SZGR2

Summary ?

GeneID	2891
Symbol	GRIA2
Synonyms	GLUR2\|GLURB\|GluA2\|GluR-K2\|HBGR2
Description	glutamate ionotropic receptor AMPA type subunit 2
Reference	MIM:138247\|HGNC:HGNC:4572\|Ensembl:ENSG00000120251\|HPRD:04726\|Vega:OTTHUMG00000133836
Gene type	protein-coding
Map location	4q32.1
Pascal p-value	0.235
Sherlock p-value	0.755
Fetal beta	-0.172
Support	LIGAND GATED ION SIGNALING G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.human_TAP-PSD-95-CORE G2Cdb.humanARC G2Cdb.humanPSD G2Cdb.humanPSP Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 6
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.6626

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
TACC1	0.94	0.89
ZMAT3	0.93	0.88
FAM73A	0.92	0.81
CHIC1	0.91	0.80
MBNL2	0.90	0.87
EFR3A	0.90	0.79
DPP8	0.90	0.78
NAPEPLD	0.90	0.77
OXR1	0.89	0.79
ARAP2	0.89	0.88

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
BCL7C	-0.48	-0.65
TBC1D10A	-0.48	-0.44
TRAF4	-0.46	-0.63
AC006276.2	-0.46	-0.52
SH3BP2	-0.46	-0.57
SH2B2	-0.45	-0.56
RPL36	-0.45	-0.65
RPLP1	-0.45	-0.61
SIGIRR	-0.45	-0.57
NR2C2AP	-0.45	-0.50

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004971	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	TAS	glutamate (GO term level: 8)	8003671
GO:0004970	ionotropic glutamate receptor activity	IEA	glutamate (GO term level: 7)	-
GO:0005234	extracellular-glutamate-gated ion channel activity	IEA	glutamate (GO term level: 11)	-
GO:0015277	kainate selective glutamate receptor activity	TAS	glutamate (GO term level: 8)	8003671
GO:0004872	receptor activity	IEA		-
GO:0005216	ion channel activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007268	synaptic transmission	TAS	neuron, Synap, Neurotransmitter (GO term level: 6)	8003671
GO:0007165	signal transduction	TAS		8003671
GO:0006811	ion transport	IEA		-
GO:0006810	transport	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0045211	postsynaptic membrane	IEA	Synap, Neurotransmitter (GO term level: 5)	-
GO:0045202	synapse	IEA	neuron, Synap, Neurotransmitter, Glial (GO term level: 2)	-
GO:0016020	membrane	IEA		-
GO:0016021	integral to membrane	IEA		-
GO:0005886	plasma membrane	TAS		8003671
GO:0030054	cell junction	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CACNG2	MGC138502 \| MGC138504	calcium channel, voltage-dependent, gamma subunit 2	Affinity Capture-Western	BioGRID	11140673
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	discs, large homolog 4 (Drosophila)	Affinity Capture-MS	BioGRID	16990550
GRIA1	GLUH1 \| GLUR1 \| GLURA \| HBGR1 \| MGC133252	glutamate receptor, ionotropic, AMPA 1	Affinity Capture-Western	BioGRID	10358037
GRID2	MGC117022 \| MGC117023 \| MGC117024	glutamate receptor, ionotropic, delta 2	Affinity Capture-Western	BioGRID	12573530
GRIK2	EAA4 \| GLR6 \| GLUK6 \| GLUR6 \| MGC74427 \| MRT6	glutamate receptor, ionotropic, kainate 2	Affinity Capture-Western	BioGRID	8288598
GRIK5	EAA2 \| GRIK2 \| KA2	glutamate receptor, ionotropic, kainate 5	Affinity Capture-Western	BioGRID	12573530
GRIP1	GRIP	glutamate receptor interacting protein 1	Reconstituted Complex Two-hybrid	BioGRID	11891216
PICK1	MGC15204 \| PICK \| PRKCABP	protein interacting with PRKCA 1	Reconstituted Complex Two-hybrid	BioGRID	11891216
SDCBP	MDA-9 \| ST1 \| SYCL \| TACIP18	syndecan binding protein (syntenin)	Reconstituted Complex	BioGRID	11891216
SPTAN1	(ALPHA)II-SPECTRIN \| FLJ44613 \| NEAS	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	Affinity Capture-Western Far Western	BioGRID	10576550
SPTBN1	ELF \| SPTB2 \| betaSpII	spectrin, beta, non-erythrocytic 1	Far Western	BioGRID	10576550

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION	272	195	All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION	70	57	All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION	70	53	All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS	53	43	All SZGR 2.0 genes in this pathway
PID NCADHERIN PATHWAY	33	32	All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	186	155	All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM	279	221	All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL	137	110	All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING OF AMPA RECEPTORS	28	23	All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	16	11	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS	37	32	All SZGR 2.0 genes in this pathway
REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	15	14	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL UP	94	59	All SZGR 2.0 genes in this pathway
GUENTHER GROWTH SPHERICAL VS ADHERENT UP	21	15	All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS	1038	678	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3	1118	744	All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS	652	441	All SZGR 2.0 genes in this pathway
CHESLER BRAIN HIGHEST EXPRESSION	40	29	All SZGR 2.0 genes in this pathway
ABBUD LIF SIGNALING 1 DN	26	17	All SZGR 2.0 genes in this pathway
MCCLUNG DELTA FOSB TARGETS 8WK	47	38	All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS POSTNATAL	63	50	All SZGR 2.0 genes in this pathway
JIANG AGING CEREBRAL CORTEX UP	36	27	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS DN	74	55	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1	528	324	All SZGR 2.0 genes in this pathway
LEIN NEURON MARKERS	69	45	All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN	120	81	All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP	430	288	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B UP	172	109	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN	701	446	All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE UP	149	85	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN	366	257	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP	293	203	All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER DN	134	83	All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3	435	318	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3	590	403	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL	177	132	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	188	194	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	187	194	1A,m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	187	194	1A,m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-132/212	2343	2349	1A	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	2343	2349	1A	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-181	140	146	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-186	779	786	1A,m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-218	476	482	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-219	1988	1994	1A	hsa-miR-219^brain	UGAUUGUCCAAACGCAAUUCU
miR-30-5p	2417	2424	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-335	456	462	1A	hsa-miR-335^brain	UCAAGAGCAAUAACGAAAAAUGU
miR-374	1284	1290	1A	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-410	2097	2103	m8	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-486	48	54	1A	hsa-miR-486	UCCUGUACUGAGCUGCCCCGAG
miR-496	2090	2096	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
				hsa-miR-496	AUUACAUGGCCAAUCUC
				hsa-miR-496	AUUACAUGGCCAAUCUC
				hsa-miR-496	AUUACAUGGCCAAUCUC
				hsa-miR-496	AUUACAUGGCCAAUCUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: GRIA2