Gene Page: TRPM1
Summary ?
| GeneID | 4308 |
| Symbol | TRPM1 |
| Synonyms | CSNB1C|LTRPC1|MLSN1 |
| Description | transient receptor potential cation channel subfamily M member 1 |
| Reference | MIM:603576|HGNC:HGNC:7146|Ensembl:ENSG00000134160|HPRD:04656|Vega:OTTHUMG00000129267 |
| Gene type | protein-coding |
| Map location | 15q13.3 |
| Pascal p-value | 0.04 |
| eGene | Caudate basal ganglia Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Putamen basal ganglia |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CNV:YES | Copy number variation studies | Manual curation | |
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| TRPM1 | chr15 | 31327796 | T | A | NM_001252020 NM_001252024 NM_002420 | p.902I>F p.885I>F p.863I>F | missense missense missense | Schizophrenia | DNM:Fromer_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs11070808 | 15 | 31390533 | TRPM1 | ENSG00000134160.9 | 9.15446E-10 | 0 | 62943 | gtex_brain_putamen_basal |
| rs10851488 | 15 | 31392375 | TRPM1 | ENSG00000134160.9 | 3.11146E-9 | 0 | 61101 | gtex_brain_putamen_basal |
| rs10851489 | 15 | 31392436 | TRPM1 | ENSG00000134160.9 | 2.90923E-7 | 0 | 61040 | gtex_brain_putamen_basal |
| rs6493454 | 15 | 31393945 | TRPM1 | ENSG00000134160.9 | 8.61323E-10 | 0 | 59531 | gtex_brain_putamen_basal |
| rs3809579 | 15 | 31394322 | TRPM1 | ENSG00000134160.9 | 1.48303E-11 | 0 | 59154 | gtex_brain_putamen_basal |
| rs4779820 | 15 | 31394810 | TRPM1 | ENSG00000134160.9 | 2.64185E-10 | 0 | 58666 | gtex_brain_putamen_basal |
| rs7182946 | 15 | 31394868 | TRPM1 | ENSG00000134160.9 | 8.13879E-10 | 0 | 58608 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| HAMAI APOPTOSIS VIA TRAIL UP | 584 | 356 | All SZGR 2.0 genes in this pathway |
| SHETH LIVER CANCER VS TXNIP LOSS PAM1 | 229 | 137 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| SUZUKI RESPONSE TO TSA AND DECITABINE 1B | 23 | 14 | All SZGR 2.0 genes in this pathway |
| MCGOWAN RSP6 TARGETS UP | 18 | 12 | All SZGR 2.0 genes in this pathway |
| RIZKI TUMOR INVASIVENESS 3D DN | 270 | 181 | All SZGR 2.0 genes in this pathway |
| GRADE COLON VS RECTAL CANCER DN | 56 | 36 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES HCP WITH H3 UNMETHYLATED | 63 | 31 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3 UNMETHYLATED | 228 | 119 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |