Gene Page: LIMS1

Summary
GeneID  3987
Symbol  LIMS1
Synonyms  PINCH|PINCH1
Description  LIM and senescent cell antigen-like domains 1
See related  HGNC:6616|MIM:602567|Ensembl:ENSG00000169756|HPRD:03978|
Locus tag  -
Gene type  protein-coding
Map location  2q12.3-q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0004 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00755 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ARFGEF20.920.92
DPP80.910.92
ZFP1060.910.91
DMXL10.910.91
ADAM220.900.92
VPS13D0.900.91
ROCK20.900.89
EEA10.890.88
CPD0.890.86
ATG2B0.890.89
Top 10 negatively co-expressed genes
AC006276.2-0.42-0.43
C1orf61-0.41-0.58
NUDT8-0.40-0.45
RPL35-0.40-0.47
DBI-0.39-0.49
PFDN5-0.39-0.40
RHOC-0.38-0.48
ST20-0.38-0.43
RPL36-0.38-0.43
TBC1D10A-0.38-0.31
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007569cell agingTAS7517666 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACP6ACPL1 | LPAP | PACPL1acid phosphatase 6, lysophosphatidicAffinity Capture-MSBioGRID17353931 
EHMT2BAT8 | C6orf30 | DKFZp686H08213 | FLJ35547 | G9A | KMT1C | NG36 | NG36/G9aeuchromatic histone-lysine N-methyltransferase 2Two-hybridBioGRID16189514 
ILKDKFZp686F1765 | P59integrin-linked kinasePINCH interacts with ILK.BIND15565145 
-HPRD,BioGRID10022929 
LPXNLDPLleupaxinTwo-hybridBioGRID16189514 
NCK2GRB4 | NCKbetaNCK adaptor protein 2Nck-2 interacts with PINCHBIND9843575 
-HPRD,BioGRID9843575 
PARVAFLJ10793 | FLJ12254 | MXRA2parvin, alpha-HPRD12432066 
RBBP8CTIP | RIMretinoblastoma binding protein 8Two-hybridBioGRID16189514 
TMSB4XFX | PTMB4 | TB4X | TMSB4thymosin beta 4, X-linkedPINCH interacts with Thymosin Beta-4.BIND15565145 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_ILK_PATHWAY 4532All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION 12077All SZGR genes in this pathway
REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS 1410All SZGR genes in this pathway
REACTOME_CELL_JUNCTION_ORGANIZATION 7843All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_UP 285181All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP 408247All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP 276165All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_UP 13983All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP 204140All SZGR genes in this pathway
PASTURAL_RIZ1_TARGETS_UP 115All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_DN 229142All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
SILIGAN_TARGETS_OF_EWS_FLI1_FUSION_UP 1512All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
SAKAI_TUMOR_INFILTRATING_MONOCYTES_UP 2719All SZGR genes in this pathway
MORI_IMMATURE_B_LYMPHOCYTE_UP 5335All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
MANALO_HYPOXIA_UP 207145All SZGR genes in this pathway
ABBUD_LIF_SIGNALING_1_DN 2617All SZGR genes in this pathway
IGLESIAS_E2F_TARGETS_UP 151103All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_MATURE_CELL 293160All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP 198132All SZGR genes in this pathway
BURTON_ADIPOGENESIS_11 5740All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
SANSOM_APC_MYC_TARGETS 217138All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_4NQO_OR_GAMMA_RADIATION 1513All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_UP 12589All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_DN 185116All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway


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