Gene Page: HTR2C

Summary
GeneID  3358
Symbol  HTR2C
Synonyms  5-HT2C|5-HTR2C|HTR1C
Description  5-hydroxytryptamine (serotonin) receptor 2C
See related  HGNC:5295|MIM:312861|Ensembl:ENSG00000147246|HPRD:02429|
Locus tag  RP11-810O3.1
Gene type  protein-coding
Map location  Xq24
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenia, schizophrenias]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0005515protein bindingIPI16319069 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)9241279 
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007165signal transductionIEA-
GO:0007631feeding behaviorTAS7700379 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA18029348 
GO:0005737cytoplasmIDA18029348 
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APBA1D9S411E | MINT1 | X11 | X11A | X11ALPHAamyloid beta (A4) precursor protein-binding, family A, member 1-HPRD,BioGRID12006486 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD,BioGRID12006486 
LIN7CFLJ11215 | LIN-7-C | LIN-7C | MALS-3 | MALS3 | VELI3lin-7 homolog C (C. elegans)-HPRD,BioGRID12006486 
MPDZDKFZp781P216 | FLJ25909 | FLJ34626 | FLJ90240 | MUPP1multiple PDZ domain proteinAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9537516 |11150294 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_GAP_JUNCTION 9068All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_AMINE_LIGAND_BINDING_RECEPTORS 3833All SZGR genes in this pathway
REACTOME_SEROTONIN_RECEPTORS 1211All SZGR genes in this pathway
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 184116All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN 205127All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_DN 11879All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_UP 14984All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
LEIN_MIDBRAIN_MARKERS 8255All SZGR genes in this pathway
LEIN_PONS_MARKERS 8959All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MIKKELSEN_IPS_WITH_HCP_H3K27ME3 10276All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED 228119All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.124952501m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/506249525011Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-137217921851Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-1403903961Ahsa-miR-140brainAGUGGUUUUACCCUAUGGUAG
miR-1433313381A,m8hsa-miR-143brainUGAGAUGAAGCACUGUAGCUCA
miR-15/16/195/424/49713391345m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-182173217381Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-21413371343m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-216164170m8hsa-miR-216UAAUCUCAGCUGGCAACUGUG
miR-2191451511Ahsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-22121512211Ahsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-23107710841A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-323107710831Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-324-3p16711677m8hsa-miR-324-3pCCACUGCCCCAGGUGCUGCUGG
miR-326826832m8hsa-miR-326CCUCUGGGCCCUUCCUCCAG
miR-34/449172917361A,m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-34b24932499m8hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
miR-37917851791m8hsa-miR-379brainUGGUAGACUAUGGAACGUA
miR-38444501Ahsa-miR-384AUUCCUAGAAAUUGUUCAUA
miR-455191719231Ahsa-miR-455UAUGUGCCUUUGGACUACAUCG
miR-485-3p231423201Ahsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
miR-495221322191Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-49686921Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-96173217381Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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