Gene Page: APEX1

Summary
GeneID  328
Symbol  APEX1
Synonyms  APE|APE-1|APE1|APEN|APEX|APX|HAP1|REF-1|REF1
Description  APEX nuclease (multifunctional DNA repair enzyme) 1
See related  HGNC:587|MIM:107748|Ensembl:ENSG00000100823|HPRD:00136|
Locus tag  -
Gene type  protein-coding
Map location  14q11.2-q12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.047 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0385 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
HOOK30.920.92
UTP14C0.910.92
TMF10.910.93
ZNF7910.890.91
CLPX0.890.90
RABGAP10.890.91
ATRX0.890.91
C9orf1020.890.91
SEC630.890.90
UGCGL10.880.91
Top 10 negatively co-expressed genes
AF347015.31-0.68-0.73
FXYD1-0.67-0.72
HIGD1B-0.67-0.73
MT-CO2-0.67-0.72
ENHO-0.66-0.77
AF347015.21-0.66-0.72
IFI27-0.66-0.72
METRN-0.64-0.71
CST3-0.63-0.70
AF347015.27-0.63-0.67
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000287magnesium ion bindingIEA-
GO:0003677DNA bindingIDA11286553 
GO:0003713transcription coactivator activityIDA9119221 
GO:0003714transcription corepressor activityTAS7961715 
GO:0003906DNA-(apurinic or apyrimidinic site) lyase activityTAS9119221 
GO:0005515protein bindingIPI12524539 |15518571 
GO:0004844uracil DNA N-glycosylase activityTAS10805771 
GO:0004520endodeoxyribonuclease activityTAS1722334 
GO:0004523ribonuclease H activityTAS11286553 
GO:0004528phosphodiesterase I activityTAS9119221 
GO:0016829lyase activityIEA-
GO:00084083'-5' exonuclease activityTAS11286553 
GO:0016491oxidoreductase activityIDA9119221 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006366transcription from RNA polymerase II promoterTAS1380454 
GO:0006284base-excision repairTAS11286553 
GO:0051101regulation of DNA bindingIDA9119221 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005813centrosomeIDA18029348 
GO:0005840ribosomeTAS12524539 
GO:0005622intracellularIEA-
GO:0005634nucleusIDA9119221 
GO:0005654nucleoplasmEXP9207062 |10559261 |11250913 
GO:0005737cytoplasmIEA-
GO:0005783endoplasmic reticulumTAS12524539 
GO:0048471perinuclear region of cytoplasmIDA12524539 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANP32AC15orf1 | I1PP2A | LANP | MAPM | MGC119787 | MGC150373 | PHAP1 | PHAPI | PP32acidic (leucine-rich) nuclear phosphoprotein 32 family, member AAffinity Capture-WesternBioGRID12524539 
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)Ref1 interacts weakly with p21 promoter.BIND15674341 
DCTN1DAP-150 | DP-150 | HMN7B | P135dynactin 1 (p150, glued homolog, Drosophila)-HPRD9361024 
FEN1FEN-1 | MF1 | RAD2flap structure-specific endonuclease 1-HPRD,BioGRID11601988 
HIF1AHIF-1alpha | HIF1 | HIF1-ALPHA | MOP1 | PASD8hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)-HPRD,BioGRID10594042 
HMGB2HMG2high-mobility group box 2-HPRD12524539 
HNRNPLFLJ35509 | HNRPL | P/OKcl.14 | hnRNP-Lheterogeneous nuclear ribonucleoprotein L-HPRD,BioGRID11809897 
HSPA1AFLJ54303 | FLJ54370 | FLJ54392 | FLJ54408 | FLJ75127 | HSP70-1 | HSP70-1A | HSP70I | HSP72 | HSPA1 | HSPA1Bheat shock 70kDa protein 1A-HPRD11133992 
MUTYHMGC4416 | MYHmutY homolog (E. coli)hMYH is associated in vivo with apurinic/apyrimidinic endonuclease (APE1)BIND11092888 
-HPRD,BioGRID11092888 
NME1AWD | GAAD | NB | NBS | NDPK-A | NDPKA | NM23 | NM23-H1non-metastatic cells 1, protein (NM23A) expressed in-HPRD12524539 
PCNAMGC8367proliferating cell nuclear antigen-HPRD,BioGRID11601988 
SET2PP2A | I2PP2A | IGAAD | IPP2A2 | PHAPII | TAF-I | TAF-IBETASET nuclear oncogene-HPRD12628186 
Affinity Capture-WesternBioGRID12524539 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53p53 interacts with Ref-1.BIND15824742 
-HPRD,BioGRID9119221 
TXNDKFZp686B1993 | MGC61975 | TRX | TRX1thioredoxin-HPRD10585464|11118054 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)-HPRD,BioGRID12110916 
XRCC1RCCX-ray repair complementing defective repair in Chinese hamster cells 1-HPRD,BioGRID11707423 
XRCC5FLJ39089 | KARP-1 | KARP1 | KU80 | KUB2 | Ku86 | NFIVX-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)Reconstituted ComplexBioGRID8621488 
XRCC6CTC75 | CTCBF | G22P1 | KU70 | ML8 | TLAAX-ray repair complementing defective repair in Chinese hamster cells 6-HPRD8621488 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_BASE_EXCISION_REPAIR 3522All SZGR genes in this pathway
BIOCARTA_SET_PATHWAY 116All SZGR genes in this pathway
PID_HIF2PATHWAY 3429All SZGR genes in this pathway
REACTOME_BASE_EXCISION_REPAIR 1913All SZGR genes in this pathway
REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY 1711All SZGR genes in this pathway
REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY 105All SZGR genes in this pathway
REACTOME_DNA_REPAIR 11259All SZGR genes in this pathway
REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY 127All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN 362238All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_SKIN_UP 177113All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
WAKASUGI_HAVE_ZNF143_BINDING_SITES 5833All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
MENSSEN_MYC_TARGETS 5335All SZGR genes in this pathway
SMITH_TERT_TARGETS_DN 8769All SZGR genes in this pathway
SANA_RESPONSE_TO_IFNG_DN 8556All SZGR genes in this pathway
FERRANDO_LYL1_NEIGHBORS 1512All SZGR genes in this pathway
SANSOM_APC_TARGETS_UP 12684All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_DN 12986All SZGR genes in this pathway
NEMETH_INFLAMMATORY_RESPONSE_LPS_DN 3225All SZGR genes in this pathway
NGUYEN_NOTCH1_TARGETS_DN 8667All SZGR genes in this pathway
JAZAERI_BREAST_CANCER_BRCA1_VS_BRCA2_DN 4331All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_HEREDITARY_VS_SPORADIC 5032All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
HARRIS_HYPOXIA 8164All SZGR genes in this pathway
PAL_PRMT5_TARGETS_UP 203135All SZGR genes in this pathway
HU_GENOTOXIN_ACTION_DIRECT_VS_INDIRECT_24HR 5538All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_INTERMEDIATE_PROGENITOR 14984All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_DN 14192All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_DN 10164All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_4 307185All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
ALONSO_METASTASIS_UP 198128All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
IRITANI_MAD1_TARGETS_DN 4730All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
DANG_MYC_TARGETS_UP 143100All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE 335193All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_14 14386All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
DELPUECH_FOXO3_TARGETS_DN 4127All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway


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