Gene Page: DGCR9
Summary ?
| GeneID | 25787 |
| Symbol | DGCR9 |
| Synonyms | DGS-A |
| Description | DiGeorge syndrome critical region gene 9 (non-protein coding) |
| Reference | HGNC:HGNC:17227|Ensembl:ENSG00000273032| |
| Gene type | ncRNA |
| Map location | 22q11.21 |
| Pascal p-value | 0.01 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Frontal Cortex BA9 Nucleus accumbens basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs183735345 | 22 | 18930729 | DGCR9 | ENSG00000273032.1 | 1.22946E-7 | 0.01 | -74618 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PVRL1 | 0.87 | 0.85 |
| CACNA1I | 0.87 | 0.90 |
| PITPNM2 | 0.86 | 0.86 |
| UNC13A | 0.86 | 0.86 |
| SPTBN4 | 0.86 | 0.86 |
| RIMBP2 | 0.86 | 0.86 |
| RHOBTB2 | 0.85 | 0.84 |
| KIAA0284 | 0.85 | 0.85 |
| GARNL4 | 0.85 | 0.84 |
| SGSM1 | 0.84 | 0.84 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PECI | -0.48 | -0.50 |
| GNG11 | -0.48 | -0.47 |
| MYL12A | -0.48 | -0.53 |
| ACAA2 | -0.46 | -0.45 |
| C1orf54 | -0.46 | -0.43 |
| AF347015.21 | -0.45 | -0.32 |
| C1orf61 | -0.45 | -0.47 |
| IMPA2 | -0.44 | -0.48 |
| RPS7 | -0.44 | -0.38 |
| RPS27L | -0.43 | -0.42 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| SHEN SMARCA2 TARGETS DN | 357 | 212 | All SZGR 2.0 genes in this pathway |
| FRASOR RESPONSE TO SERM OR FULVESTRANT UP | 24 | 14 | All SZGR 2.0 genes in this pathway |