Gene Page: GNMT
Summary ?
| GeneID | 27232 |
| Symbol | GNMT |
| Synonyms | HEL-S-182mP |
| Description | glycine N-methyltransferase |
| Reference | MIM:606628|HGNC:HGNC:4415|Ensembl:ENSG00000124713|HPRD:05970|Vega:OTTHUMG00000014712 |
| Gene type | protein-coding |
| Map location | 6p12 |
| Pascal p-value | 0.774 |
| Fetal beta | -0.277 |
| eGene | Anterior cingulate cortex BA24 Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.033 | |
| GSMA_IIE | Genome scan meta-analysis (European-ancestry samples) | Psr: 0.04433 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs6941212 | chr6 | 42915919 | GNMT | 27232 | 7.043E-5 | cis | ||
| rs2274517 | chr6 | 42932714 | GNMT | 27232 | 4.007E-8 | cis | ||
| rs6941212 | chr6 | 42915919 | GNMT | 27232 | 0.01 | trans | ||
| rs2274517 | chr6 | 42932714 | GNMT | 27232 | 9.283E-6 | trans | ||
| rs3763236 | 6 | 42902508 | GNMT | ENSG00000124713.5 | 1.806E-6 | 0 | -25988 | gtex_brain_ba24 |
| rs9471972 | 6 | 42915021 | GNMT | ENSG00000124713.5 | 2.286E-7 | 0 | -13475 | gtex_brain_ba24 |
| rs7770760 | 6 | 42915403 | GNMT | ENSG00000124713.5 | 9.4E-8 | 0 | -13093 | gtex_brain_ba24 |
| rs6941212 | 6 | 42915920 | GNMT | ENSG00000124713.5 | 1.344E-6 | 0 | -12576 | gtex_brain_ba24 |
| rs4714638 | 6 | 42917017 | GNMT | ENSG00000124713.5 | 1.233E-7 | 0 | -11479 | gtex_brain_ba24 |
| rs9471974 | 6 | 42918984 | GNMT | ENSG00000124713.5 | 9.418E-7 | 0 | -9512 | gtex_brain_ba24 |
| rs9471975 | 6 | 42919222 | GNMT | ENSG00000124713.5 | 1.248E-8 | 0 | -9274 | gtex_brain_ba24 |
| rs2104616 | 6 | 42919969 | GNMT | ENSG00000124713.5 | 2.382E-8 | 0 | -8527 | gtex_brain_ba24 |
| rs59824590 | 6 | 42920416 | GNMT | ENSG00000124713.5 | 1.107E-8 | 0 | -8080 | gtex_brain_ba24 |
| rs9471976 | 6 | 42920549 | GNMT | ENSG00000124713.5 | 3.098E-8 | 0 | -7947 | gtex_brain_ba24 |
| rs4469287 | 6 | 42920844 | GNMT | ENSG00000124713.5 | 3.479E-8 | 0 | -7652 | gtex_brain_ba24 |
| rs28868299 | 6 | 42921221 | GNMT | ENSG00000124713.5 | 1.997E-8 | 0 | -7275 | gtex_brain_ba24 |
| rs145239038 | 6 | 42921474 | GNMT | ENSG00000124713.5 | 5.394E-8 | 0 | -7022 | gtex_brain_ba24 |
| rs202000850 | 6 | 42921489 | GNMT | ENSG00000124713.5 | 1.154E-6 | 0 | -7007 | gtex_brain_ba24 |
| rs58497441 | 6 | 42921561 | GNMT | ENSG00000124713.5 | 2.454E-8 | 0 | -6935 | gtex_brain_ba24 |
| rs56108053 | 6 | 42921673 | GNMT | ENSG00000124713.5 | 6.531E-7 | 0 | -6823 | gtex_brain_ba24 |
| rs6458313 | 6 | 42922018 | GNMT | ENSG00000124713.5 | 2.105E-8 | 0 | -6478 | gtex_brain_ba24 |
| rs6458314 | 6 | 42922215 | GNMT | ENSG00000124713.5 | 7.346E-9 | 0 | -6281 | gtex_brain_ba24 |
| rs6458315 | 6 | 42922547 | GNMT | ENSG00000124713.5 | 2.708E-8 | 0 | -5949 | gtex_brain_ba24 |
| rs12524845 | 6 | 42923902 | GNMT | ENSG00000124713.5 | 2.477E-8 | 0 | -4594 | gtex_brain_ba24 |
| rs112122607 | 6 | 42924041 | GNMT | ENSG00000124713.5 | 2.452E-8 | 0 | -4455 | gtex_brain_ba24 |
| rs13215983 | 6 | 42924193 | GNMT | ENSG00000124713.5 | 2.425E-8 | 0 | -4303 | gtex_brain_ba24 |
| rs13216214 | 6 | 42924247 | GNMT | ENSG00000124713.5 | 2.411E-8 | 0 | -4249 | gtex_brain_ba24 |
| rs4714640 | 6 | 42924424 | GNMT | ENSG00000124713.5 | 2.366E-8 | 0 | -4072 | gtex_brain_ba24 |
| rs70990160 | 6 | 42924488 | GNMT | ENSG00000124713.5 | 1.832E-8 | 0 | -4008 | gtex_brain_ba24 |
| rs4714641 | 6 | 42924622 | GNMT | ENSG00000124713.5 | 2.175E-8 | 0 | -3874 | gtex_brain_ba24 |
| rs56038104 | 6 | 42924894 | GNMT | ENSG00000124713.5 | 1.985E-6 | 0 | -3602 | gtex_brain_ba24 |
| rs6940814 | 6 | 42924932 | GNMT | ENSG00000124713.5 | 8.725E-9 | 0 | -3564 | gtex_brain_ba24 |
| rs6920547 | 6 | 42924955 | GNMT | ENSG00000124713.5 | 2.222E-8 | 0 | -3541 | gtex_brain_ba24 |
| rs6940837 | 6 | 42924969 | GNMT | ENSG00000124713.5 | 2.217E-8 | 0 | -3527 | gtex_brain_ba24 |
| rs9296403 | 6 | 42925683 | GNMT | ENSG00000124713.5 | 5.657E-7 | 0 | -2813 | gtex_brain_ba24 |
| rs9296404 | 6 | 42925803 | GNMT | ENSG00000124713.5 | 2.048E-8 | 0 | -2693 | gtex_brain_ba24 |
| rs9462855 | 6 | 42925936 | GNMT | ENSG00000124713.5 | 2.025E-8 | 0 | -2560 | gtex_brain_ba24 |
| rs9462856 | 6 | 42926024 | GNMT | ENSG00000124713.5 | 1.5E-8 | 0 | -2472 | gtex_brain_ba24 |
| rs370513007 | 6 | 42926477 | GNMT | ENSG00000124713.5 | 5.183E-7 | 0 | -2019 | gtex_brain_ba24 |
| rs11752813 | 6 | 42928017 | GNMT | ENSG00000124713.5 | 4.623E-7 | 0 | -479 | gtex_brain_ba24 |
| rs10948059 | 6 | 42928461 | GNMT | ENSG00000124713.5 | 5.509E-8 | 0 | -35 | gtex_brain_ba24 |
| rs2296805 | 6 | 42928758 | GNMT | ENSG00000124713.5 | 5.799E-9 | 0 | 262 | gtex_brain_ba24 |
| rs9471978 | 6 | 42929533 | GNMT | ENSG00000124713.5 | 5.696E-8 | 0 | 1037 | gtex_brain_ba24 |
| rs7760250 | 6 | 42929839 | GNMT | ENSG00000124713.5 | 1.65E-8 | 0 | 1343 | gtex_brain_ba24 |
| rs4987173 | 6 | 42931224 | GNMT | ENSG00000124713.5 | 4.076E-7 | 0 | 2728 | gtex_brain_ba24 |
| rs2296804 | 6 | 42931261 | GNMT | ENSG00000124713.5 | 5.224E-9 | 0 | 2765 | gtex_brain_ba24 |
| rs5875822 | 6 | 42931627 | GNMT | ENSG00000124713.5 | 5.146E-9 | 0 | 3131 | gtex_brain_ba24 |
| rs1129187 | 6 | 42932200 | GNMT | ENSG00000124713.5 | 3.923E-7 | 0 | 3704 | gtex_brain_ba24 |
| rs1129186 | 6 | 42932202 | GNMT | ENSG00000124713.5 | 1.508E-8 | 0 | 3706 | gtex_brain_ba24 |
| rs2274517 | 6 | 42932715 | GNMT | ENSG00000124713.5 | 1.504E-8 | 0 | 4219 | gtex_brain_ba24 |
| rs2274514 | 6 | 42934500 | GNMT | ENSG00000124713.5 | 2.707E-8 | 0 | 6004 | gtex_brain_ba24 |
| rs3818554 | 6 | 42934620 | GNMT | ENSG00000124713.5 | 4.78E-8 | 0 | 6124 | gtex_brain_ba24 |
| rs4714644 | 6 | 42934818 | GNMT | ENSG00000124713.5 | 2.839E-8 | 0 | 6322 | gtex_brain_ba24 |
| rs9471982 | 6 | 42935998 | GNMT | ENSG00000124713.5 | 1.504E-8 | 0 | 7502 | gtex_brain_ba24 |
| rs3805953 | 6 | 42936900 | GNMT | ENSG00000124713.5 | 3.163E-8 | 0 | 8404 | gtex_brain_ba24 |
| rs3805952 | 6 | 42937126 | GNMT | ENSG00000124713.5 | 1.137E-6 | 0 | 8630 | gtex_brain_ba24 |
| rs3805951 | 6 | 42937176 | GNMT | ENSG00000124713.5 | 1.163E-6 | 0 | 8680 | gtex_brain_ba24 |
| rs3293 | 6 | 42938377 | GNMT | ENSG00000124713.5 | 4.78E-8 | 0 | 9881 | gtex_brain_ba24 |
| rs10948061 | 6 | 42940235 | GNMT | ENSG00000124713.5 | 1.161E-6 | 0 | 11739 | gtex_brain_ba24 |
| rs9471983 | 6 | 42940365 | GNMT | ENSG00000124713.5 | 1.161E-6 | 0 | 11869 | gtex_brain_ba24 |
| rs200189441 | 6 | 42940524 | GNMT | ENSG00000124713.5 | 9.519E-9 | 0 | 12028 | gtex_brain_ba24 |
| rs570622275 | 6 | 42940525 | GNMT | ENSG00000124713.5 | 4.781E-8 | 0 | 12029 | gtex_brain_ba24 |
| rs2395943 | 6 | 42940673 | GNMT | ENSG00000124713.5 | 1.831E-8 | 0 | 12177 | gtex_brain_ba24 |
| rs9296406 | 6 | 42940810 | GNMT | ENSG00000124713.5 | 3.665E-8 | 0 | 12314 | gtex_brain_ba24 |
| rs9471985 | 6 | 42941324 | GNMT | ENSG00000124713.5 | 4.753E-8 | 0 | 12828 | gtex_brain_ba24 |
| rs71855084 | 6 | 42942180 | GNMT | ENSG00000124713.5 | 1.953E-6 | 0 | 13684 | gtex_brain_ba24 |
| rs9296407 | 6 | 42942451 | GNMT | ENSG00000124713.5 | 4.713E-8 | 0 | 13955 | gtex_brain_ba24 |
| rs9462857 | 6 | 42943098 | GNMT | ENSG00000124713.5 | 1.142E-6 | 0 | 14602 | gtex_brain_ba24 |
| rs9471986 | 6 | 42944127 | GNMT | ENSG00000124713.5 | 5.345E-9 | 0 | 15631 | gtex_brain_ba24 |
| rs9471987 | 6 | 42944140 | GNMT | ENSG00000124713.5 | 6.708E-9 | 0 | 15644 | gtex_brain_ba24 |
| rs9471988 | 6 | 42944773 | GNMT | ENSG00000124713.5 | 3.464E-8 | 0 | 16277 | gtex_brain_ba24 |
| rs6907751 | 6 | 42944850 | GNMT | ENSG00000124713.5 | 1.53E-7 | 0 | 16354 | gtex_brain_ba24 |
| rs200735142 | 6 | 42944988 | GNMT | ENSG00000124713.5 | 2.987E-8 | 0 | 16492 | gtex_brain_ba24 |
| rs201802248 | 6 | 42945582 | GNMT | ENSG00000124713.5 | 3.973E-7 | 0 | 17086 | gtex_brain_ba24 |
| rs199921136 | 6 | 42945583 | GNMT | ENSG00000124713.5 | 1.846E-7 | 0 | 17087 | gtex_brain_ba24 |
| rs9462858 | 6 | 42946490 | GNMT | ENSG00000124713.5 | 1.092E-6 | 0 | 17994 | gtex_brain_ba24 |
| rs9462859 | 6 | 42946943 | GNMT | ENSG00000124713.5 | 1.068E-6 | 0 | 18447 | gtex_brain_ba24 |
| rs9462860 | 6 | 42947013 | GNMT | ENSG00000124713.5 | 2.109E-8 | 0 | 18517 | gtex_brain_ba24 |
| rs3805946 | 6 | 42955749 | GNMT | ENSG00000124713.5 | 5.619E-7 | 0 | 27253 | gtex_brain_ba24 |
| rs2007950 | 6 | 43049461 | GNMT | ENSG00000124713.5 | 8.385E-7 | 0 | 120965 | gtex_brain_ba24 |
| rs9471972 | 6 | 42915021 | GNMT | ENSG00000124713.5 | 2.253E-6 | 0 | -13475 | gtex_brain_putamen_basal |
| rs6941212 | 6 | 42915920 | GNMT | ENSG00000124713.5 | 1.348E-7 | 0 | -12576 | gtex_brain_putamen_basal |
| rs4714638 | 6 | 42917017 | GNMT | ENSG00000124713.5 | 3.254E-7 | 0 | -11479 | gtex_brain_putamen_basal |
| rs9471974 | 6 | 42918984 | GNMT | ENSG00000124713.5 | 6.881E-9 | 0 | -9512 | gtex_brain_putamen_basal |
| rs9471975 | 6 | 42919222 | GNMT | ENSG00000124713.5 | 8.664E-8 | 0 | -9274 | gtex_brain_putamen_basal |
| rs2104616 | 6 | 42919969 | GNMT | ENSG00000124713.5 | 3.627E-8 | 0 | -8527 | gtex_brain_putamen_basal |
| rs59824590 | 6 | 42920416 | GNMT | ENSG00000124713.5 | 8.037E-8 | 0 | -8080 | gtex_brain_putamen_basal |
| rs9471976 | 6 | 42920549 | GNMT | ENSG00000124713.5 | 1.468E-7 | 0 | -7947 | gtex_brain_putamen_basal |
| rs4469287 | 6 | 42920844 | GNMT | ENSG00000124713.5 | 1.703E-7 | 0 | -7652 | gtex_brain_putamen_basal |
| rs28868299 | 6 | 42921221 | GNMT | ENSG00000124713.5 | 2.636E-7 | 0 | -7275 | gtex_brain_putamen_basal |
| rs145239038 | 6 | 42921474 | GNMT | ENSG00000124713.5 | 1.25E-7 | 0 | -7022 | gtex_brain_putamen_basal |
| rs58497441 | 6 | 42921561 | GNMT | ENSG00000124713.5 | 1.274E-7 | 0 | -6935 | gtex_brain_putamen_basal |
| rs56108053 | 6 | 42921673 | GNMT | ENSG00000124713.5 | 5.456E-9 | 0 | -6823 | gtex_brain_putamen_basal |
| rs6458313 | 6 | 42922018 | GNMT | ENSG00000124713.5 | 2.755E-7 | 0 | -6478 | gtex_brain_putamen_basal |
| rs6458314 | 6 | 42922215 | GNMT | ENSG00000124713.5 | 1.236E-7 | 0 | -6281 | gtex_brain_putamen_basal |
| rs6458315 | 6 | 42922547 | GNMT | ENSG00000124713.5 | 1.007E-6 | 0 | -5949 | gtex_brain_putamen_basal |
| rs12524845 | 6 | 42923902 | GNMT | ENSG00000124713.5 | 1.328E-7 | 0 | -4594 | gtex_brain_putamen_basal |
| rs112122607 | 6 | 42924041 | GNMT | ENSG00000124713.5 | 1.322E-7 | 0 | -4455 | gtex_brain_putamen_basal |
| rs13215983 | 6 | 42924193 | GNMT | ENSG00000124713.5 | 1.315E-7 | 0 | -4303 | gtex_brain_putamen_basal |
| rs13216214 | 6 | 42924247 | GNMT | ENSG00000124713.5 | 1.314E-7 | 0 | -4249 | gtex_brain_putamen_basal |
| rs4714640 | 6 | 42924424 | GNMT | ENSG00000124713.5 | 1.303E-7 | 0 | -4072 | gtex_brain_putamen_basal |
| rs70990160 | 6 | 42924488 | GNMT | ENSG00000124713.5 | 1.193E-7 | 0 | -4008 | gtex_brain_putamen_basal |
| rs4714641 | 6 | 42924622 | GNMT | ENSG00000124713.5 | 1.311E-7 | 0 | -3874 | gtex_brain_putamen_basal |
| rs56038104 | 6 | 42924894 | GNMT | ENSG00000124713.5 | 1.129E-7 | 0 | -3602 | gtex_brain_putamen_basal |
| rs6920547 | 6 | 42924955 | GNMT | ENSG00000124713.5 | 9.795E-7 | 0 | -3541 | gtex_brain_putamen_basal |
| rs6940837 | 6 | 42924969 | GNMT | ENSG00000124713.5 | 1.324E-7 | 0 | -3527 | gtex_brain_putamen_basal |
| rs9296403 | 6 | 42925683 | GNMT | ENSG00000124713.5 | 1.351E-8 | 0 | -2813 | gtex_brain_putamen_basal |
| rs9296404 | 6 | 42925803 | GNMT | ENSG00000124713.5 | 1.231E-7 | 0 | -2693 | gtex_brain_putamen_basal |
| rs9462855 | 6 | 42925936 | GNMT | ENSG00000124713.5 | 1.227E-7 | 0 | -2560 | gtex_brain_putamen_basal |
| rs9462856 | 6 | 42926024 | GNMT | ENSG00000124713.5 | 2.391E-7 | 0 | -2472 | gtex_brain_putamen_basal |
| rs370513007 | 6 | 42926477 | GNMT | ENSG00000124713.5 | 5.299E-9 | 0 | -2019 | gtex_brain_putamen_basal |
| rs11752813 | 6 | 42928017 | GNMT | ENSG00000124713.5 | 5.162E-9 | 0 | -479 | gtex_brain_putamen_basal |
| rs10948059 | 6 | 42928461 | GNMT | ENSG00000124713.5 | 4.617E-8 | 0 | -35 | gtex_brain_putamen_basal |
| rs2296805 | 6 | 42928758 | GNMT | ENSG00000124713.5 | 7.276E-8 | 0 | 262 | gtex_brain_putamen_basal |
| rs7760250 | 6 | 42929839 | GNMT | ENSG00000124713.5 | 1.151E-7 | 0 | 1343 | gtex_brain_putamen_basal |
| rs4987173 | 6 | 42931224 | GNMT | ENSG00000124713.5 | 5.179E-9 | 0 | 2728 | gtex_brain_putamen_basal |
| rs2296804 | 6 | 42931261 | GNMT | ENSG00000124713.5 | 7.353E-8 | 0 | 2765 | gtex_brain_putamen_basal |
| rs5875822 | 6 | 42931627 | GNMT | ENSG00000124713.5 | 7.315E-8 | 0 | 3131 | gtex_brain_putamen_basal |
| rs1129187 | 6 | 42932200 | GNMT | ENSG00000124713.5 | 5.198E-9 | 0 | 3704 | gtex_brain_putamen_basal |
| rs1129186 | 6 | 42932202 | GNMT | ENSG00000124713.5 | 1.14E-7 | 0 | 3706 | gtex_brain_putamen_basal |
| rs2274517 | 6 | 42932715 | GNMT | ENSG00000124713.5 | 8.746E-7 | 0 | 4219 | gtex_brain_putamen_basal |
| rs2274514 | 6 | 42934500 | GNMT | ENSG00000124713.5 | 1.356E-7 | 0 | 6004 | gtex_brain_putamen_basal |
| rs3818554 | 6 | 42934620 | GNMT | ENSG00000124713.5 | 1.788E-7 | 0 | 6124 | gtex_brain_putamen_basal |
| rs4714644 | 6 | 42934818 | GNMT | ENSG00000124713.5 | 1.026E-6 | 0 | 6322 | gtex_brain_putamen_basal |
| rs9471982 | 6 | 42935998 | GNMT | ENSG00000124713.5 | 8.746E-7 | 0 | 7502 | gtex_brain_putamen_basal |
| rs3805953 | 6 | 42936900 | GNMT | ENSG00000124713.5 | 3.294E-7 | 0 | 8404 | gtex_brain_putamen_basal |
| rs3805952 | 6 | 42937126 | GNMT | ENSG00000124713.5 | 7.736E-9 | 0 | 8630 | gtex_brain_putamen_basal |
| rs3805951 | 6 | 42937176 | GNMT | ENSG00000124713.5 | 7.855E-9 | 0 | 8680 | gtex_brain_putamen_basal |
| rs3293 | 6 | 42938377 | GNMT | ENSG00000124713.5 | 1.239E-6 | 0 | 9881 | gtex_brain_putamen_basal |
| rs10948061 | 6 | 42940235 | GNMT | ENSG00000124713.5 | 7.855E-9 | 0 | 11739 | gtex_brain_putamen_basal |
| rs9471983 | 6 | 42940365 | GNMT | ENSG00000124713.5 | 7.855E-9 | 0 | 11869 | gtex_brain_putamen_basal |
| rs200189441 | 6 | 42940524 | GNMT | ENSG00000124713.5 | 1.784E-7 | 0 | 12028 | gtex_brain_putamen_basal |
| rs570622275 | 6 | 42940525 | GNMT | ENSG00000124713.5 | 1.148E-6 | 0 | 12029 | gtex_brain_putamen_basal |
| rs2395943 | 6 | 42940673 | GNMT | ENSG00000124713.5 | 9.649E-8 | 0 | 12177 | gtex_brain_putamen_basal |
| rs9296406 | 6 | 42940810 | GNMT | ENSG00000124713.5 | 3.695E-7 | 0 | 12314 | gtex_brain_putamen_basal |
| rs9471985 | 6 | 42941324 | GNMT | ENSG00000124713.5 | 1.235E-6 | 0 | 12828 | gtex_brain_putamen_basal |
| rs9296407 | 6 | 42942451 | GNMT | ENSG00000124713.5 | 1.227E-6 | 0 | 13955 | gtex_brain_putamen_basal |
| rs9986447 | 6 | 42942779 | GNMT | ENSG00000124713.5 | 3.494E-8 | 0 | 14283 | gtex_brain_putamen_basal |
| rs9462857 | 6 | 42943098 | GNMT | ENSG00000124713.5 | 7.723E-9 | 0 | 14602 | gtex_brain_putamen_basal |
| rs9471987 | 6 | 42944140 | GNMT | ENSG00000124713.5 | 2.567E-6 | 0 | 15644 | gtex_brain_putamen_basal |
| rs9471988 | 6 | 42944773 | GNMT | ENSG00000124713.5 | 8.598E-7 | 0 | 16277 | gtex_brain_putamen_basal |
| rs6907751 | 6 | 42944850 | GNMT | ENSG00000124713.5 | 2.017E-8 | 0 | 16354 | gtex_brain_putamen_basal |
| rs200735142 | 6 | 42944988 | GNMT | ENSG00000124713.5 | 2.583E-7 | 0 | 16492 | gtex_brain_putamen_basal |
| rs201802248 | 6 | 42945582 | GNMT | ENSG00000124713.5 | 6.849E-7 | 0 | 17086 | gtex_brain_putamen_basal |
| rs199921136 | 6 | 42945583 | GNMT | ENSG00000124713.5 | 6.722E-7 | 0 | 17087 | gtex_brain_putamen_basal |
| rs9462858 | 6 | 42946490 | GNMT | ENSG00000124713.5 | 1.03E-7 | 0 | 17994 | gtex_brain_putamen_basal |
| rs9462859 | 6 | 42946943 | GNMT | ENSG00000124713.5 | 9.915E-8 | 0 | 18447 | gtex_brain_putamen_basal |
| rs13199873 | 6 | 43040368 | GNMT | ENSG00000124713.5 | 1.048E-6 | 0 | 111872 | gtex_brain_putamen_basal |
| rs2007950 | 6 | 43049461 | GNMT | ENSG00000124713.5 | 4.189E-7 | 0 | 120965 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005542 | folic acid binding | IEA | - | |
| GO:0016740 | transferase activity | IEA | - | |
| GO:0017174 | glycine N-methyltransferase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006464 | protein modification process | NAS | 10843803 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005737 | cytoplasm | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG GLYCINE SERINE AND THREONINE METABOLISM | 31 | 26 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| CHEBOTAEV GR TARGETS UP | 77 | 62 | All SZGR 2.0 genes in this pathway |
| PEREZ TP53 TARGETS | 1174 | 695 | All SZGR 2.0 genes in this pathway |
| FARMER BREAST CANCER APOCRINE VS LUMINAL | 326 | 213 | All SZGR 2.0 genes in this pathway |
| FARMER BREAST CANCER APOCRINE VS BASAL | 330 | 217 | All SZGR 2.0 genes in this pathway |
| SHETH LIVER CANCER VS TXNIP LOSS PAM4 | 261 | 153 | All SZGR 2.0 genes in this pathway |
| IGLESIAS E2F TARGETS DN | 16 | 11 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 TARGETS DN | 543 | 317 | All SZGR 2.0 genes in this pathway |
| MARTINEZ TP53 TARGETS DN | 593 | 372 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 AND TP53 TARGETS DN | 591 | 366 | All SZGR 2.0 genes in this pathway |
| ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN | 354 | 216 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | 863 | 514 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL DN | 701 | 446 | All SZGR 2.0 genes in this pathway |
| RAY TUMORIGENESIS BY ERBB2 CDC25A UP | 104 | 57 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3 UNMETHYLATED | 536 | 296 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K27ME3 | 269 | 159 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA DN | 267 | 160 | All SZGR 2.0 genes in this pathway |
| CAIRO LIVER DEVELOPMENT DN | 222 | 141 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3 UNMETHYLATED | 228 | 119 | All SZGR 2.0 genes in this pathway |
| BAKKER FOXO3 TARGETS DN | 187 | 109 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |
| ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN | 308 | 187 | All SZGR 2.0 genes in this pathway |