Gene Page: INTS1
Summary ?
| GeneID | 26173 |
| Symbol | INTS1 |
| Synonyms | INT1|NET28 |
| Description | integrator complex subunit 1 |
| Reference | MIM:611345|HGNC:HGNC:24555|Ensembl:ENSG00000164880|Vega:OTTHUMG00000151449 |
| Gene type | protein-coding |
| Map location | 7p22.3 |
| Pascal p-value | 0.534 |
| Fetal beta | -0.426 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
| Support | CompositeSet Darnell FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| DNM:Gulsuner_2013 | Whole Exome Sequencing analysis | 155 DNMs identified by exome sequencing of quads or trios of schizophrenia individuals and their parents. |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| INTS1 | chr7 | 1538957 | C | T | NM_001080453 | p.295S>N | missense | Schizophrenia | DNM:Gulsuner_2013 |
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg24816916 | 7 | 1534200 | INTS1 | 3.82E-5 | 0.622 | 0.02 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7796482 | 7 | 1496880 | INTS1 | ENSG00000164880.11 | 6.108E-7 | 0.01 | 48609 | gtex_brain_ba24 |
| rs59536285 | 7 | 1497430 | INTS1 | ENSG00000164880.11 | 9.364E-7 | 0.01 | 48059 | gtex_brain_ba24 |
| rs4406316 | 7 | 1499339 | INTS1 | ENSG00000164880.11 | 2.29E-7 | 0.01 | 46150 | gtex_brain_ba24 |
| rs7459289 | 7 | 1499599 | INTS1 | ENSG00000164880.11 | 1.086E-6 | 0.01 | 45890 | gtex_brain_ba24 |
| rs4725103 | 7 | 1501108 | INTS1 | ENSG00000164880.11 | 1.169E-6 | 0.01 | 44381 | gtex_brain_ba24 |
| rs4554363 | 7 | 1505436 | INTS1 | ENSG00000164880.11 | 1.614E-7 | 0.01 | 40053 | gtex_brain_ba24 |
| rs6951839 | 7 | 1506977 | INTS1 | ENSG00000164880.11 | 7.839E-7 | 0.01 | 38512 | gtex_brain_ba24 |
| rs6962610 | 7 | 1507011 | INTS1 | ENSG00000164880.11 | 7.162E-7 | 0.01 | 38478 | gtex_brain_ba24 |
| rs11972070 | 7 | 1508191 | INTS1 | ENSG00000164880.11 | 2.154E-7 | 0.01 | 37298 | gtex_brain_ba24 |
| rs11309531 | 7 | 1509049 | INTS1 | ENSG00000164880.11 | 2.094E-7 | 0.01 | 36440 | gtex_brain_ba24 |
| rs28615604 | 7 | 1509707 | INTS1 | ENSG00000164880.11 | 1.222E-7 | 0.01 | 35782 | gtex_brain_ba24 |
| rs57790608 | 7 | 1511504 | INTS1 | ENSG00000164880.11 | 1.403E-7 | 0.01 | 33985 | gtex_brain_ba24 |
| rs62435331 | 7 | 1511589 | INTS1 | ENSG00000164880.11 | 1.402E-7 | 0.01 | 33900 | gtex_brain_ba24 |
| rs10265526 | 7 | 1517700 | INTS1 | ENSG00000164880.11 | 1.33E-6 | 0.01 | 27789 | gtex_brain_ba24 |
| rs10265535 | 7 | 1517718 | INTS1 | ENSG00000164880.11 | 1.105E-7 | 0.01 | 27771 | gtex_brain_ba24 |
| rs11977356 | 7 | 1518336 | INTS1 | ENSG00000164880.11 | 9.725E-8 | 0.01 | 27153 | gtex_brain_ba24 |
| rs9692169 | 7 | 1518869 | INTS1 | ENSG00000164880.11 | 1.098E-7 | 0.01 | 26620 | gtex_brain_ba24 |
| rs56975547 | 7 | 1519011 | INTS1 | ENSG00000164880.11 | 1.108E-6 | 0.01 | 26478 | gtex_brain_ba24 |
| rs9692164 | 7 | 1519361 | INTS1 | ENSG00000164880.11 | 1.099E-7 | 0.01 | 26128 | gtex_brain_ba24 |
| rs4546558 | 7 | 1519892 | INTS1 | ENSG00000164880.11 | 1.102E-7 | 0.01 | 25597 | gtex_brain_ba24 |
| rs7783971 | 7 | 1519946 | INTS1 | ENSG00000164880.11 | 1.101E-7 | 0.01 | 25543 | gtex_brain_ba24 |
| rs4560715 | 7 | 1521875 | INTS1 | ENSG00000164880.11 | 1.11E-7 | 0.01 | 23614 | gtex_brain_ba24 |
| rs10227674 | 7 | 1522157 | INTS1 | ENSG00000164880.11 | 1.109E-7 | 0.01 | 23332 | gtex_brain_ba24 |
| rs11971663 | 7 | 1522607 | INTS1 | ENSG00000164880.11 | 1.113E-7 | 0.01 | 22882 | gtex_brain_ba24 |
| rs10807961 | 7 | 1522849 | INTS1 | ENSG00000164880.11 | 1.492E-7 | 0.01 | 22640 | gtex_brain_ba24 |
| rs10952126 | 7 | 1522884 | INTS1 | ENSG00000164880.11 | 1.493E-7 | 0.01 | 22605 | gtex_brain_ba24 |
| rs1137532 | 7 | 1522988 | INTS1 | ENSG00000164880.11 | 1.061E-7 | 0.01 | 22501 | gtex_brain_ba24 |
| rs10235180 | 7 | 1523559 | INTS1 | ENSG00000164880.11 | 7.31E-8 | 0.01 | 21930 | gtex_brain_ba24 |
| rs11972722 | 7 | 1523956 | INTS1 | ENSG00000164880.11 | 1.268E-7 | 0.01 | 21533 | gtex_brain_ba24 |
| rs10280410 | 7 | 1525563 | INTS1 | ENSG00000164880.11 | 1.276E-7 | 0.01 | 19926 | gtex_brain_ba24 |
| rs10277028 | 7 | 1525761 | INTS1 | ENSG00000164880.11 | 1.279E-7 | 0.01 | 19728 | gtex_brain_ba24 |
| rs6946371 | 7 | 1525769 | INTS1 | ENSG00000164880.11 | 8.063E-7 | 0.01 | 19720 | gtex_brain_ba24 |
| rs6969991 | 7 | 1526181 | INTS1 | ENSG00000164880.11 | 1.136E-7 | 0.01 | 19308 | gtex_brain_ba24 |
| rs7785978 | 7 | 1527255 | INTS1 | ENSG00000164880.11 | 5.513E-7 | 0.01 | 18234 | gtex_brain_ba24 |
| rs10279407 | 7 | 1527687 | INTS1 | ENSG00000164880.11 | 1.289E-7 | 0.01 | 17802 | gtex_brain_ba24 |
| rs10267772 | 7 | 1527735 | INTS1 | ENSG00000164880.11 | 1.289E-7 | 0.01 | 17754 | gtex_brain_ba24 |
| rs10230455 | 7 | 1528661 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 16828 | gtex_brain_ba24 |
| rs10230463 | 7 | 1528684 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 16805 | gtex_brain_ba24 |
| rs4425657 | 7 | 1529201 | INTS1 | ENSG00000164880.11 | 4.102E-7 | 0.01 | 16288 | gtex_brain_ba24 |
| rs4380839 | 7 | 1529427 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 16062 | gtex_brain_ba24 |
| rs57907126 | 7 | 1529725 | INTS1 | ENSG00000164880.11 | 1.343E-7 | 0.01 | 15764 | gtex_brain_ba24 |
| rs10234680 | 7 | 1529761 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 15728 | gtex_brain_ba24 |
| rs6968011 | 7 | 1529860 | INTS1 | ENSG00000164880.11 | 1.195E-7 | 0.01 | 15629 | gtex_brain_ba24 |
| rs6463854 | 7 | 1530436 | INTS1 | ENSG00000164880.11 | 1.687E-7 | 0.01 | 15053 | gtex_brain_ba24 |
| rs6463855 | 7 | 1530465 | INTS1 | ENSG00000164880.11 | 1.687E-7 | 0.01 | 15024 | gtex_brain_ba24 |
| rs7812194 | 7 | 1530489 | INTS1 | ENSG00000164880.11 | 1.687E-7 | 0.01 | 15000 | gtex_brain_ba24 |
| rs7812196 | 7 | 1530494 | INTS1 | ENSG00000164880.11 | 1.687E-7 | 0.01 | 14995 | gtex_brain_ba24 |
| rs4339536 | 7 | 1531152 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 14337 | gtex_brain_ba24 |
| rs4436031 | 7 | 1531260 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 14229 | gtex_brain_ba24 |
| rs4436032 | 7 | 1531261 | INTS1 | ENSG00000164880.11 | 8.023E-7 | 0.01 | 14228 | gtex_brain_ba24 |
| rs56318509 | 7 | 1532217 | INTS1 | ENSG00000164880.11 | 8.035E-7 | 0.01 | 13272 | gtex_brain_ba24 |
| rs149857060 | 7 | 1532258 | INTS1 | ENSG00000164880.11 | 5.454E-7 | 0.01 | 13231 | gtex_brain_ba24 |
| rs56315048 | 7 | 1532401 | INTS1 | ENSG00000164880.11 | 1.103E-6 | 0.01 | 13088 | gtex_brain_ba24 |
| rs56279771 | 7 | 1532470 | INTS1 | ENSG00000164880.11 | 4.107E-7 | 0.01 | 13019 | gtex_brain_ba24 |
| rs10247000 | 7 | 1532536 | INTS1 | ENSG00000164880.11 | 8.3E-8 | 0.01 | 12953 | gtex_brain_ba24 |
| rs10229645 | 7 | 1532631 | INTS1 | ENSG00000164880.11 | 9.342E-8 | 0.01 | 12858 | gtex_brain_ba24 |
| rs2251226 | 7 | 1533513 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 11976 | gtex_brain_ba24 |
| rs2251231 | 7 | 1533556 | INTS1 | ENSG00000164880.11 | 1.104E-6 | 0.01 | 11933 | gtex_brain_ba24 |
| rs2251232 | 7 | 1533566 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 11923 | gtex_brain_ba24 |
| rs2251235 | 7 | 1533788 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 11701 | gtex_brain_ba24 |
| rs732492 | 7 | 1533866 | INTS1 | ENSG00000164880.11 | 8.036E-7 | 0.01 | 11623 | gtex_brain_ba24 |
| rs892527 | 7 | 1533964 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 11525 | gtex_brain_ba24 |
| rs732491 | 7 | 1534045 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 11444 | gtex_brain_ba24 |
| rs892528 | 7 | 1534146 | INTS1 | ENSG00000164880.11 | 8.036E-7 | 0.01 | 11343 | gtex_brain_ba24 |
| rs892529 | 7 | 1534155 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 11334 | gtex_brain_ba24 |
| rs752791 | 7 | 1534425 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 11064 | gtex_brain_ba24 |
| rs752792 | 7 | 1534593 | INTS1 | ENSG00000164880.11 | 8.066E-7 | 0.01 | 10896 | gtex_brain_ba24 |
| rs5881898 | 7 | 1534751 | INTS1 | ENSG00000164880.11 | 1.345E-7 | 0.01 | 10738 | gtex_brain_ba24 |
| rs71686331 | 7 | 1534752 | INTS1 | ENSG00000164880.11 | 2.625E-7 | 0.01 | 10737 | gtex_brain_ba24 |
| rs892530 | 7 | 1535051 | INTS1 | ENSG00000164880.11 | 2.971E-7 | 0.01 | 10438 | gtex_brain_ba24 |
| rs6971387 | 7 | 1535632 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 9857 | gtex_brain_ba24 |
| rs6946025 | 7 | 1536436 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 9053 | gtex_brain_ba24 |
| rs6946028 | 7 | 1536448 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 9041 | gtex_brain_ba24 |
| rs6950990 | 7 | 1536566 | INTS1 | ENSG00000164880.11 | 7.299E-7 | 0.01 | 8923 | gtex_brain_ba24 |
| rs6976875 | 7 | 1536630 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 8859 | gtex_brain_ba24 |
| rs3735660 | 7 | 1536717 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 8772 | gtex_brain_ba24 |
| rs3735662 | 7 | 1537075 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 8414 | gtex_brain_ba24 |
| rs7795749 | 7 | 1537230 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 8259 | gtex_brain_ba24 |
| rs7789285 | 7 | 1537413 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 8076 | gtex_brain_ba24 |
| rs7789292 | 7 | 1537417 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 8072 | gtex_brain_ba24 |
| rs7789410 | 7 | 1537439 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 8050 | gtex_brain_ba24 |
| rs57189780 | 7 | 1537686 | INTS1 | ENSG00000164880.11 | 9.755E-8 | 0.01 | 7803 | gtex_brain_ba24 |
| rs7778207 | 7 | 1537704 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 7785 | gtex_brain_ba24 |
| rs57092311 | 7 | 1538539 | INTS1 | ENSG00000164880.11 | 1.331E-7 | 0.01 | 6950 | gtex_brain_ba24 |
| rs2289034 | 7 | 1538595 | INTS1 | ENSG00000164880.11 | 1.15E-7 | 0.01 | 6894 | gtex_brain_ba24 |
| rs2289035 | 7 | 1538614 | INTS1 | ENSG00000164880.11 | 8.045E-7 | 0.01 | 6875 | gtex_brain_ba24 |
| rs750005 | 7 | 1538877 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 6612 | gtex_brain_ba24 |
| rs2304358 | 7 | 1540049 | INTS1 | ENSG00000164880.11 | 1.539E-7 | 0.01 | 5440 | gtex_brain_ba24 |
| rs55738771 | 7 | 1540502 | INTS1 | ENSG00000164880.11 | 1.195E-7 | 0.01 | 4987 | gtex_brain_ba24 |
| rs56173921 | 7 | 1540535 | INTS1 | ENSG00000164880.11 | 1.195E-7 | 0.01 | 4954 | gtex_brain_ba24 |
| rs200520727 | 7 | 1540927 | INTS1 | ENSG00000164880.11 | 4.113E-7 | 0.01 | 4562 | gtex_brain_ba24 |
| rs67910335 | 7 | 1540928 | INTS1 | ENSG00000164880.11 | 1.463E-7 | 0.01 | 4561 | gtex_brain_ba24 |
| rs12537304 | 7 | 1541002 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 4487 | gtex_brain_ba24 |
| rs10256386 | 7 | 1541483 | INTS1 | ENSG00000164880.11 | 1.195E-7 | 0.01 | 4006 | gtex_brain_ba24 |
| rs35347915 | 7 | 1542122 | INTS1 | ENSG00000164880.11 | 1.196E-7 | 0.01 | 3367 | gtex_brain_ba24 |
| rs7806171 | 7 | 1542125 | INTS1 | ENSG00000164880.11 | 1.195E-7 | 0.01 | 3364 | gtex_brain_ba24 |
| rs200153548 | 7 | 1542125 | INTS1 | ENSG00000164880.11 | 1.196E-7 | 0.01 | 3364 | gtex_brain_ba24 |
| rs3752714 | 7 | 1542697 | INTS1 | ENSG00000164880.11 | 1.195E-7 | 0.01 | 2792 | gtex_brain_ba24 |
| rs3752715 | 7 | 1542814 | INTS1 | ENSG00000164880.11 | 1.195E-7 | 0.01 | 2675 | gtex_brain_ba24 |
| rs1369011 | 7 | 1543981 | INTS1 | ENSG00000164880.11 | 1.254E-7 | 0.01 | 1508 | gtex_brain_ba24 |
| rs2278460 | 7 | 1544128 | INTS1 | ENSG00000164880.11 | 1.212E-7 | 0.01 | 1361 | gtex_brain_ba24 |
| rs7799232 | 7 | 1545177 | INTS1 | ENSG00000164880.11 | 1.33E-7 | 0.01 | 312 | gtex_brain_ba24 |
| rs11338201 | 7 | 1545228 | INTS1 | ENSG00000164880.11 | 1.329E-7 | 0.01 | 261 | gtex_brain_ba24 |
| rs745563 | 7 | 1545854 | INTS1 | ENSG00000164880.11 | 1.871E-7 | 0.01 | -365 | gtex_brain_ba24 |
| rs67490389 | 7 | 1547058 | INTS1 | ENSG00000164880.11 | 1.172E-7 | 0.01 | -1569 | gtex_brain_ba24 |
| rs66856989 | 7 | 1547215 | INTS1 | ENSG00000164880.11 | 1.658E-7 | 0.01 | -1726 | gtex_brain_ba24 |
| rs67780721 | 7 | 1547220 | INTS1 | ENSG00000164880.11 | 1.853E-7 | 0.01 | -1731 | gtex_brain_ba24 |
| rs6976713 | 7 | 1547447 | INTS1 | ENSG00000164880.11 | 1.192E-7 | 0.01 | -1958 | gtex_brain_ba24 |
| rs113040799 | 7 | 1547708 | INTS1 | ENSG00000164880.11 | 1.42E-7 | 0.01 | -2219 | gtex_brain_ba24 |
| rs113230596 | 7 | 1547709 | INTS1 | ENSG00000164880.11 | 1.423E-7 | 0.01 | -2220 | gtex_brain_ba24 |
| rs58931379 | 7 | 1548157 | INTS1 | ENSG00000164880.11 | 2.027E-7 | 0.01 | -2668 | gtex_brain_ba24 |
| rs55943955 | 7 | 1548674 | INTS1 | ENSG00000164880.11 | 1.277E-7 | 0.01 | -3185 | gtex_brain_ba24 |
| rs56217612 | 7 | 1548842 | INTS1 | ENSG00000164880.11 | 1.982E-7 | 0.01 | -3353 | gtex_brain_ba24 |
| rs7796482 | 7 | 1496880 | INTS1 | ENSG00000164880.11 | 1.291E-6 | 0.01 | 48609 | gtex_brain_putamen_basal |
| rs59536285 | 7 | 1497430 | INTS1 | ENSG00000164880.11 | 1.604E-6 | 0.01 | 48059 | gtex_brain_putamen_basal |
| rs4406316 | 7 | 1499339 | INTS1 | ENSG00000164880.11 | 6.155E-8 | 0.01 | 46150 | gtex_brain_putamen_basal |
| rs7459289 | 7 | 1499599 | INTS1 | ENSG00000164880.11 | 1.593E-7 | 0.01 | 45890 | gtex_brain_putamen_basal |
| rs4725103 | 7 | 1501108 | INTS1 | ENSG00000164880.11 | 4.424E-7 | 0.01 | 44381 | gtex_brain_putamen_basal |
| rs4554363 | 7 | 1505436 | INTS1 | ENSG00000164880.11 | 1.597E-7 | 0.01 | 40053 | gtex_brain_putamen_basal |
| rs6951839 | 7 | 1506977 | INTS1 | ENSG00000164880.11 | 1.99E-7 | 0.01 | 38512 | gtex_brain_putamen_basal |
| rs6962610 | 7 | 1507011 | INTS1 | ENSG00000164880.11 | 1.987E-7 | 0.01 | 38478 | gtex_brain_putamen_basal |
| rs11972070 | 7 | 1508191 | INTS1 | ENSG00000164880.11 | 3.639E-7 | 0.01 | 37298 | gtex_brain_putamen_basal |
| rs11309531 | 7 | 1509049 | INTS1 | ENSG00000164880.11 | 3.518E-7 | 0.01 | 36440 | gtex_brain_putamen_basal |
| rs28615604 | 7 | 1509707 | INTS1 | ENSG00000164880.11 | 1.737E-7 | 0.01 | 35782 | gtex_brain_putamen_basal |
| rs57790608 | 7 | 1511504 | INTS1 | ENSG00000164880.11 | 1.696E-7 | 0.01 | 33985 | gtex_brain_putamen_basal |
| rs62435331 | 7 | 1511589 | INTS1 | ENSG00000164880.11 | 1.698E-7 | 0.01 | 33900 | gtex_brain_putamen_basal |
| rs10265526 | 7 | 1517700 | INTS1 | ENSG00000164880.11 | 2.334E-7 | 0.01 | 27789 | gtex_brain_putamen_basal |
| rs10265535 | 7 | 1517718 | INTS1 | ENSG00000164880.11 | 3.061E-7 | 0.01 | 27771 | gtex_brain_putamen_basal |
| rs11977356 | 7 | 1518336 | INTS1 | ENSG00000164880.11 | 2.605E-7 | 0.01 | 27153 | gtex_brain_putamen_basal |
| rs9692169 | 7 | 1518869 | INTS1 | ENSG00000164880.11 | 3.559E-7 | 0.01 | 26620 | gtex_brain_putamen_basal |
| rs9692164 | 7 | 1519361 | INTS1 | ENSG00000164880.11 | 3.568E-7 | 0.01 | 26128 | gtex_brain_putamen_basal |
| rs4546558 | 7 | 1519892 | INTS1 | ENSG00000164880.11 | 3.57E-7 | 0.01 | 25597 | gtex_brain_putamen_basal |
| rs7783971 | 7 | 1519946 | INTS1 | ENSG00000164880.11 | 3.568E-7 | 0.01 | 25543 | gtex_brain_putamen_basal |
| rs4560715 | 7 | 1521875 | INTS1 | ENSG00000164880.11 | 3.2E-7 | 0.01 | 23614 | gtex_brain_putamen_basal |
| rs10227674 | 7 | 1522157 | INTS1 | ENSG00000164880.11 | 6.493E-7 | 0.01 | 23332 | gtex_brain_putamen_basal |
| rs11971663 | 7 | 1522607 | INTS1 | ENSG00000164880.11 | 3.125E-7 | 0.01 | 22882 | gtex_brain_putamen_basal |
| rs10807961 | 7 | 1522849 | INTS1 | ENSG00000164880.11 | 1.358E-6 | 0.01 | 22640 | gtex_brain_putamen_basal |
| rs10952126 | 7 | 1522884 | INTS1 | ENSG00000164880.11 | 1.522E-6 | 0.01 | 22605 | gtex_brain_putamen_basal |
| rs1137532 | 7 | 1522988 | INTS1 | ENSG00000164880.11 | 5.63E-7 | 0.01 | 22501 | gtex_brain_putamen_basal |
| rs10235180 | 7 | 1523559 | INTS1 | ENSG00000164880.11 | 2.755E-7 | 0.01 | 21930 | gtex_brain_putamen_basal |
| rs11972722 | 7 | 1523956 | INTS1 | ENSG00000164880.11 | 2.226E-7 | 0.01 | 21533 | gtex_brain_putamen_basal |
| rs10280410 | 7 | 1525563 | INTS1 | ENSG00000164880.11 | 2.274E-7 | 0.01 | 19926 | gtex_brain_putamen_basal |
| rs10277028 | 7 | 1525761 | INTS1 | ENSG00000164880.11 | 2.278E-7 | 0.01 | 19728 | gtex_brain_putamen_basal |
| rs6969991 | 7 | 1526181 | INTS1 | ENSG00000164880.11 | 1.988E-7 | 0.01 | 19308 | gtex_brain_putamen_basal |
| rs10279407 | 7 | 1527687 | INTS1 | ENSG00000164880.11 | 2.316E-7 | 0.01 | 17802 | gtex_brain_putamen_basal |
| rs10267772 | 7 | 1527735 | INTS1 | ENSG00000164880.11 | 2.316E-7 | 0.01 | 17754 | gtex_brain_putamen_basal |
| rs10230455 | 7 | 1528661 | INTS1 | ENSG00000164880.11 | 3.715E-7 | 0.01 | 16828 | gtex_brain_putamen_basal |
| rs10230463 | 7 | 1528684 | INTS1 | ENSG00000164880.11 | 3.711E-7 | 0.01 | 16805 | gtex_brain_putamen_basal |
| rs4380839 | 7 | 1529427 | INTS1 | ENSG00000164880.11 | 3.744E-7 | 0.01 | 16062 | gtex_brain_putamen_basal |
| rs57907126 | 7 | 1529725 | INTS1 | ENSG00000164880.11 | 3.365E-7 | 0.01 | 15764 | gtex_brain_putamen_basal |
| rs10234680 | 7 | 1529761 | INTS1 | ENSG00000164880.11 | 3.748E-7 | 0.01 | 15728 | gtex_brain_putamen_basal |
| rs6968011 | 7 | 1529860 | INTS1 | ENSG00000164880.11 | 3.597E-7 | 0.01 | 15629 | gtex_brain_putamen_basal |
| rs6463854 | 7 | 1530436 | INTS1 | ENSG00000164880.11 | 4.169E-7 | 0.01 | 15053 | gtex_brain_putamen_basal |
| rs6463855 | 7 | 1530465 | INTS1 | ENSG00000164880.11 | 4.169E-7 | 0.01 | 15024 | gtex_brain_putamen_basal |
| rs7812194 | 7 | 1530489 | INTS1 | ENSG00000164880.11 | 4.169E-7 | 0.01 | 15000 | gtex_brain_putamen_basal |
| rs7812196 | 7 | 1530494 | INTS1 | ENSG00000164880.11 | 4.169E-7 | 0.01 | 14995 | gtex_brain_putamen_basal |
| rs4339536 | 7 | 1531152 | INTS1 | ENSG00000164880.11 | 3.748E-7 | 0.01 | 14337 | gtex_brain_putamen_basal |
| rs4436031 | 7 | 1531260 | INTS1 | ENSG00000164880.11 | 3.748E-7 | 0.01 | 14229 | gtex_brain_putamen_basal |
| rs10247000 | 7 | 1532536 | INTS1 | ENSG00000164880.11 | 5.107E-7 | 0.01 | 12953 | gtex_brain_putamen_basal |
| rs10229645 | 7 | 1532631 | INTS1 | ENSG00000164880.11 | 3.305E-7 | 0.01 | 12858 | gtex_brain_putamen_basal |
| rs397946656 | 7 | 1533227 | INTS1 | ENSG00000164880.11 | 5.697E-7 | 0.01 | 12262 | gtex_brain_putamen_basal |
| rs2251226 | 7 | 1533513 | INTS1 | ENSG00000164880.11 | 3.748E-7 | 0.01 | 11976 | gtex_brain_putamen_basal |
| rs2251232 | 7 | 1533566 | INTS1 | ENSG00000164880.11 | 3.748E-7 | 0.01 | 11923 | gtex_brain_putamen_basal |
| rs2251235 | 7 | 1533788 | INTS1 | ENSG00000164880.11 | 3.748E-7 | 0.01 | 11701 | gtex_brain_putamen_basal |
| rs892527 | 7 | 1533964 | INTS1 | ENSG00000164880.11 | 3.473E-7 | 0.01 | 11525 | gtex_brain_putamen_basal |
| rs732491 | 7 | 1534045 | INTS1 | ENSG00000164880.11 | 3.748E-7 | 0.01 | 11444 | gtex_brain_putamen_basal |
| rs892529 | 7 | 1534155 | INTS1 | ENSG00000164880.11 | 3.748E-7 | 0.01 | 11334 | gtex_brain_putamen_basal |
| rs752791 | 7 | 1534425 | INTS1 | ENSG00000164880.11 | 3.748E-7 | 0.01 | 11064 | gtex_brain_putamen_basal |
| rs5881898 | 7 | 1534751 | INTS1 | ENSG00000164880.11 | 3.048E-7 | 0.01 | 10738 | gtex_brain_putamen_basal |
| rs71686331 | 7 | 1534752 | INTS1 | ENSG00000164880.11 | 1.38E-7 | 0.01 | 10737 | gtex_brain_putamen_basal |
| rs6971387 | 7 | 1535632 | INTS1 | ENSG00000164880.11 | 3.748E-7 | 0.01 | 9857 | gtex_brain_putamen_basal |
| rs6946025 | 7 | 1536436 | INTS1 | ENSG00000164880.11 | 3.748E-7 | 0.01 | 9053 | gtex_brain_putamen_basal |
| rs6946028 | 7 | 1536448 | INTS1 | ENSG00000164880.11 | 3.748E-7 | 0.01 | 9041 | gtex_brain_putamen_basal |
| rs6976875 | 7 | 1536630 | INTS1 | ENSG00000164880.11 | 3.748E-7 | 0.01 | 8859 | gtex_brain_putamen_basal |
| rs3735660 | 7 | 1536717 | INTS1 | ENSG00000164880.11 | 3.748E-7 | 0.01 | 8772 | gtex_brain_putamen_basal |
| rs3735662 | 7 | 1537075 | INTS1 | ENSG00000164880.11 | 3.748E-7 | 0.01 | 8414 | gtex_brain_putamen_basal |
| rs7795749 | 7 | 1537230 | INTS1 | ENSG00000164880.11 | 3.73E-7 | 0.01 | 8259 | gtex_brain_putamen_basal |
| rs7789285 | 7 | 1537413 | INTS1 | ENSG00000164880.11 | 3.753E-7 | 0.01 | 8076 | gtex_brain_putamen_basal |
| rs7789292 | 7 | 1537417 | INTS1 | ENSG00000164880.11 | 3.753E-7 | 0.01 | 8072 | gtex_brain_putamen_basal |
| rs7789410 | 7 | 1537439 | INTS1 | ENSG00000164880.11 | 3.753E-7 | 0.01 | 8050 | gtex_brain_putamen_basal |
| rs57189780 | 7 | 1537686 | INTS1 | ENSG00000164880.11 | 4.58E-7 | 0.01 | 7803 | gtex_brain_putamen_basal |
| rs7778207 | 7 | 1537704 | INTS1 | ENSG00000164880.11 | 3.753E-7 | 0.01 | 7785 | gtex_brain_putamen_basal |
| rs57092311 | 7 | 1538539 | INTS1 | ENSG00000164880.11 | 3.747E-7 | 0.01 | 6950 | gtex_brain_putamen_basal |
| rs2289034 | 7 | 1538595 | INTS1 | ENSG00000164880.11 | 4.838E-7 | 0.01 | 6894 | gtex_brain_putamen_basal |
| rs750005 | 7 | 1538877 | INTS1 | ENSG00000164880.11 | 3.748E-7 | 0.01 | 6612 | gtex_brain_putamen_basal |
| rs2304358 | 7 | 1540049 | INTS1 | ENSG00000164880.11 | 4.565E-7 | 0.01 | 5440 | gtex_brain_putamen_basal |
| rs55738771 | 7 | 1540502 | INTS1 | ENSG00000164880.11 | 1.822E-7 | 0.01 | 4987 | gtex_brain_putamen_basal |
| rs56173921 | 7 | 1540535 | INTS1 | ENSG00000164880.11 | 1.822E-7 | 0.01 | 4954 | gtex_brain_putamen_basal |
| rs200520727 | 7 | 1540927 | INTS1 | ENSG00000164880.11 | 2.875E-7 | 0.01 | 4562 | gtex_brain_putamen_basal |
| rs67910335 | 7 | 1540928 | INTS1 | ENSG00000164880.11 | 1.959E-7 | 0.01 | 4561 | gtex_brain_putamen_basal |
| rs12537304 | 7 | 1541002 | INTS1 | ENSG00000164880.11 | 3.748E-7 | 0.01 | 4487 | gtex_brain_putamen_basal |
| rs10256386 | 7 | 1541483 | INTS1 | ENSG00000164880.11 | 1.82E-7 | 0.01 | 4006 | gtex_brain_putamen_basal |
| rs35347915 | 7 | 1542122 | INTS1 | ENSG00000164880.11 | 3.262E-7 | 0.01 | 3367 | gtex_brain_putamen_basal |
| rs7806171 | 7 | 1542125 | INTS1 | ENSG00000164880.11 | 3.597E-7 | 0.01 | 3364 | gtex_brain_putamen_basal |
| rs200153548 | 7 | 1542125 | INTS1 | ENSG00000164880.11 | 3.262E-7 | 0.01 | 3364 | gtex_brain_putamen_basal |
| rs3752714 | 7 | 1542697 | INTS1 | ENSG00000164880.11 | 1.822E-7 | 0.01 | 2792 | gtex_brain_putamen_basal |
| rs3752715 | 7 | 1542814 | INTS1 | ENSG00000164880.11 | 1.822E-7 | 0.01 | 2675 | gtex_brain_putamen_basal |
| rs1369011 | 7 | 1543981 | INTS1 | ENSG00000164880.11 | 6.807E-8 | 0.01 | 1508 | gtex_brain_putamen_basal |
| rs2278460 | 7 | 1544128 | INTS1 | ENSG00000164880.11 | 1.379E-7 | 0.01 | 1361 | gtex_brain_putamen_basal |
| rs10252614 | 7 | 1544417 | INTS1 | ENSG00000164880.11 | 5.181E-7 | 0.01 | 1072 | gtex_brain_putamen_basal |
| rs7799232 | 7 | 1545177 | INTS1 | ENSG00000164880.11 | 1.833E-7 | 0.01 | 312 | gtex_brain_putamen_basal |
| rs11338201 | 7 | 1545228 | INTS1 | ENSG00000164880.11 | 1.844E-7 | 0.01 | 261 | gtex_brain_putamen_basal |
| rs745563 | 7 | 1545854 | INTS1 | ENSG00000164880.11 | 7.551E-7 | 0.01 | -365 | gtex_brain_putamen_basal |
| rs67490389 | 7 | 1547058 | INTS1 | ENSG00000164880.11 | 7.819E-8 | 0.01 | -1569 | gtex_brain_putamen_basal |
| rs66856989 | 7 | 1547215 | INTS1 | ENSG00000164880.11 | 8.601E-7 | 0.01 | -1726 | gtex_brain_putamen_basal |
| rs67780721 | 7 | 1547220 | INTS1 | ENSG00000164880.11 | 6.369E-7 | 0.01 | -1731 | gtex_brain_putamen_basal |
| rs6976713 | 7 | 1547447 | INTS1 | ENSG00000164880.11 | 1.966E-7 | 0.01 | -1958 | gtex_brain_putamen_basal |
| rs113040799 | 7 | 1547708 | INTS1 | ENSG00000164880.11 | 6.12E-7 | 0.01 | -2219 | gtex_brain_putamen_basal |
| rs113230596 | 7 | 1547709 | INTS1 | ENSG00000164880.11 | 6.124E-7 | 0.01 | -2220 | gtex_brain_putamen_basal |
| rs58931379 | 7 | 1548157 | INTS1 | ENSG00000164880.11 | 6.404E-8 | 0.01 | -2668 | gtex_brain_putamen_basal |
| rs55943955 | 7 | 1548674 | INTS1 | ENSG00000164880.11 | 5.709E-7 | 0.01 | -3185 | gtex_brain_putamen_basal |
| rs56217612 | 7 | 1548842 | INTS1 | ENSG00000164880.11 | 5.92E-7 | 0.01 | -3353 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN | 335 | 193 | All SZGR 2.0 genes in this pathway |
| BARRIER CANCER RELAPSE NORMAL SAMPLE DN | 31 | 19 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 7P22 AMPLICON | 38 | 27 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS STEM CELL LONG TERM | 302 | 191 | All SZGR 2.0 genes in this pathway |
| DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN | 287 | 208 | All SZGR 2.0 genes in this pathway |
| SANSOM APC MYC TARGETS | 217 | 138 | All SZGR 2.0 genes in this pathway |
| GRADE COLON CANCER UP | 871 | 505 | All SZGR 2.0 genes in this pathway |
| AGUIRRE PANCREATIC CANCER COPY NUMBER UP | 298 | 174 | All SZGR 2.0 genes in this pathway |
| HOLLEMAN VINCRISTINE RESISTANCE ALL DN | 19 | 11 | All SZGR 2.0 genes in this pathway |