-0.67-0.78
HLA-F-0.67-0.70

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI18230339 
GO:0005524ATP bindingIEA-
GO:0008270zinc ion bindingIEA-
GO:0031625ubiquitin protein ligase bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0030071regulation of mitotic metaphase/anaphase transitionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005680anaphase-promoting complexIEA-
GO:0005737cytoplasmIEA-
GO:0031461cullin-RING ubiquitin ligase complexIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN 17582All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335193All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
SCHWAB TARGETS OF BMYB POLYMORPHIC VARIANTS DN 1712All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314188All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
STAMBOLSKY TARGETS OF MUTATED TP53 DN 5024All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 3 UP 17097All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 6 UP 14081All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 7 UP 11868All SZGR 2.0 genes in this pathway