Gene Page: NOS1

Summary
GeneID  4842
Symbol  NOS1
Synonyms  IHPS1|NOS|nNOS
Description  nitric oxide synthase 1 (neuronal)
See related  HGNC:7872|MIM:163731|Ensembl:ENSG00000089250|HPRD:01226|
Locus tag  -
Gene type  protein-coding
Map location  12q24.2-q24.31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005506iron ion bindingIEA-
GO:0005516calmodulin bindingIEA-
GO:0004517nitric-oxide synthase activityIEA-
GO:0020037heme bindingIEA-
GO:0010181FMN bindingIEA-
GO:0009055electron carrier activityIEA-
GO:0016491oxidoreductase activityIEA-
GO:0034617tetrahydrobiopterin bindingNAS7488039 
GO:0034618arginine bindingTAS17029414 
GO:0046870cadmium ion bindingISS-
GO:0046872metal ion bindingIEA-
GO:0050660FAD bindingIEA-
GO:0050661NADP bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0042136neurotransmitter biosynthetic processTASneuron, axon, Synap, Neurotransmitter (GO term level: 9)7545544 
GO:0001666response to hypoxiaIEP16276418 
GO:0006527arginine catabolic processIC7545544 
GO:0010523negative regulation of calcium ion transport into cytosolTAS17568574 
GO:0009408response to heatIDA18048451 
GO:0007520myoblast fusionTAS7545544 
GO:0006809nitric oxide biosynthetic processIEA-
GO:0033555multicellular organismal response to stressIMP18391107 
GO:0045909positive regulation of vasodilationIDA18048451 
GO:0045909positive regulation of vasodilationIMP18391107 
GO:0055114oxidation reductionIEA-
GO:0055117regulation of cardiac muscle contractionTAS9892689 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042995cell projectionIEAaxon (GO term level: 4)-
GO:0001917photoreceptor inner segmentISS17027776 
GO:0005856cytoskeletonISS7545544 
GO:0005737cytoplasmTAS17892502 
GO:0048471perinuclear region of cytoplasmISS17027776 
GO:0042383sarcolemmaIDA7545544 
GO:0016529sarcoplasmic reticulumIDA9892689 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARG1-arginase, liver-HPRD11849441 
BDKRB2B2R | BK-2 | BK2 | BKR2 | BRB2 | DKFZp686O088bradykinin receptor B2-HPRD,BioGRID10681501 
CAV3LGMD1C | LQT9 | MGC126100 | MGC126101 | MGC126129 | VIP-21 | VIP21caveolin 3-HPRD9353265 
DLG2DKFZp781D1854 | DKFZp781E0954 | FLJ37266 | MGC131811 | PSD-93discs, large homolog 2, chapsyn-110 (Drosophila)-HPRD,BioGRID8625413 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD,BioGRID8625413 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1-HPRD8864115 
HMOX1HO-1 | HSP32 | bK286B10heme oxygenase (decycling) 1-HPRD,BioGRID11849436 
NOS1AP6330408P19Rik | CAPON | MGC138500nitric oxide synthase 1 (neuronal) adaptor protein-HPRD,BioGRID9459447 
NOSIPCGI-25nitric oxide synthase interacting protein-HPRD15548660 
PTPN6HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1protein tyrosine phosphatase, non-receptor type 6-HPRD,BioGRID11511520 
PTPRNFLJ16131 | IA-2 | IA-2/PTP | IA2 | ICA512 | R-PTP-Nprotein tyrosine phosphatase, receptor type, N-HPRD11043403 
PUM2FLJ36528 | KIAA0235 | MGC138251 | MGC138253 | PUMH2 | PUML2pumilio homolog 2 (Drosophila)Affinity Capture-WesternBioGRID12690449 
RASD1AGS1 | DEXRAS1 | MGC:26290RAS, dexamethasone-induced 1Reconstituted ComplexBioGRID11086993 
SNTA1SNT1 | TACIP1 | dJ1187J4.5syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)-HPRD11747091 
Reconstituted ComplexBioGRID9412493 
SYN1SYN1a | SYN1b | SYNIsynapsin IReconstituted ComplexBioGRID11867766 
ZDHHC23MGC42530 | NIDDzinc finger, DHHC-type containing 23Affinity Capture-Western
Reconstituted Complex		BioGRID15105416 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ARGININE_AND_PROLINE_METABOLISM 5439All SZGR genes in this pathway
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_LONG_TERM_DEPRESSION 7053All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 5343All SZGR genes in this pathway
BIOCARTA_NOS1_PATHWAY 2421All SZGR genes in this pathway
REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS 3315All SZGR genes in this pathway
REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE 2519All SZGR genes in this pathway
REACTOME_PLATELET_HOMEOSTASIS 7849All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
RICKMAN_HEAD_AND_NECK_CANCER_C 11347All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_UP 165100All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
XU_GH1_EXOGENOUS_TARGETS_UP 8550All SZGR genes in this pathway
LIU_SMARCA4_TARGETS 6439All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP 268157All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
MATZUK_EARLY_ANTRAL_FOLLICLE 1311All SZGR genes in this pathway
CHO_NR4A1_TARGETS 3322All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12 317177All SZGR genes in this pathway
MIKKELSEN_IPS_HCP_WITH_H3_UNMETHYLATED 8050All SZGR genes in this pathway
MIKKELSEN_ES_HCP_WITH_H3_UNMETHYLATED 6331All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED 228119All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_M_G1 14895All SZGR genes in this pathway


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