Gene Page: ANGPT2

Summary
GeneID  285
Symbol  ANGPT2
Synonyms  AGPT2|ANG2
Description  angiopoietin 2
See related  HGNC:485|MIM:601922|Ensembl:ENSG00000091879|HPRD:03563|
Locus tag  -
Gene type  protein-coding
Map location  8p23.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
LYST0.930.95
ASH1L0.920.94
MYO9A0.910.94
ZBTB380.910.94
HECTD10.910.93
ANK20.900.93
KIAA11090.890.92
ATRN0.890.92
CAMSAP1L10.890.92
SETX0.890.92
Top 10 negatively co-expressed genes
FXYD1-0.67-0.71
ENHO-0.67-0.78
HIGD1B-0.67-0.76
ACSF2-0.66-0.73
TLCD1-0.66-0.72
HSD17B14-0.66-0.71
S100A16-0.66-0.71
METRN-0.66-0.76
RHOC-0.66-0.74
AF347015.31-0.65-0.70
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingIEANeurotransmitter (GO term level: 4)-
GO:0005102receptor bindingTASNeurotransmitter (GO term level: 4)9204896 |10766762 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionIEA-
GO:0007165signal transductionTAS10766762 
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
GO:0016525negative regulation of angiogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceTAS10766762 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANGPT1AGP1 | AGPT | ANG1angiopoietin 1-HPRD,BioGRID9204896 
TEKCD202B | TIE-2 | TIE2 | VMCM | VMCM1TEK tyrosine kinase, endothelialThe receptor binding domain (RBD) of Ang2 interacts with the Tie2 ligand binding domain (LBD). This interaction was modelled on a demonstrated interaction between human Ang2 and Tie2 from an unspecified species.BIND15893672 
Tie2 interacts with Ang2.BIND15542434 
-HPRD,BioGRID9723709 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 5041All SZGR genes in this pathway
REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 9165All SZGR genes in this pathway
REACTOME_TIE2_SIGNALING 1713All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP 294178All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
ROY_WOUND_BLOOD_VESSEL_UP 5030All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_DN 310188All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_ADVANCED_VS_EARLY_UP 175120All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP 182110All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP 194122All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_UP 11578All SZGR genes in this pathway
GALIE_TUMOR_ANGIOGENESIS 87All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_MODERATELY_DN 11064All SZGR genes in this pathway
GUO_HEX_TARGETS_DN 6536All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_UP 13187All SZGR genes in this pathway
SUZUKI_RESPONSE_TO_TSA_AND_DECITABINE_1A 2316All SZGR genes in this pathway
HARRIS_HYPOXIA 8164All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_2 5034All SZGR genes in this pathway
WESTON_VEGFA_TARGETS 10871All SZGR genes in this pathway
ABE_VEGFA_TARGETS 2015All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
WESTON_VEGFA_TARGETS_3HR 7447All SZGR genes in this pathway
CLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_UP 2012All SZGR genes in this pathway
OSADA_ASCL1_TARGETS_UP 4630All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
BOQUEST_STEM_CELL_DN 216143All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_UP 10457All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_UP 293203All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3 445257All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_DN 244157All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_DN 418245All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1453313381A,m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-542-3p2892961A,m8hsa-miR-542-3pUGUGACAGAUUGAUAACUGAAA
miR-5433023091A,m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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