Gene Page: ATF4

Summary ?
GeneID468
SymbolATF4
SynonymsCREB-2|CREB2|TAXREB67|TXREB
Descriptionactivating transcription factor 4
ReferenceMIM:604064|HGNC:HGNC:786|Ensembl:ENSG00000128272|HPRD:06817|Vega:OTTHUMG00000151099
Gene typeprotein-coding
Map location22q13.1
Pascal p-value3.056E-7
Sherlock p-value0.068
Fetal beta1.693
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6001609chr2239892858ATF44680.06cis
rs11891594chr2195857382ATF44680.08trans
rs6954503chr745155967ATF44680.19trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SND10.870.84
RPN10.870.86
PSMD20.870.84
C22orf280.870.86
DAP30.870.85
CCT70.860.84
PRMT50.860.82
MTCH20.860.86
ZNF2070.860.84
FAF10.860.85
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.74-0.71
AF347015.8-0.73-0.72
AF347015.21-0.73-0.72
AF347015.31-0.72-0.71
AF347015.2-0.71-0.73
AF347015.33-0.70-0.71
AF347015.27-0.69-0.70
MT-CYB-0.69-0.69
AF347015.15-0.68-0.70
AF347015.26-0.68-0.69

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityTAS12689582 
GO:0003704specific RNA polymerase II transcription factor activityISS-
GO:0016563transcription activator activityIMP11960987 
GO:0016563transcription activator activityISS-
GO:0016563transcription activator activityNAS9190894 
GO:0043565sequence-specific DNA bindingIEA-
GO:0046983protein dimerization activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentISS-
GO:0006350transcriptionIEA-
GO:0006520amino acid metabolic processTAS12689582 
GO:0006094gluconeogenesisISS-
GO:0006950response to stressIEP15314157 
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMP15788408 
GO:0045944positive regulation of transcription from RNA polymerase II promoterISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusISS-
GO:0005737cytoplasmISS-
GO:0005886plasma membraneIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CCDC106HSU79303 | ZNF581coiled-coil domain containing 106Two-hybridBioGRID16169070 
CEBPBC/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5CCAAT/enhancer binding protein (C/EBP), beta-HPRD11018027 
CEBPGGPE1BP | IG/EBP-1CCAAT/enhancer binding protein (C/EBP), gamma-HPRD,BioGRID1371974 
CREBBPCBP | KAT3A | RSTSCREB binding proteinReconstituted ComplexBioGRID9295363 
DAPK3FLJ36473 | ZIP | ZIPKdeath-associated protein kinase 3-HPRD9488481 
DISC1C1orf136 | FLJ13381 | FLJ21640 | FLJ25311 | FLJ41105 | KIAA0457 | SCZD9disrupted in schizophrenia 1-HPRD,BioGRID12812986 
DISC1C1orf136 | FLJ13381 | FLJ21640 | FLJ25311 | FLJ41105 | KIAA0457 | SCZD9disrupted in schizophrenia 1An unspecified isoform of DISC1 interacts with ATF4.BIND14623284 
DISC1C1orf136 | FLJ13381 | FLJ21640 | FLJ25311 | FLJ41105 | KIAA0457 | SCZD9disrupted in schizophrenia 1DISC-1 interacts with ATF4.BIND12812986 
EIF2ACDA02 | EIF-2A | MST089 | MSTP004 | MSTP089eukaryotic translation initiation factor 2A, 65kDaAffinity Capture-WesternBioGRID15475356 
GABBR2FLJ36928 | GABABR2 | GPR51 | GPRC3B | HG20 | HRIHFB2099gamma-aminobutyric acid (GABA) B receptor, 2-HPRD,BioGRID11087824 
GPS2AMF-1 | MGC104294 | MGC119287 | MGC119288 | MGC119289G protein pathway suppressor 2Two-hybridBioGRID16189514 
GTF2BTF2B | TFIIBgeneral transcription factor IIBReconstituted ComplexBioGRID9295363 
GTF2F2BTF4 | RAP30 | TF2F2 | TFIIFgeneral transcription factor IIF, polypeptide 2, 30kDa-HPRD,BioGRID9295363 
JUNAP-1 | AP1 | c-Junjun oncogene-HPRD,BioGRID1827203 
LDOC1BCUR1 | Mar7 | Mart7leucine zipper, down-regulated in cancer 1Two-hybridBioGRID16189514 
NFE2L1FLJ00380 | LCR-F1 | NRF1 | TCF11nuclear factor (erythroid-derived 2)-like 1-HPRD11025215 
NFE2L2NRF2nuclear factor (erythroid-derived 2)-like 2-HPRD11274184 
POLR2CRPB3 | RPB31 | hRPB33 | hsRPB3polymerase (RNA) II (DNA directed) polypeptide C, 33kDa-HPRD,BioGRID12860379 
PTCD3DKFZp666K071 | FLJ20758Pentatricopeptide repeat domain 3Two-hybridBioGRID16189514 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding proteinReconstituted ComplexBioGRID9295363 
TREX2-three prime repair exonuclease 2Two-hybridBioGRID16189514 
TRIB3C20orf97 | NIPK | SINK | SKIP3 | TRB3tribbles homolog 3 (Drosophila)-HPRD,BioGRID12743605 
TRIB3C20orf97 | NIPK | SINK | SKIP3 | TRB3tribbles homolog 3 (Drosophila)SKIP3 interacts with ATF4.BIND12743605 
TTRHsT2651 | PALB | TBPAtransthyretinTwo-hybridBioGRID16189514 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG MAPK SIGNALING PATHWAY 267205All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION 7057All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126103All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 10177All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER 8975All SZGR 2.0 genes in this pathway
PID FRA PATHWAY 3728All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 13391All SZGR 2.0 genes in this pathway
REACTOME PERK REGULATED GENE EXPRESSION 2914All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA 139All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF GENES BY ATF4 2612All SZGR 2.0 genes in this pathway
REACTOME UNFOLDED PROTEIN RESPONSE 8051All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA 118All SZGR 2.0 genes in this pathway
IGARASHI ATF4 TARGETS DN 9065All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473314All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS RED UP 1713All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN 229142All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770415All SZGR 2.0 genes in this pathway
BARIS THYROID CANCER UP 239All SZGR 2.0 genes in this pathway
MARTIN INTERACT WITH HDAC 4431All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
HEIDENBLAD AMPLICON 8Q24 DN 4628All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM1 229137All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN 156106All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 ONLY UP 3318All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230156All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
BENPORATH ES CORE NINE CORRELATED 10068All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION UP 14293All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC 182116All SZGR 2.0 genes in this pathway
LEE AGING NEOCORTEX DN 8049All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C6 3927All SZGR 2.0 genes in this pathway
HU GENOTOXIC DAMAGE 24HR 3522All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244151All SZGR 2.0 genes in this pathway
ZHOU TNF SIGNALING 30MIN 5436All SZGR 2.0 genes in this pathway
MARIADASON RESPONSE TO CURCUMIN SULINDAC 5 2317All SZGR 2.0 genes in this pathway
VARELA ZMPSTE24 TARGETS UP 4030All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G2 3018All SZGR 2.0 genes in this pathway
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION DN 4938All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN 10567All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292189All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281179All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA E2 11865All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A DN 10868All SZGR 2.0 genes in this pathway
CHO NR4A1 TARGETS 3322All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL DN 12775All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN UP 14798All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP 245159All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS DN 210128All SZGR 2.0 genes in this pathway
BOHN PRIMARY IMMUNODEFICIENCY SYNDROM UP 4730All SZGR 2.0 genes in this pathway
ZAIDI OSTEOBLAST TRANSCRIPTION FACTORS 1412All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL UP 5132All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN 238145All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN MYELOMA VS MATURE B LYMPHOCYTE 10176All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN PLASMA CELL VS MATURE B LYMPHOCYTE 6751All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 12HR UP 2918All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 24HR UP 126All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 32HR UP 117All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 48HR UP 149All SZGR 2.0 genes in this pathway
BAE BRCA1 TARGETS UP 7547All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 1HR UP 3325All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279155All SZGR 2.0 genes in this pathway