Gene Page: CNOT10
Summary ?
| GeneID | 25904 |
| Symbol | CNOT10 |
| Synonyms | - |
| Description | CCR4-NOT transcription complex subunit 10 |
| Reference | HGNC:HGNC:23817|Ensembl:ENSG00000182973|HPRD:16731|Vega:OTTHUMG00000130748 |
| Gene type | protein-coding |
| Map location | 3p22.3 |
| Pascal p-value | 0.015 |
| Sherlock p-value | 0.264 |
| Fetal beta | 0.68 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.006 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16894557 | chr6 | 28999825 | CNOT10 | 25904 | 0.08 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| LRRC47 | 0.94 | 0.93 |
| MKRN1 | 0.94 | 0.94 |
| VCP | 0.94 | 0.94 |
| PSMD3 | 0.94 | 0.93 |
| SF3B2 | 0.93 | 0.93 |
| KIAA1967 | 0.93 | 0.93 |
| EFTUD2 | 0.93 | 0.93 |
| RAB35 | 0.93 | 0.93 |
| LRRC59 | 0.93 | 0.93 |
| PES1 | 0.93 | 0.94 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.84 | -0.88 |
| MT-CO2 | -0.83 | -0.87 |
| AF347015.33 | -0.82 | -0.87 |
| AF347015.27 | -0.81 | -0.87 |
| AF347015.8 | -0.80 | -0.86 |
| MT-CYB | -0.80 | -0.85 |
| AF347015.21 | -0.79 | -0.89 |
| FXYD1 | -0.79 | -0.85 |
| HIGD1B | -0.78 | -0.84 |
| AF347015.2 | -0.77 | -0.84 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005488 | binding | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG RNA DEGRADATION | 59 | 37 | All SZGR 2.0 genes in this pathway |
| REACTOME DEADENYLATION OF MRNA | 22 | 14 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF MRNA | 284 | 128 | All SZGR 2.0 genes in this pathway |
| REACTOME DEADENYLATION DEPENDENT MRNA DECAY | 48 | 29 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF RNA | 330 | 155 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| BENPORATH CYCLING GENES | 648 | 385 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS DN | 442 | 275 | All SZGR 2.0 genes in this pathway |
| WHITFIELD CELL CYCLE G2 M | 216 | 124 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |
| RAO BOUND BY SALL4 ISOFORM B | 517 | 302 | All SZGR 2.0 genes in this pathway |