Gene Page: IGF1

Summary
GeneID  3479
Symbol  IGF1
Synonyms  IGFI
Description  insulin-like growth factor 1 (somatomedin C)
See related  HGNC:5464|MIM:147440|Ensembl:ENSG00000017427|HPRD:00936|
Locus tag  -
Gene type  protein-coding
Map location  12q22-q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005179hormone activityIEA-
GO:0005179hormone activityTAS9681507 
GO:0005159insulin-like growth factor receptor bindingIPI8452530 
GO:0005159insulin-like growth factor receptor bindingTAS10749889 
GO:0005158insulin receptor bindingIPI8452530 
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI10766744 
GO:0008083growth factor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0010001glial cell differentiationIEAGlial (GO term level: 8)-
GO:0007399nervous system developmentIEAneurite (GO term level: 5)-
GO:0001501skeletal system developmentTAS10448861 
GO:0030104water homeostasisIEA-
GO:0007265Ras protein signal transductionTAS10848592 
GO:0006260DNA replicationTAS10766744 
GO:0009887organ morphogenesisIEA-
GO:0007165signal transductionTAS10448861 
GO:0048468cell developmentIEA-
GO:0007517muscle developmentTAS10448861 
GO:0007605sensory perception of soundIEA-
GO:0009441glycolate metabolic processTAS10448861 
GO:0048015phosphoinositide-mediated signalingIDA7692086 
GO:0006928cell motionTAS10766744 
GO:0006916anti-apoptosisIDA16942485 
GO:0006916anti-apoptosisIEA-
GO:0014065phosphoinositide 3-kinase cascadeIDA7688386 
GO:0042523positive regulation of tyrosine phosphorylation of Stat5 proteinIDA9722506 
GO:0033143regulation of steroid hormone receptor signaling pathwayIDA10459853 
GO:0014834satellite cell maintenance involved in skeletal muscle regenerationIDA17531227 
GO:0014896muscle hypertrophyIMP10191278 
GO:0014904myotube cell developmentIDA17531227 
GO:0014911positive regulation of smooth muscle cell migrationIDA10766744 
GO:0021940positive regulation of granule cell precursor proliferationIEA-
GO:0043193positive regulation of gene-specific transcriptionIDA9722506 
GO:0048754branching morphogenesis of a tubeIEA-
GO:0051246regulation of protein metabolic processIEA-
GO:0030879mammary gland developmentIEA-
GO:0034392negative regulation of smooth muscle cell apoptosisIDA16942485 
GO:0035264multicellular organism growthIEA-
GO:0045740positive regulation of DNA replicationIDA7688386 |9722506 
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
GO:0045840positive regulation of mitosisIDA7188854 
GO:0048146positive regulation of fibroblast proliferationIDA7188854 
GO:0050650chondroitin sulfate proteoglycan biosynthetic processIEA-
GO:0050679positive regulation of epithelial cell proliferationIDA7188854 
GO:0045821positive regulation of glycolysisIDA7688386 
GO:0043568positive regulation of insulin-like growth factor receptor signaling pathwayIDA7688386 |10766744 
GO:0046579positive regulation of Ras protein signal transductionIDA9722506 
GO:0048661positive regulation of smooth muscle cell proliferationIDA10766744 |16942485 
GO:0045445myoblast differentiationIDA17531227 
GO:0051450myoblast proliferationIDA17531227 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP2752154 
GO:0005576extracellular regionIEA-
GO:0005576extracellular regionNAS14718574 
GO:0005615extracellular spaceIEA-
GO:0016942insulin-like growth factor binding protein complexIC10766744 
GO:0031093platelet alpha granule lumenEXP2752154 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
IDEFLJ35968 | INSULYSINinsulin-degrading enzymeReconstituted ComplexBioGRID1733942 
IGF1RCD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216insulin-like growth factor 1 receptorIGF-I interacts with IGF-IR. This interaction was modeled on a demonstrated interaction between IGF-I from an unspecified species and human IGF-IR.BIND15604363 
-HPRD,BioGRID1852007 
IGFALSALSinsulin-like growth factor binding protein, acid labile subunit-HPRD,BioGRID9497324 |10823924 
IGFBP1AFBP | IBP1 | IGF-BP25 | PP12 | hIGFBP-1insulin-like growth factor binding protein 1-HPRD,BioGRID10350456 
IGF-I interacts with IGFBP-1.BIND10407151 
IGFBP2IBP2 | IGF-BP53insulin-like growth factor binding protein 2, 36kDaIGF-I interacts with IGFBP-2.BIND10407151 
-HPRD,BioGRID11063745 
IGFBP3BP-53 | IBP3insulin-like growth factor binding protein 3-HPRD,BioGRID11600567 
IGF-I interacts with IGFBP-3.BIND10407151 
IGFBP4BP-4 | HT29-IGFBP | IBP4 | IGFBP-4insulin-like growth factor binding protein 4-HPRD,BioGRID9722589 
IGF-I interacts with IGFBP-4.BIND10407151 
IGFBP5IBP5insulin-like growth factor binding protein 5IGF-I interacts with IGFBP-5.BIND10407151 
-HPRD,BioGRID9497324 
IGFBP6IBP6insulin-like growth factor binding protein 6IGF-I interacts with IGFBP-6.BIND10407151 
-HPRD7683646 
IGFBP7FSTL2 | IGFBP-7 | IGFBP-7v | IGFBPRP1 | MAC25 | PSFinsulin-like growth factor binding protein 7-HPRD,BioGRID8939990 
IGSF1IGCD1 | IGDC1 | INHBP | KIAA0364 | MGC75490 | PGSF2immunoglobulin superfamily, member 1-HPRD,BioGRID11344214 
NOVCCN3 | IGFBP9nephroblastoma overexpressed gene-HPRD,BioGRID10084601 
TFDKFZp781D0156 | PRO1557 | PRO2086transferrinReconstituted ComplexBioGRID11749962 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_OOCYTE_MEIOSIS 11479All SZGR genes in this pathway
KEGG_P53_SIGNALING_PATHWAY 6945All SZGR genes in this pathway
KEGG_MTOR_SIGNALING_PATHWAY 5240All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_LONG_TERM_DEPRESSION 7053All SZGR genes in this pathway
KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 8659All SZGR genes in this pathway
KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 4229All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_GLIOMA 6556All SZGR genes in this pathway
KEGG_PROSTATE_CANCER 8975All SZGR genes in this pathway
KEGG_MELANOMA 7157All SZGR genes in this pathway
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 8565All SZGR genes in this pathway
KEGG_DILATED_CARDIOMYOPATHY 9268All SZGR genes in this pathway
BIOCARTA_HDAC_PATHWAY 3225All SZGR genes in this pathway
BIOCARTA_ERYTH_PATHWAY 1511All SZGR genes in this pathway
BIOCARTA_IGF1_PATHWAY 2116All SZGR genes in this pathway
BIOCARTA_NFAT_PATHWAY 5645All SZGR genes in this pathway
BIOCARTA_BAD_PATHWAY 2623All SZGR genes in this pathway
BIOCARTA_IGF1MTOR_PATHWAY 2014All SZGR genes in this pathway
BIOCARTA_LONGEVITY_PATHWAY 1513All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 6754All SZGR genes in this pathway
PID_ER_NONGENOMIC_PATHWAY 4135All SZGR genes in this pathway
PID_SHP2_PATHWAY 5846All SZGR genes in this pathway
PID_IGF1_PATHWAY 3023All SZGR genes in this pathway
PID_CERAMIDE_PATHWAY 4837All SZGR genes in this pathway
PID_AVB3_INTEGRIN_PATHWAY 7553All SZGR genes in this pathway
PID_ECADHERIN_STABILIZATION_PATHWAY 4234All SZGR genes in this pathway
TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_DUCTAL_NORMAL_UP 6938All SZGR genes in this pathway
CORRE_MULTIPLE_MYELOMA_DN 6241All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN 291176All SZGR genes in this pathway
PACHER_TARGETS_OF_IGF1_AND_IGF2_UP 3527All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP 238135All SZGR genes in this pathway
BARRIER_CANCER_RELAPSE_NORMAL_SAMPLE_UP 3221All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
BUSA_SAM68_TARGETS_DN 65All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_UP 3024All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4 261153All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_2FC_DN 2113All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
GALIE_TUMOR_ANGIOGENESIS 87All SZGR genes in this pathway
BERTUCCI_INVASIVE_CARCINOMA_DUCTAL_VS_LOBULAR_DN 4634All SZGR genes in this pathway
GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN 176104All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
SCHAEFFER_SOX9_TARGETS_IN_PROSTATE_DEVELOPMENT_DN 4533All SZGR genes in this pathway
RICKMAN_HEAD_AND_NECK_CANCER_F 5432All SZGR genes in this pathway
KAUFFMANN_DNA_REPLICATION_GENES 14787All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_TGFA_DN 6544All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_E2F1_DN 6438All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_DN 6340All SZGR genes in this pathway
LEE_LIVER_CANCER_E2F1_DN 6442All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
GUO_HEX_TARGETS_DN 6536All SZGR genes in this pathway
IGLESIAS_E2F_TARGETS_DN 1611All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
LIU_SMARCA4_TARGETS 6439All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_0HR 6348All SZGR genes in this pathway
TSENG_IRS1_TARGETS_UP 11371All SZGR genes in this pathway
BACOLOD_RESISTANCE_TO_ALKYLATING_AGENTS_UP 2617All SZGR genes in this pathway
GERHOLD_ADIPOGENESIS_UP 4940All SZGR genes in this pathway
WENG_POR_TARGETS_LIVER_DN 2011All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_4NQO_OR_UV 6344All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_UP 170107All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP 439257All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_LUNG_DN 3722All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_A_UP 8452All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_DN 10868All SZGR genes in this pathway
MATZUK_EARLY_ANTRAL_FOLLICLE 1311All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_DN 3125All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
WU_SILENCED_BY_METHYLATION_IN_BLADDER_CANCER 5542All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
LIU_VAV3_PROSTATE_CARCINOGENESIS_UP 8961All SZGR genes in this pathway
ZHAN_LATE_DIFFERENTIATION_GENES_UP 3324All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SURVIVAL_DN 11376All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_UP 4738All SZGR genes in this pathway
MIKKELSEN_MCV6_ICP_WITH_H3K4ME3_AND_H3K27ME3 3421All SZGR genes in this pathway
NAKAYAMA_FGF2_TARGETS 2917All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_DN 267160All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_DN 210141All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA2_DN 8051All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3_AND_H3K27ME3 13785All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_11 10368All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP 397206All SZGR genes in this pathway
TERAO_AOX4_TARGETS_SKIN_DN 2715All SZGR genes in this pathway
IKEDA_MIR1_TARGETS_UP 5339All SZGR genes in this pathway
KATSANOU_ELAVL1_TARGETS_UP 169105All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_DN 157105All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_DN 244157All SZGR genes in this pathway
DURAND_STROMA_S_UP 297194All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/2061511581A,m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-142-5p442144281A,m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-150359035971A,m8hsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-18181187m8hsa-miR-18aUAAGGUGCAUCUAGUGCAGAUA
hsa-miR-18bUAAGGUGCAUCUAGUGCAGUUA
miR-186367636821Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-19178184m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-2636893695m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-27437643821Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-29366436711A,m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-30-3p327832841Ahsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-3206406461Ahsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-409-3p150156m8hsa-miR-409-3pCGAAUGUUGCUCGGUGAACCCCU
miR-4868558611Ahsa-miR-486UCCUGUACUGAGCUGCCCCGAG
miR-4959169231A,m8hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-4968328381Ahsa-miR-496AUUACAUGGCCAAUCUC
hsa-miR-496AUUACAUGGCCAAUCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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