Gene Page: KRT82
Summary ?
| GeneID | 3888 |
| Symbol | KRT82 |
| Synonyms | HB2|Hb-2|KRTHB2 |
| Description | keratin 82 |
| Reference | MIM:601078|HGNC:HGNC:6459|Ensembl:ENSG00000161850|HPRD:03048|Vega:OTTHUMG00000169636 |
| Gene type | protein-coding |
| Map location | 12q13 |
| Pascal p-value | 0.195 |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| KRT82 | chr12 | 52799985 | C | T | NM_033033 | p.26R>Q | missense | Schizophrenia | DNM:Fromer_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| LRP10 | 0.86 | 0.86 |
| CTDSP1 | 0.85 | 0.83 |
| SLC12A4 | 0.85 | 0.90 |
| PBXIP1 | 0.84 | 0.83 |
| MLC1 | 0.83 | 0.81 |
| FGFRL1 | 0.82 | 0.82 |
| SYDE1 | 0.82 | 0.83 |
| SLC9A3R1 | 0.81 | 0.77 |
| ITGA7 | 0.80 | 0.83 |
| AXL | 0.80 | 0.84 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| COQ3 | -0.59 | -0.61 |
| C20orf7 | -0.58 | -0.60 |
| FAM92A1 | -0.58 | -0.61 |
| NDUFAF2 | -0.56 | -0.64 |
| COMMD3 | -0.56 | -0.63 |
| OXSM | -0.55 | -0.62 |
| C18orf21 | -0.55 | -0.58 |
| RWDD2A | -0.55 | -0.55 |
| VPS29 | -0.54 | -0.57 |
| ZNF32 | -0.54 | -0.62 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| FIGUEROA AML METHYLATION CLUSTER 5 DN | 50 | 31 | All SZGR 2.0 genes in this pathway |