Gene Page: GRIA2

Summary
GeneID  2891
Symbol  GRIA2
Synonyms  GLUR2|GLURB|GluR-K2|HBGR2
Description  glutamate receptor, ionotropic, AMPA 2
See related  HGNC:4572|MIM:138247|Ensembl:ENSG00000120251|HPRD:04726|
Locus tag  -
Gene type  protein-coding
Map location  4q32-q33
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenics, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 6 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.6626 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TACC10.940.89
ZMAT30.930.88
FAM73A0.920.81
CHIC10.910.80
MBNL20.900.87
EFR3A0.900.79
DPP80.900.78
NAPEPLD0.900.77
OXR10.890.79
ARAP20.890.88
Top 10 negatively co-expressed genes
BCL7C-0.48-0.65
TBC1D10A-0.48-0.44
TRAF4-0.46-0.63
AC006276.2-0.46-0.52
SH3BP2-0.46-0.57
SH2B2-0.45-0.56
RPL36-0.45-0.65
RPLP1-0.45-0.61
SIGIRR-0.45-0.57
NR2C2AP-0.45-0.50
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004971alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityTASglutamate (GO term level: 8)8003671 
GO:0004970ionotropic glutamate receptor activityIEAglutamate (GO term level: 7)-
GO:0005234extracellular-glutamate-gated ion channel activityIEAglutamate (GO term level: 11)-
GO:0015277kainate selective glutamate receptor activityTASglutamate (GO term level: 8)8003671 
GO:0004872receptor activityIEA-
GO:0005216ion channel activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)8003671 
GO:0007165signal transductionTAS8003671 
GO:0006811ion transportIEA-
GO:0006810transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneTAS8003671 
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CACNG2MGC138502 | MGC138504calcium channel, voltage-dependent, gamma subunit 2Affinity Capture-WesternBioGRID11140673 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)Affinity Capture-MSBioGRID16990550 
GRIA1GLUH1 | GLUR1 | GLURA | HBGR1 | MGC133252glutamate receptor, ionotropic, AMPA 1Affinity Capture-WesternBioGRID10358037 
GRID2MGC117022 | MGC117023 | MGC117024glutamate receptor, ionotropic, delta 2Affinity Capture-WesternBioGRID12573530 
GRIK2EAA4 | GLR6 | GLUK6 | GLUR6 | MGC74427 | MRT6glutamate receptor, ionotropic, kainate 2Affinity Capture-WesternBioGRID8288598 
GRIK5EAA2 | GRIK2 | KA2glutamate receptor, ionotropic, kainate 5Affinity Capture-WesternBioGRID12573530 
GRIP1GRIPglutamate receptor interacting protein 1Reconstituted Complex
Two-hybrid		BioGRID11891216 
PICK1MGC15204 | PICK | PRKCABPprotein interacting with PRKCA 1Reconstituted Complex
Two-hybrid		BioGRID11891216 
SDCBPMDA-9 | ST1 | SYCL | TACIP18syndecan binding protein (syntenin)Reconstituted ComplexBioGRID11891216 
SPTAN1(ALPHA)II-SPECTRIN | FLJ44613 | NEASspectrin, alpha, non-erythrocytic 1 (alpha-fodrin)Affinity Capture-Western
Far Western		BioGRID10576550 
SPTBN1ELF | SPTB2 | betaSpIIspectrin, beta, non-erythrocytic 1Far WesternBioGRID10576550 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION 7057All SZGR genes in this pathway
KEGG_LONG_TERM_DEPRESSION 7053All SZGR genes in this pathway
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 5343All SZGR genes in this pathway
PID_NCADHERIN_PATHWAY 3332All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS 2823All SZGR genes in this pathway
REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS 1611All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS 3732All SZGR genes in this pathway
REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION 1514All SZGR genes in this pathway
TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP 9459All SZGR genes in this pathway
GUENTHER_GROWTH_SPHERICAL_VS_ADHERENT_UP 2115All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
CHESLER_BRAIN_HIGHEST_EXPRESSION 4029All SZGR genes in this pathway
ABBUD_LIF_SIGNALING_1_DN 2617All SZGR genes in this pathway
MCCLUNG_DELTA_FOSB_TARGETS_8WK 4738All SZGR genes in this pathway
MODY_HIPPOCAMPUS_POSTNATAL 6350All SZGR genes in this pathway
JIANG_AGING_CEREBRAL_CORTEX_UP 3627All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
RAMALHO_STEMNESS_DN 7455All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
LEIN_NEURON_MARKERS 6945All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_DN 12081All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_UP 172109All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP 14985All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_UP 293203All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_DN 13483All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL 177132All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.1188194m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5061871941A,m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-132/212234323491Ahsa-miR-212SZUAACAGUCUCCAGUCACGGCC
hsa-miR-132brainUAACAGUCUACAGCCAUGGUCG
miR-181140146m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-1867797861A,m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-218476482m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-219198819941Ahsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-30-5p241724241A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-3354564621Ahsa-miR-335brainUCAAGAGCAAUAACGAAAAAUGU
miR-374128412901Ahsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-41020972103m8hsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-48648541Ahsa-miR-486UCCUGUACUGAGCUGCCCCGAG
miR-496209020961Ahsa-miR-496AUUACAUGGCCAAUCUC
hsa-miR-496AUUACAUGGCCAAUCUC
hsa-miR-496AUUACAUGGCCAAUCUC
hsa-miR-496AUUACAUGGCCAAUCUC
hsa-miR-496AUUACAUGGCCAAUCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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