Gene Page: FSCN2
Summary ?
| GeneID | 25794 |
| Symbol | FSCN2 |
| Synonyms | RFSN|RP30 |
| Description | fascin actin-bundling protein 2, retinal |
| Reference | MIM:607643|HGNC:HGNC:3960|Ensembl:ENSG00000186765|HPRD:06366|Vega:OTTHUMG00000167477 |
| Gene type | protein-coding |
| Map location | 17q25 |
| Pascal p-value | 0.004 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PDE4D | 0.90 | 0.92 |
| AP1G1 | 0.88 | 0.92 |
| SLC38A1 | 0.88 | 0.93 |
| LASS6 | 0.88 | 0.92 |
| ATP8A2 | 0.88 | 0.92 |
| MARCH6 | 0.88 | 0.92 |
| GPD1L | 0.88 | 0.91 |
| KLHL15 | 0.87 | 0.90 |
| NNT | 0.87 | 0.91 |
| AVL9 | 0.87 | 0.92 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FXYD1 | -0.70 | -0.80 |
| HSD17B14 | -0.69 | -0.76 |
| HIGD1B | -0.68 | -0.80 |
| AF347015.31 | -0.68 | -0.76 |
| SERPINB6 | -0.68 | -0.72 |
| MT-CO2 | -0.67 | -0.77 |
| TLCD1 | -0.66 | -0.77 |
| HEPN1 | -0.66 | -0.71 |
| TSC22D4 | -0.66 | -0.73 |
| SLC25A18 | -0.66 | -0.74 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | 35 | 25 | All SZGR 2.0 genes in this pathway |
| BORCZUK MALIGNANT MESOTHELIOMA DN | 104 | 59 | All SZGR 2.0 genes in this pathway |
| BOGNI TREATMENT RELATED MYELOID LEUKEMIA DN | 33 | 19 | All SZGR 2.0 genes in this pathway |
| LINDGREN BLADDER CANCER CLUSTER 3 DN | 229 | 142 | All SZGR 2.0 genes in this pathway |
| JAZAG TGFB1 SIGNALING UP | 108 | 69 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON | 335 | 181 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 14HR DN | 298 | 200 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN IPS HCP WITH H3 UNMETHYLATED | 80 | 50 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES HCP WITH H3 UNMETHYLATED | 63 | 31 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3 UNMETHYLATED | 228 | 119 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 1HR UP | 61 | 44 | All SZGR 2.0 genes in this pathway |