Gene Page: NOS1

Summary ?
GeneID4842
SymbolNOS1
SynonymsIHPS1|N-NOS|NC-NOS|NOS|bNOS|nNOS
Descriptionnitric oxide synthase 1
ReferenceMIM:163731|HGNC:HGNC:7872|Ensembl:ENSG00000089250|HPRD:01226|Vega:OTTHUMG00000137376
Gene typeprotein-coding
Map location12q24.22
Pascal p-value5.53E-6
Fetal beta-0.854
DMG1 (# studies)
eGeneCortex
Hippocampus
SupportG2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_PocklingtonH1
G2Cdb.humanNRC
G2Cdb.humanPSD
G2Cdb.humanPSP
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg2127340712117799447NOS13.537E-4-0.4280.042DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005506iron ion bindingIEA-
GO:0005516calmodulin bindingIEA-
GO:0004517nitric-oxide synthase activityIEA-
GO:0020037heme bindingIEA-
GO:0010181FMN bindingIEA-
GO:0009055electron carrier activityIEA-
GO:0016491oxidoreductase activityIEA-
GO:0034617tetrahydrobiopterin bindingNAS7488039 
GO:0034618arginine bindingTAS17029414 
GO:0046870cadmium ion bindingISS-
GO:0046872metal ion bindingIEA-
GO:0050660FAD bindingIEA-
GO:0050661NADP bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0042136neurotransmitter biosynthetic processTASneuron, axon, Synap, Neurotransmitter (GO term level: 9)7545544 
GO:0001666response to hypoxiaIEP16276418 
GO:0006527arginine catabolic processIC7545544 
GO:0010523negative regulation of calcium ion transport into cytosolTAS17568574 
GO:0009408response to heatIDA18048451 
GO:0007520myoblast fusionTAS7545544 
GO:0006809nitric oxide biosynthetic processIEA-
GO:0033555multicellular organismal response to stressIMP18391107 
GO:0045909positive regulation of vasodilationIDA18048451 
GO:0045909positive regulation of vasodilationIMP18391107 
GO:0055114oxidation reductionIEA-
GO:0055117regulation of cardiac muscle contractionTAS9892689 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042995cell projectionIEAaxon (GO term level: 4)-
GO:0001917photoreceptor inner segmentISS17027776 
GO:0005856cytoskeletonISS7545544 
GO:0005737cytoplasmTAS17892502 
GO:0048471perinuclear region of cytoplasmISS17027776 
GO:0042383sarcolemmaIDA7545544 
GO:0016529sarcoplasmic reticulumIDA9892689 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARG1-arginase, liver-HPRD11849441 
BDKRB2B2R | BK-2 | BK2 | BKR2 | BRB2 | DKFZp686O088bradykinin receptor B2-HPRD,BioGRID10681501 
CAV3LGMD1C | LQT9 | MGC126100 | MGC126101 | MGC126129 | VIP-21 | VIP21caveolin 3-HPRD9353265 
DLG2DKFZp781D1854 | DKFZp781E0954 | FLJ37266 | MGC131811 | PSD-93discs, large homolog 2, chapsyn-110 (Drosophila)-HPRD,BioGRID8625413 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD,BioGRID8625413 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1-HPRD8864115 
HMOX1HO-1 | HSP32 | bK286B10heme oxygenase (decycling) 1-HPRD,BioGRID11849436 
NOS1AP6330408P19Rik | CAPON | MGC138500nitric oxide synthase 1 (neuronal) adaptor protein-HPRD,BioGRID9459447 
NOSIPCGI-25nitric oxide synthase interacting protein-HPRD15548660 
PTPN6HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1protein tyrosine phosphatase, non-receptor type 6-HPRD,BioGRID11511520 
PTPRNFLJ16131 | IA-2 | IA-2/PTP | IA2 | ICA512 | R-PTP-Nprotein tyrosine phosphatase, receptor type, N-HPRD11043403 
PUM2FLJ36528 | KIAA0235 | MGC138251 | MGC138253 | PUMH2 | PUML2pumilio homolog 2 (Drosophila)Affinity Capture-WesternBioGRID12690449 
RASD1AGS1 | DEXRAS1 | MGC:26290RAS, dexamethasone-induced 1Reconstituted ComplexBioGRID11086993 
SNTA1SNT1 | TACIP1 | dJ1187J4.5syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)-HPRD11747091 
SNTA1SNT1 | TACIP1 | dJ1187J4.5syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)Reconstituted ComplexBioGRID9412493 
SYN1SYN1a | SYN1b | SYNIsynapsin IReconstituted ComplexBioGRID11867766 
ZDHHC23MGC42530 | NIDDzinc finger, DHHC-type containing 23Affinity Capture-Western
Reconstituted Complex		BioGRID15105416 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ARGININE AND PROLINE METABOLISM 5439All SZGR 2.0 genes in this pathway
KEGG CALCIUM SIGNALING PATHWAY 178134All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION 7053All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE 169110All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS 5343All SZGR 2.0 genes in this pathway
BIOCARTA NOS1 PATHWAY 2421All SZGR 2.0 genes in this pathway
REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 3315All SZGR 2.0 genes in this pathway
REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 2519All SZGR 2.0 genes in this pathway
REACTOME PLATELET HOMEOSTASIS 7849All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER C 11347All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT UP 165100All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
XU GH1 EXOGENOUS TARGETS UP 8550All SZGR 2.0 genes in this pathway
LIU SMARCA4 TARGETS 6439All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268157All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430288All SZGR 2.0 genes in this pathway
MATZUK EARLY ANTRAL FOLLICLE 1311All SZGR 2.0 genes in this pathway
CHO NR4A1 TARGETS 3322All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE 242168All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317177All SZGR 2.0 genes in this pathway
MIKKELSEN IPS HCP WITH H3 UNMETHYLATED 8050All SZGR 2.0 genes in this pathway
MIKKELSEN ES HCP WITH H3 UNMETHYLATED 6331All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3 UNMETHYLATED 228119All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE M G1 14895All SZGR 2.0 genes in this pathway