Gene Page: ACKR1
Summary ?
| GeneID | 2532 |
| Symbol | ACKR1 |
| Synonyms | CCBP1|CD234|DARC|Dfy|FY|GPD|GpFy|WBCQ1 |
| Description | atypical chemokine receptor 1 (Duffy blood group) |
| Reference | MIM:613665|HGNC:HGNC:4035|Ensembl:ENSG00000213088|HPRD:00192|Vega:OTTHUMG00000037182 |
| Gene type | protein-coding |
| Map location | 1q21-q22 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs17389107 | chr2 | 18498020 | DARC | 2532 | 0.02 | trans | ||
| rs711251 | chr2 | 36706420 | DARC | 2532 | 0.15 | trans | ||
| rs16829545 | chr2 | 151977407 | DARC | 2532 | 2.484E-6 | trans | ||
| rs16841750 | chr2 | 158288461 | DARC | 2532 | 0.01 | trans | ||
| rs7584986 | chr2 | 184111432 | DARC | 2532 | 0.02 | trans | ||
| rs16955618 | chr15 | 29937543 | DARC | 2532 | 1.303E-11 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C19orf6 | 0.85 | 0.86 |
| SYVN1 | 0.85 | 0.86 |
| ZNF335 | 0.85 | 0.83 |
| ATG2A | 0.85 | 0.86 |
| SMG5 | 0.85 | 0.84 |
| FAM160B2 | 0.84 | 0.85 |
| CLCN7 | 0.84 | 0.84 |
| KRBA1 | 0.84 | 0.84 |
| CABIN1 | 0.83 | 0.84 |
| PIGQ | 0.83 | 0.82 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.64 | -0.65 |
| GNG11 | -0.59 | -0.61 |
| AF347015.31 | -0.58 | -0.56 |
| C1orf54 | -0.57 | -0.60 |
| MT-CO2 | -0.57 | -0.56 |
| SYCP3 | -0.56 | -0.58 |
| AL050337.1 | -0.54 | -0.58 |
| AF347015.27 | -0.53 | -0.52 |
| AF347015.8 | -0.53 | -0.52 |
| CLEC2B | -0.52 | -0.60 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004872 | receptor activity | IEA | - | |
| GO:0004950 | chemokine receptor activity | NAS | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007186 | G-protein coupled receptor protein signaling pathway | IEA | - | |
| GO:0007165 | signal transduction | IEA | - | |
| GO:0006954 | inflammatory response | IEA | - | |
| GO:0006952 | defense response | NAS | 10570183 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0016021 | integral to membrane | IEA | - | |
| GO:0005886 | plasma membrane | TAS | 7689250 |