Gene Page: LRP3
Summary ?
| GeneID | 4037 |
| Symbol | LRP3 |
| Synonyms | - |
| Description | LDL receptor related protein 3 |
| Reference | MIM:603159|HGNC:HGNC:6695|Ensembl:ENSG00000130881|HPRD:04406|Vega:OTTHUMG00000180343 |
| Gene type | protein-coding |
| Map location | 19q13.11 |
| Pascal p-value | 0.025 |
| Sherlock p-value | 0.915 |
| eGene | Myers' cis & trans Meta |
| Support | CompositeSet Darnell FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs2376734 | chr9 | 77976699 | LRP3 | 4037 | 0.18 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| LIN7B | 0.83 | 0.84 |
| TM7SF2 | 0.80 | 0.80 |
| SCO2 | 0.79 | 0.79 |
| AC019171.2 | 0.78 | 0.79 |
| NUDT14 | 0.78 | 0.78 |
| MIF | 0.77 | 0.75 |
| COMMD5 | 0.77 | 0.77 |
| CUTA | 0.77 | 0.76 |
| MESP1 | 0.77 | 0.82 |
| MAP1LC3A | 0.77 | 0.78 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.26 | -0.47 | -0.43 |
| AF347015.18 | -0.46 | -0.41 |
| AF347015.2 | -0.45 | -0.38 |
| AF347015.8 | -0.44 | -0.38 |
| MT-CO2 | -0.42 | -0.35 |
| AF347015.33 | -0.42 | -0.38 |
| MT-CYB | -0.42 | -0.38 |
| AF347015.15 | -0.42 | -0.36 |
| MT-ATP8 | -0.42 | -0.39 |
| KIF1C | -0.40 | -0.36 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| CHARAFE BREAST CANCER LUMINAL VS BASAL UP | 380 | 215 | All SZGR 2.0 genes in this pathway |
| TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D DN | 143 | 83 | All SZGR 2.0 genes in this pathway |
| TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP | 157 | 104 | All SZGR 2.0 genes in this pathway |
| BENPORATH NANOG TARGETS | 988 | 594 | All SZGR 2.0 genes in this pathway |
| PENG GLUCOSE DEPRIVATION DN | 169 | 112 | All SZGR 2.0 genes in this pathway |
| VERHAAK AML WITH NPM1 MUTATED DN | 246 | 180 | All SZGR 2.0 genes in this pathway |
| URS ADIPOCYTE DIFFERENTIATION DN | 30 | 20 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | 911 | 527 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | All SZGR 2.0 genes in this pathway |
| RIZKI TUMOR INVASIVENESS 2D UP | 69 | 46 | All SZGR 2.0 genes in this pathway |
| BHATI G2M ARREST BY 2METHOXYESTRADIOL UP | 125 | 68 | All SZGR 2.0 genes in this pathway |
| NAKAMURA ADIPOGENESIS EARLY DN | 38 | 27 | All SZGR 2.0 genes in this pathway |
| NAKAMURA ADIPOGENESIS LATE DN | 38 | 25 | All SZGR 2.0 genes in this pathway |