Gene Page: ARRB1

Summary
GeneID  408
Symbol  ARRB1
Synonyms  ARB1|ARR1
Description  arrestin, beta 1
See related  HGNC:711|MIM:107940|Ensembl:ENSG00000137486|HPRD:00146|
Locus tag  -
Gene type  protein-coding
Map location  11q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0119 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SLC16A20.920.93
PTPN90.910.94
TGFBRAP10.910.93
PUM10.900.92
SARM10.900.92
TRIO0.900.93
TBC1D140.900.94
ZCCHC140.900.94
ZMYM30.900.92
FOXJ20.900.93
Top 10 negatively co-expressed genes
AF347015.31-0.76-0.84
MT-CO2-0.75-0.85
AF347015.27-0.72-0.81
FXYD1-0.72-0.80
AF347015.33-0.72-0.79
C5orf53-0.71-0.74
MT-CYB-0.71-0.80
AF347015.8-0.71-0.82
S100B-0.71-0.78
HIGD1B-0.70-0.82
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI17353931 |17620599 
GO:0004857enzyme inhibitor activityTAS2163110 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionTAS9924018 
GO:0007600sensory perceptionIEA-
GO:0050896response to stimulusIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005834heterotrimeric G-protein complexTAS10823817 
GO:0005624membrane fractionIDA10823817 
GO:0005625soluble fractionTAS9924018 
GO:0005737cytoplasmIDA10823817 
GO:0005886plasma membraneTAS9924018 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADRB1ADRB1R | B1AR | BETA1AR | RHRadrenergic, beta-1-, receptor-HPRD,BioGRID10862778 
ADRBK1BARK1 | BETA-ARK1 | FLJ16718 | GRK2adrenergic, beta, receptor kinase 1-HPRD8885248 
AP2B1ADTB2 | AP105B | AP2-BETA | CLAPB1 | DKFZp781K0743adaptor-related protein complex 2, beta 1 subunit-HPRD11777907 
AP3B1ADTB3 | ADTB3A | HPS | HPS2 | PEadaptor-related protein complex 3, beta 1 subunitAffinity Capture-MSBioGRID17353931 
ARF6DKFZp564M0264ADP-ribosylation factor 6-HPRD,BioGRID11533043 |11867621 
ARR3ARRXarrestin 3, retinal (X-arrestin)Affinity Capture-MSBioGRID17353931 
ARRB2ARB2 | ARR2 | BARR2 | DKFZp686L0365arrestin, beta 2Affinity Capture-MSBioGRID17353931 
BOP1KIAA0124block of proliferation 1Affinity Capture-MSBioGRID17353931 
CCL14CC-1 | CC-3 | CKb1 | HCC-1 | HCC-3 | MCIF | NCC-2 | NCC2 | SCYA14 | SCYL2 | SY14chemokine (C-C motif) ligand 14Affinity Capture-MSBioGRID17353931 
CCR2CC-CKR-2 | CCR2A | CCR2B | CD192 | CKR2 | CKR2A | CKR2B | CMKBR2 | MCP-1-Rchemokine (C-C motif) receptor 2-HPRD9501202 
CCR5CC-CKR-5 | CCCKR5 | CD195 | CKR-5 | CKR5 | CMKBR5chemokine (C-C motif) receptor 5-HPRD,BioGRID12065593 
CHD1DKFZp686E2337chromodomain helicase DNA binding protein 1Affinity Capture-MSBioGRID17353931 
CLTCCHC | CHC17 | CLH-17 | CLTCL2 | Hc | KIAA0034clathrin, heavy chain (Hc)-HPRD9827808 
CMBLFLJ23617carboxymethylenebutenolidase homolog (Pseudomonas)Affinity Capture-MSBioGRID17353931 
CSKMGC117393c-src tyrosine kinase-HPRD,BioGRID10753943 
CSNK2A1CK2A1 | CKIIcasein kinase 2, alpha 1 polypeptideAffinity Capture-MSBioGRID17353931 
CYTH2ARNO | CTS18 | CTS18.1 | PSCD2 | PSCD2L | SEC7L | Sec7p-L | Sec7p-likecytohesin 2-HPRD,BioGRID11533043 
DDX27DKFZp667N057 | FLJ12917 | FLJ20596 | FLJ22238 | HSPC259 | MGC1018 | MGC163147 | PP3241 | RHLP | Rrp3p | dJ686N3.1DEAD (Asp-Glu-Ala-Asp) box polypeptide 27Affinity Capture-MSBioGRID17353931 
DVL1DVL | MGC54245dishevelled, dsh homolog 1 (Drosophila)-HPRD,BioGRID11742073 
DVL2-dishevelled, dsh homolog 2 (Drosophila)-HPRD,BioGRID11742073 
FGRFLJ43153 | MGC75096 | SRC2 | c-fgr | c-src2 | p55c-fgr | p58c-fgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog-HPRD10973280 
GNMT-glycine N-methyltransferaseTwo-hybridBioGRID16189514 
GNRHRGNRHR1 | GRHR | LHRHR | LRHRgonadotropin-releasing hormone receptor-HPRD11278883 
HDGF2MGC2641hepatoma-derived growth factor-related protein 2Affinity Capture-MSBioGRID17353931 
IL8RBCD182 | CDw128b | CMKAR2 | CXCR2 | IL8R2 | IL8RAinterleukin 8 receptor, beta-HPRD,BioGRID11170396 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)Affinity Capture-MSBioGRID17353931 
KHK-ketohexokinase (fructokinase)Affinity Capture-MSBioGRID17353931 
KPNA3IPOA4 | SRP1gamma | SRP4 | hSRP1karyopherin alpha 3 (importin alpha 4)Affinity Capture-MSBioGRID17353931 
MAPK10FLJ12099 | FLJ33785 | JNK3 | JNK3A | MGC50974 | PRKM10 | p493F12 | p54bSAPKmitogen-activated protein kinase 10Affinity Capture-WesternBioGRID11356842 
MDM2HDMX | MGC71221 | hdm2Mdm2 p53 binding protein homolog (mouse)Affinity Capture-WesternBioGRID12538596 
NFKBIAIKBA | MAD-3 | NFKBInuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaBeta-Arr1 interacts with I-kappa-B-alpha to prevent the phosphorylation and degradation of I-kappa-B-alpha.BIND15125834 
NOLC1KIAA0035 | NOPP130 | NOPP140 | NS5ATP13 | P130nucleolar and coiled-body phosphoprotein 1Affinity Capture-MSBioGRID17353931 
NSFSKD2N-ethylmaleimide-sensitive factor-HPRD,BioGRID10196135 
OPRD1OPRDopioid receptor, delta 1-HPRD,BioGRID11259507 
PDE4DDPDE3 | HSPDE4D | PDE4DN2 | STRK1phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)The amino-terminus of PDE4D5 interacts with Beta-Arrestin 1.BIND14500724 
PES1PESpescadillo homolog 1, containing BRCT domain (zebrafish)Affinity Capture-MSBioGRID17353931 
PTH1RMGC138426 | MGC138452 | PTHR | PTHR1parathyroid hormone 1 receptor-HPRD12220636 
PTHLHHHM | MGC14611 | PLP | PTHR | PTHRPparathyroid hormone-like hormone-HPRD,BioGRID12220636 
RALGDSFLJ20922 | RGF | RalGEFral guanine nucleotide dissociation stimulator-HPRD,BioGRID12105416 
RPL7L1MGC62004 | dJ475N16.4ribosomal protein L7-like 1Affinity Capture-MSBioGRID17353931 
RTF1CDG1N | GTL7 | KIAA0252Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)Affinity Capture-MSBioGRID17353931 
SLC9A5NHE5solute carrier family 9 (sodium/hydrogen exchanger), member 5An unspecified isoform of Beta-Arr1 interacts with NHE5.BIND15699339 
TCOF1MFD1 | treacleTreacher Collins-Franceschetti syndrome 1Affinity Capture-MSBioGRID17353931 
TRHRMGC141920thyrotropin-releasing hormone receptor-HPRD12393857 
ZBTB43ZBTB22B | ZNF-X | ZNF297Bzinc finger and BTB domain containing 43Two-hybridBioGRID16189514 
ZRANB2DKFZp686J1831 | DKFZp686N09117 | FLJ41119 | ZIS | ZIS1 | ZIS2 | ZNF265zinc finger, RAN-binding domain containing 2Affinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
BIOCARTA_AGPCR_PATHWAY 1312All SZGR genes in this pathway
BIOCARTA_BARR_MAPK_PATHWAY 1211All SZGR genes in this pathway
BIOCARTA_BARRESTIN_SRC_PATHWAY 1514All SZGR genes in this pathway
BIOCARTA_BARRESTIN_PATHWAY 108All SZGR genes in this pathway
PID_ARF6_PATHWAY 3527All SZGR genes in this pathway
PID_IL8_CXCR2_PATHWAY 3426All SZGR genes in this pathway
PID_CXCR3_PATHWAY 4334All SZGR genes in this pathway
PID_THROMBIN_PAR1_PATHWAY 4332All SZGR genes in this pathway
PID_IL8_CXCR1_PATHWAY 2819All SZGR genes in this pathway
REACTOME_MEMBRANE_TRAFFICKING 12974All SZGR genes in this pathway
REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING 6031All SZGR genes in this pathway
REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS 2718All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH1 7046All SZGR genes in this pathway
REACTOME_LYSOSOME_VESICLE_BIOGENESIS 2311All SZGR genes in this pathway
REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS 5327All SZGR genes in this pathway
REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS 3220All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH 10364All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
DAVICIONI_PAX_FOXO1_SIGNATURE_IN_ARMS_UP 5938All SZGR genes in this pathway
IGARASHI_ATF4_TARGETS_DN 9065All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
DAVICIONI_RHABDOMYOSARCOMA_PAX_FOXO1_FUSION_UP 6437All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_UP 380215All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_UP 184125All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_UP 306188All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_DN 384230All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_UP 456228All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_DN 186107All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
PEREZ_TP53_AND_TP63_TARGETS 205145All SZGR genes in this pathway
EBAUER_TARGETS_OF_PAX3_FOXO1_FUSION_DN 4831All SZGR genes in this pathway
SCHEIDEREIT_IKK_INTERACTING_PROTEINS 5845All SZGR genes in this pathway
YORDY_RECIPROCAL_REGULATION_BY_ETS1_AND_SP100_UP 2511All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
GROSS_ELK3_TARGETS_UP 2716All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_UP 209139All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_ONLY_DN 4430All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
AMIT_EGF_RESPONSE_120_HELA 6947All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_11Q12_Q14_AMPLICON 15893All SZGR genes in this pathway
NIKOLSKY_MUTATED_AND_AMPLIFIED_IN_BREAST_CANCER 9460All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5 482296All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
RUIZ_TNC_TARGETS_UP 153107All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
HOFFMANN_IMMATURE_TO_MATURE_B_LYMPHOCYTE_UP 4334All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4 196124All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
NIELSEN_GIST 9866All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_NEURAL 12985All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN 374217All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
LIU_IL13_MEMORY_MODEL_UP 1712All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
DURAND_STROMA_S_UP 297194All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-224294361A,m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-3791071131Ahsa-miR-379brainUGGUAGACUAUGGAACGUA
miR-4313803861Ahsa-miR-431UGUCUUGCAGGCCGUCAUGCA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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