Gene Page: RNF212
Summary ?
| GeneID | 285498 |
| Symbol | RNF212 |
| Synonyms | ZHP3 |
| Description | ring finger protein 212 |
| Reference | MIM:612041|HGNC:HGNC:27729|Ensembl:ENSG00000178222|HPRD:14158|Vega:OTTHUMG00000118997 |
| Gene type | protein-coding |
| Map location | 4p16.3 |
| Pascal p-value | 0.114 |
| Fetal beta | -1.062 |
| DMG | 2 (# studies) |
| eGene | Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Montano_2016 | Genome-wide DNA methylation analysis | This dataset includes 172 replicated associations between CpGs with schizophrenia. | 3 |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 3 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg11977605 | 4 | 1076247 | RNF212 | 1.04E-5 | -0.006 | 0.045 | DMG:Montano_2016 |
| cg10134910 | 4 | 1076041 | RNF212 | 1.42E-4 | -0.006 | 0.139 | DMG:Montano_2016 |
| cg10134910 | 4 | 1076041 | RNF212 | 4.001E-4 | -0.314 | 0.044 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KOYAMA SEMA3B TARGETS DN | 411 | 249 | All SZGR 2.0 genes in this pathway |
| ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF | 516 | 308 | All SZGR 2.0 genes in this pathway |