Gene Page: NDUFC2
Summary ?
| GeneID | 4718 |
| Symbol | NDUFC2 |
| Synonyms | B14.5b|CI-B14.5b|HLC-1|NADHDH2 |
| Description | NADH:ubiquinone oxidoreductase subunit C2 |
| Reference | MIM:603845|HGNC:HGNC:7706|Ensembl:ENSG00000151366|HPRD:11960|Vega:OTTHUMG00000166614 |
| Gene type | protein-coding |
| Map location | 11q14.1 |
| Pascal p-value | 0.015 |
| Sherlock p-value | 0.18 |
| Fetal beta | -1.281 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg26748758 | 11 | 77792715 | NDUFC2 | 3.97E-4 | 0.171 | 0.044 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs2716734 | chr2 | 39947720 | NDUFC2 | 4718 | 0.01 | trans | ||
| rs2716736 | chr2 | 39947946 | NDUFC2 | 4718 | 0.01 | trans | ||
| snp_a-2169623 | 0 | NDUFC2 | 4718 | 0.08 | trans | |||
| rs1587434 | chr6 | 66615354 | NDUFC2 | 4718 | 0 | trans | ||
| rs10503771 | chr8 | 25304019 | NDUFC2 | 4718 | 0.19 | trans | ||
| rs2408301 | chr13 | 51808915 | NDUFC2 | 4718 | 0.16 | trans | ||
| rs16959803 | chr13 | 88488982 | NDUFC2 | 4718 | 0.18 | trans | ||
| rs1241940 | chr14 | 84008851 | NDUFC2 | 4718 | 0.07 | trans | ||
| rs349973 | chr17 | 50642288 | NDUFC2 | 4718 | 0.07 | trans | ||
| rs16952224 | chr17 | 50868923 | NDUFC2 | 4718 | 0.06 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| EPN3 | 0.83 | 0.64 |
| SCN1A | 0.83 | 0.83 |
| AGPAT9 | 0.81 | 0.77 |
| NEFM | 0.81 | 0.66 |
| HAPLN4 | 0.81 | 0.75 |
| HCN2 | 0.80 | 0.84 |
| RET | 0.80 | 0.75 |
| ESYT1 | 0.79 | 0.65 |
| MYH7B | 0.79 | 0.69 |
| SSTR3 | 0.78 | 0.81 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| WDR86 | -0.36 | -0.38 |
| C9orf46 | -0.34 | -0.56 |
| GTF3C6 | -0.33 | -0.48 |
| EXOSC8 | -0.33 | -0.48 |
| NR2C2AP | -0.33 | -0.31 |
| AC006276.2 | -0.32 | -0.44 |
| TBC1D10A | -0.32 | -0.27 |
| RPL36 | -0.32 | -0.55 |
| PLEKHO1 | -0.32 | -0.29 |
| C6orf48 | -0.32 | -0.40 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG OXIDATIVE PHOSPHORYLATION | 135 | 73 | All SZGR 2.0 genes in this pathway |
| KEGG ALZHEIMERS DISEASE | 169 | 110 | All SZGR 2.0 genes in this pathway |
| KEGG PARKINSONS DISEASE | 133 | 78 | All SZGR 2.0 genes in this pathway |
| KEGG HUNTINGTONS DISEASE | 185 | 109 | All SZGR 2.0 genes in this pathway |
| REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | 141 | 85 | All SZGR 2.0 genes in this pathway |
| REACTOME RESPIRATORY ELECTRON TRANSPORT | 79 | 44 | All SZGR 2.0 genes in this pathway |
| REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | 98 | 56 | All SZGR 2.0 genes in this pathway |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 11Q12 Q14 AMPLICON | 158 | 93 | All SZGR 2.0 genes in this pathway |
| MOOTHA VOXPHOS | 87 | 51 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
| WONG MITOCHONDRIA GENE MODULE | 217 | 122 | All SZGR 2.0 genes in this pathway |
| ZHANG BREAST CANCER PROGENITORS UP | 425 | 253 | All SZGR 2.0 genes in this pathway |
| WANG TUMOR INVASIVENESS UP | 374 | 247 | All SZGR 2.0 genes in this pathway |
| MOOTHA HUMAN MITODB 6 2002 | 429 | 260 | All SZGR 2.0 genes in this pathway |
| MOOTHA MITOCHONDRIA | 447 | 277 | All SZGR 2.0 genes in this pathway |
| ROME INSULIN TARGETS IN MUSCLE UP | 442 | 263 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D | 882 | 506 | All SZGR 2.0 genes in this pathway |