Gene Page: MYL2
Summary ?
| GeneID | 4633 |
| Symbol | MYL2 |
| Synonyms | CMH10|MLC-2s/v|MLC2 |
| Description | myosin light chain 2 |
| Reference | MIM:160781|HGNC:HGNC:7583|Ensembl:ENSG00000111245|HPRD:01181|Vega:OTTHUMG00000169535 |
| Gene type | protein-coding |
| Map location | 12q24.11 |
| Pascal p-value | 0.128 |
| Fetal beta | 0.483 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| UPF2 | 0.90 | 0.91 |
| SBNO1 | 0.86 | 0.87 |
| ATP11B | 0.86 | 0.86 |
| C9orf102 | 0.86 | 0.86 |
| RANBP2 | 0.85 | 0.86 |
| TBL1XR1 | 0.85 | 0.85 |
| HOOK3 | 0.84 | 0.84 |
| TMF1 | 0.84 | 0.85 |
| MTDH | 0.84 | 0.86 |
| LIN54 | 0.84 | 0.86 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ENHO | -0.66 | -0.75 |
| CST3 | -0.63 | -0.68 |
| TLCD1 | -0.62 | -0.66 |
| S100A16 | -0.61 | -0.66 |
| METRN | -0.60 | -0.66 |
| HIGD1B | -0.60 | -0.66 |
| AF347015.31 | -0.60 | -0.66 |
| RHOC | -0.60 | -0.68 |
| FXYD1 | -0.60 | -0.64 |
| RAMP1 | -0.59 | -0.65 |