SZGR2

Summary ?

GeneID	408
Symbol	ARRB1
Synonyms	ARB1\|ARR1
Description	arrestin, beta 1
Reference	MIM:107940\|HGNC:HGNC:711\|Ensembl:ENSG00000137486\|HPRD:00146\|Vega:OTTHUMG00000165444
Gene type	protein-coding
Map location	11q13
Pascal p-value	0.045
Fetal beta	-0.419
DMG	1 (# studies)
Support	CompositeSet Darnell FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0119

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg02449461	11	75061838	ARRB1	1.373E-4	0.271	0.031	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SLC16A2	0.92	0.93
PTPN9	0.91	0.94
TGFBRAP1	0.91	0.93
PUM1	0.90	0.92
SARM1	0.90	0.92
TRIO	0.90	0.93
TBC1D14	0.90	0.94
ZCCHC14	0.90	0.94
ZMYM3	0.90	0.92
FOXJ2	0.90	0.93

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.76	-0.84
MT-CO2	-0.75	-0.85
AF347015.27	-0.72	-0.81
FXYD1	-0.72	-0.80
AF347015.33	-0.72	-0.79
C5orf53	-0.71	-0.74
MT-CYB	-0.71	-0.80
AF347015.8	-0.71	-0.82
S100B	-0.71	-0.78
HIGD1B	-0.70	-0.82

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IPI		17353931 \|17620599
GO:0004857	enzyme inhibitor activity	TAS		2163110
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007165	signal transduction	TAS		9924018
GO:0007600	sensory perception	IEA		-
GO:0050896	response to stimulus	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005834	heterotrimeric G-protein complex	TAS		10823817
GO:0005624	membrane fraction	IDA		10823817
GO:0005625	soluble fraction	TAS		9924018
GO:0005737	cytoplasm	IDA		10823817
GO:0005886	plasma membrane	TAS		9924018

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ADRB1	ADRB1R \| B1AR \| BETA1AR \| RHR	adrenergic, beta-1-, receptor	-	HPRD,BioGRID	10862778
ADRBK1	BARK1 \| BETA-ARK1 \| FLJ16718 \| GRK2	adrenergic, beta, receptor kinase 1	-	HPRD	8885248
AP2B1	ADTB2 \| AP105B \| AP2-BETA \| CLAPB1 \| DKFZp781K0743	adaptor-related protein complex 2, beta 1 subunit	-	HPRD	11777907
AP3B1	ADTB3 \| ADTB3A \| HPS \| HPS2 \| PE	adaptor-related protein complex 3, beta 1 subunit	Affinity Capture-MS	BioGRID	17353931
ARF6	DKFZp564M0264	ADP-ribosylation factor 6	-	HPRD,BioGRID	11533043 \|11867621
ARR3	ARRX	arrestin 3, retinal (X-arrestin)	Affinity Capture-MS	BioGRID	17353931
ARRB2	ARB2 \| ARR2 \| BARR2 \| DKFZp686L0365	arrestin, beta 2	Affinity Capture-MS	BioGRID	17353931
BOP1	KIAA0124	block of proliferation 1	Affinity Capture-MS	BioGRID	17353931
CCL14	CC-1 \| CC-3 \| CKb1 \| HCC-1 \| HCC-3 \| MCIF \| NCC-2 \| NCC2 \| SCYA14 \| SCYL2 \| SY14	chemokine (C-C motif) ligand 14	Affinity Capture-MS	BioGRID	17353931
CCR2	CC-CKR-2 \| CCR2A \| CCR2B \| CD192 \| CKR2 \| CKR2A \| CKR2B \| CMKBR2 \| MCP-1-R	chemokine (C-C motif) receptor 2	-	HPRD	9501202
CCR5	CC-CKR-5 \| CCCKR5 \| CD195 \| CKR-5 \| CKR5 \| CMKBR5	chemokine (C-C motif) receptor 5	-	HPRD,BioGRID	12065593
CHD1	DKFZp686E2337	chromodomain helicase DNA binding protein 1	Affinity Capture-MS	BioGRID	17353931
CLTC	CHC \| CHC17 \| CLH-17 \| CLTCL2 \| Hc \| KIAA0034	clathrin, heavy chain (Hc)	-	HPRD	9827808
CMBL	FLJ23617	carboxymethylenebutenolidase homolog (Pseudomonas)	Affinity Capture-MS	BioGRID	17353931
CSK	MGC117393	c-src tyrosine kinase	-	HPRD,BioGRID	10753943
CSNK2A1	CK2A1 \| CKII	casein kinase 2, alpha 1 polypeptide	Affinity Capture-MS	BioGRID	17353931
CYTH2	ARNO \| CTS18 \| CTS18.1 \| PSCD2 \| PSCD2L \| SEC7L \| Sec7p-L \| Sec7p-like	cytohesin 2	-	HPRD,BioGRID	11533043
DDX27	DKFZp667N057 \| FLJ12917 \| FLJ20596 \| FLJ22238 \| HSPC259 \| MGC1018 \| MGC163147 \| PP3241 \| RHLP \| Rrp3p \| dJ686N3.1	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	Affinity Capture-MS	BioGRID	17353931
DVL1	DVL \| MGC54245	dishevelled, dsh homolog 1 (Drosophila)	-	HPRD,BioGRID	11742073
DVL2	-	dishevelled, dsh homolog 2 (Drosophila)	-	HPRD,BioGRID	11742073
FGR	FLJ43153 \| MGC75096 \| SRC2 \| c-fgr \| c-src2 \| p55c-fgr \| p58c-fgr	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	-	HPRD	10973280
GNMT	-	glycine N-methyltransferase	Two-hybrid	BioGRID	16189514
GNRHR	GNRHR1 \| GRHR \| LHRHR \| LRHR	gonadotropin-releasing hormone receptor	-	HPRD	11278883
HDGF2	MGC2641	hepatoma-derived growth factor-related protein 2	Affinity Capture-MS	BioGRID	17353931
IL8RB	CD182 \| CDw128b \| CMKAR2 \| CXCR2 \| IL8R2 \| IL8RA	interleukin 8 receptor, beta	-	HPRD,BioGRID	11170396
JAK1	JAK1A \| JAK1B \| JTK3	Janus kinase 1 (a protein tyrosine kinase)	Affinity Capture-MS	BioGRID	17353931
KHK	-	ketohexokinase (fructokinase)	Affinity Capture-MS	BioGRID	17353931
KPNA3	IPOA4 \| SRP1gamma \| SRP4 \| hSRP1	karyopherin alpha 3 (importin alpha 4)	Affinity Capture-MS	BioGRID	17353931
MAPK10	FLJ12099 \| FLJ33785 \| JNK3 \| JNK3A \| MGC50974 \| PRKM10 \| p493F12 \| p54bSAPK	mitogen-activated protein kinase 10	Affinity Capture-Western	BioGRID	11356842
MDM2	HDMX \| MGC71221 \| hdm2	Mdm2 p53 binding protein homolog (mouse)	Affinity Capture-Western	BioGRID	12538596
NFKBIA	IKBA \| MAD-3 \| NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	Beta-Arr1 interacts with I-kappa-B-alpha to prevent the phosphorylation and degradation of I-kappa-B-alpha.	BIND	15125834
NOLC1	KIAA0035 \| NOPP130 \| NOPP140 \| NS5ATP13 \| P130	nucleolar and coiled-body phosphoprotein 1	Affinity Capture-MS	BioGRID	17353931
NSF	SKD2	N-ethylmaleimide-sensitive factor	-	HPRD,BioGRID	10196135
OPRD1	OPRD	opioid receptor, delta 1	-	HPRD,BioGRID	11259507
PDE4D	DPDE3 \| HSPDE4D \| PDE4DN2 \| STRK1	phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)	The amino-terminus of PDE4D5 interacts with Beta-Arrestin 1.	BIND	14500724
PES1	PES	pescadillo homolog 1, containing BRCT domain (zebrafish)	Affinity Capture-MS	BioGRID	17353931
PTH1R	MGC138426 \| MGC138452 \| PTHR \| PTHR1	parathyroid hormone 1 receptor	-	HPRD	12220636
PTHLH	HHM \| MGC14611 \| PLP \| PTHR \| PTHRP	parathyroid hormone-like hormone	-	HPRD,BioGRID	12220636
RALGDS	FLJ20922 \| RGF \| RalGEF	ral guanine nucleotide dissociation stimulator	-	HPRD,BioGRID	12105416
RPL7L1	MGC62004 \| dJ475N16.4	ribosomal protein L7-like 1	Affinity Capture-MS	BioGRID	17353931
RTF1	CDG1N \| GTL7 \| KIAA0252	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931
SLC9A5	NHE5	solute carrier family 9 (sodium/hydrogen exchanger), member 5	An unspecified isoform of Beta-Arr1 interacts with NHE5.	BIND	15699339
TCOF1	MFD1 \| treacle	Treacher Collins-Franceschetti syndrome 1	Affinity Capture-MS	BioGRID	17353931
TRHR	MGC141920	thyrotropin-releasing hormone receptor	-	HPRD	12393857
ZBTB43	ZBTB22B \| ZNF-X \| ZNF297B	zinc finger and BTB domain containing 43	Two-hybrid	BioGRID	16189514
ZRANB2	DKFZp686J1831 \| DKFZp686N09117 \| FLJ41119 \| ZIS \| ZIS1 \| ZIS2 \| ZNF265	zinc finger, RAN-binding domain containing 2	Affinity Capture-MS	BioGRID	17353931

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY	190	128	All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS	183	132	All SZGR 2.0 genes in this pathway
BIOCARTA AGPCR PATHWAY	13	12	All SZGR 2.0 genes in this pathway
BIOCARTA BARR MAPK PATHWAY	12	11	All SZGR 2.0 genes in this pathway
BIOCARTA BARRESTIN SRC PATHWAY	15	14	All SZGR 2.0 genes in this pathway
BIOCARTA BARRESTIN PATHWAY	10	8	All SZGR 2.0 genes in this pathway
PID ARF6 PATHWAY	35	27	All SZGR 2.0 genes in this pathway
PID IL8 CXCR2 PATHWAY	34	26	All SZGR 2.0 genes in this pathway
PID CXCR3 PATHWAY	43	34	All SZGR 2.0 genes in this pathway
PID THROMBIN PAR1 PATHWAY	43	32	All SZGR 2.0 genes in this pathway
PID IL8 CXCR1 PATHWAY	28	19	All SZGR 2.0 genes in this pathway
REACTOME MEMBRANE TRAFFICKING	129	74	All SZGR 2.0 genes in this pathway
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING	60	31	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	27	18	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH1	70	46	All SZGR 2.0 genes in this pathway
REACTOME LYSOSOME VESICLE BIOGENESIS	23	11	All SZGR 2.0 genes in this pathway
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	53	27	All SZGR 2.0 genes in this pathway
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	32	20	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH	103	64	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP	567	375	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
DAVICIONI PAX FOXO1 SIGNATURE IN ARMS UP	59	38	All SZGR 2.0 genes in this pathway
IGARASHI ATF4 TARGETS DN	90	65	All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS UP	332	228	All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP	255	177	All SZGR 2.0 genes in this pathway
DAVICIONI RHABDOMYOSARCOMA PAX FOXO1 FUSION UP	64	37	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP	380	215	All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN UP	184	125	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP	306	188	All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS DN	384	230	All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP	456	228	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL DN	186	107	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN	800	473	All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS	1174	695	All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS	355	243	All SZGR 2.0 genes in this pathway
PEREZ TP53 AND TP63 TARGETS	205	145	All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION DN	48	31	All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS	58	45	All SZGR 2.0 genes in this pathway
YORDY RECIPROCAL REGULATION BY ETS1 AND SP100 UP	25	11	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
GROSS ELK3 TARGETS UP	27	16	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP	209	139	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 ONLY DN	44	30	All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN	411	249	All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 120 HELA	69	47	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 11Q12 Q14 AMPLICON	158	93	All SZGR 2.0 genes in this pathway
NIKOLSKY MUTATED AND AMPLIFIED IN BREAST CANCER	94	60	All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP	412	249	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP	953	554	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5	482	296	All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP	282	183	All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP	578	341	All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP	259	185	All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS UP	153	107	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN	435	289	All SZGR 2.0 genes in this pathway
HOFFMANN IMMATURE TO MATURE B LYMPHOCYTE UP	43	34	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A4	196	124	All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP	395	249	All SZGR 2.0 genes in this pathway
NIELSEN GIST	98	66	All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION	456	287	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA NEURAL	129	85	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT	567	365	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN	374	217	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP	430	288	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A	898	516	All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7	403	240	All SZGR 2.0 genes in this pathway
LIU IL13 MEMORY MODEL UP	17	12	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38	337	236	All SZGR 2.0 genes in this pathway
DURAND STROMA S UP	297	194	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-22	429	436	1A,m8	hsa-miR-22^brain	AAGCUGCCAGUUGAAGAACUGU
miR-379	107	113	1A	hsa-miR-379^brain	UGGUAGACUAUGGAACGUA
miR-431	380	386	1A	hsa-miR-431	UGUCUUGCAGGCCGUCAUGCA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: ARRB1