Gene Page: PAFAH1B1

Summary
GeneID  5048
Symbol  PAFAH1B1
Synonyms  LIS1|LIS2|MDCR|MDS|PAFAH
Description  platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa
See related  HGNC:8574|MIM:601545|Ensembl:ENSG00000007168|HPRD:03329|
Locus tag  -
Gene type  protein-coding
Map location  17p13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 8 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1894 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CDCA7L0.870.61
CDK20.860.48
GLI30.860.68
WEE10.850.35
HELLS0.850.25
MELK0.850.27
FANCI0.850.26
TEAD20.850.40
KIF230.850.19
CCNB20.850.28
Top 10 negatively co-expressed genes
ADAP1-0.34-0.28
FXYD7-0.33-0.25
P2RX5-0.32-0.31
KCNF1-0.32-0.36
PINK1-0.32-0.33
KAZALD1-0.32-0.24
RLTPR-0.32-0.26
ASPHD1-0.31-0.20
CKMT1A-0.31-0.29
SULT4A1-0.31-0.40
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008201heparin bindingISS8028668 
GO:0008017microtubule bindingIEA-
GO:0051219phosphoprotein bindingISS-
GO:0042803protein homodimerization activityIEA-
GO:0043274phospholipase bindingISS8028668 
GO:0034452dynactin bindingISS11056532 
GO:0045502dynein bindingIDA11889140 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007405neuroblast proliferationIEAneuron (GO term level: 8)-
GO:0001764neuron migrationIEAneuron (GO term level: 8)-
GO:0007268synaptic transmissionIEAneuron, Synap, Neurotransmitter (GO term level: 6)-
GO:0021540corpus callosum morphogenesisIMPneuron, axon (GO term level: 15)9063735 
GO:0048854brain morphogenesisIMPBrain (GO term level: 8)9063735 
GO:0008090retrograde axon cargo transportIEAaxon (GO term level: 9)-
GO:0021819layer formation in the cerebral cortexISSGlial (GO term level: 15)-
GO:0007399nervous system developmentIEAneurite (GO term level: 5)-
GO:0000132establishment of mitotic spindle orientationIMP11056532 
GO:0000226microtubule cytoskeleton organizationIEA-
GO:0001675acrosome formationIEA-
GO:0016042lipid catabolic processIEA-
GO:0007049cell cycleIEA-
GO:0007067mitosisIEA-
GO:0008344adult locomotory behaviorIEA-
GO:0007611learning or memoryIEA-
GO:0006810transportIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
GO:0030036actin cytoskeleton organizationISS10729324 
GO:0021987cerebral cortex developmentIEA-
GO:0050885neuromuscular process controlling balanceIEA-
GO:0021766hippocampus developmentIEA-
GO:0032319regulation of Rho GTPase activityISS10729324 
GO:0051301cell divisionIEA-
GO:0047496vesicle transport along microtubuleIEA-
GO:0046469platelet activating factor metabolic processISS8028668 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000235astral microtubuleIDA11940666 
GO:0000776kinetochoreIDA11056532 |11889140 |11940666 
GO:0005813centrosomeIEA-
GO:0005819spindleIEA-
GO:0005829cytosolISS8028668 
GO:0005874microtubuleIEA-
GO:0005875microtubule associated complexIDA11889140 
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0016020membraneIEA-
GO:0005938cell cortexIDA11940666 
GO:0048471perinuclear region of cytoplasmISS-
GO:0031513nonmotile primary ciliumISS-
GO:0031512motile primary ciliumIEA-
GO:0031252cell leading edgeIEA-
GO:0031965nuclear membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CLIP1CLIP | CLIP-170 | CLIP170 | CYLN1 | MGC131604 | RSNCAP-GLY domain containing linker protein 1-HPRD,BioGRID11940666 
CSNK2A1CK2A1 | CKIIcasein kinase 2, alpha 1 polypeptide-HPRD,BioGRID10491172 
DAB1-disabled homolog 1 (Drosophila)-HPRD14578885 
DCTN1DAP-150 | DP-150 | HMN7B | P135dynactin 1 (p150, glued homolog, Drosophila)-HPRD,BioGRID11889140|14584027 
DCTN2DCTN50 | DYNAMITIN | RBP50dynactin 2 (p50)Two-hybridBioGRID11889140 
DCXDBCN | DC | LISX | SCLH | XLISdoublecortin-HPRD,BioGRID11001923 
DNAI1CILD1 | ICS | MGC26204 | PCDdynein, axonemal, intermediate chain 1-HPRD11889140 
DYNC1H1DHC1 | DHC1a | DKFZp686P2245 | DNCH1 | DNCL | DNECL | DYHC | Dnchc1 | HL-3 | KIAA0325 | p22dynein, cytoplasmic 1, heavy chain 1Affinity Capture-Western
Two-hybrid		BioGRID11889140 
HSPH1DKFZp686M05240 | HSP105 | HSP105A | HSP105B | KIAA0201 | NY-CO-25heat shock 105kDa/110kDa protein 1-HPRD14733918 
KARSKARS2 | KIAA0070 | KRSlysyl-tRNA synthetaseTwo-hybridBioGRID16169070 
NDE1FLJ20101 | HOM-TES-87 | NUDE | NUDE1nudE nuclear distribution gene E homolog 1 (A. nidulans)-HPRD11163258 
NDEL1DKFZp451M0318 | EOPA | MITAP1 | NUDELnudE nuclear distribution gene E homolog (A. nidulans)-like 1-HPRD,BioGRID11163260 
NUDCHNUDC | MNUDC | NPD011nuclear distribution gene C homolog (A. nidulans)-HPRD,BioGRID9601647 |11734602 
PAFAH1B1LIS1 | LIS2 | MDCR | MDS | PAFAHplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa-HPRD,BioGRID11889140 
PAFAH1B2-platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa-HPRD,BioGRID10727864 
PAFAH1B3-platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa-HPRD,BioGRID10727864 
TUBA1AB-ALPHA-1 | FLJ25113 | LIS3 | TUBA3tubulin, alpha 1aReconstituted ComplexBioGRID9384577 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ETHER_LIPID_METABOLISM 3315All SZGR genes in this pathway
PID_REELIN_PATHWAY 2929All SZGR genes in this pathway
PID_LIS1_PATHWAY 2822All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 6643All SZGR genes in this pathway
REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES 5938All SZGR genes in this pathway
REACTOME_MITOTIC_M_M_G1_PHASES 17298All SZGR genes in this pathway
REACTOME_MITOTIC_G2_G2_M_PHASES 8150All SZGR genes in this pathway
REACTOME_DNA_REPLICATION 192110All SZGR genes in this pathway
REACTOME_MITOTIC_PROMETAPHASE 8751All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
GARY_CD5_TARGETS_DN 431263All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_UP 181108All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_DN 12479All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
SCHWAB_TARGETS_OF_BMYB_POLYMORPHIC_VARIANTS_DN 1712All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP 6955All SZGR genes in this pathway
GEORGES_CELL_CYCLE_MIR192_TARGETS 6246All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
ONDER_CDH1_TARGETS_1_DN 169102All SZGR genes in this pathway
GOLDRATH_HOMEOSTATIC_PROLIFERATION 171102All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
KAAB_FAILED_HEART_ATRIUM_DN 14199All SZGR genes in this pathway
JIANG_AGING_CEREBRAL_CORTEX_UP 3627All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
ZHU_CMV_24_HR_DN 9164All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D6 3725All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_DN 312203All SZGR genes in this pathway
ZHU_CMV_ALL_DN 12893All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN 165106All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
LY_AGING_OLD_DN 5635All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G6 153112All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C5 4636All SZGR genes in this pathway
GENTILE_UV_LOW_DOSE_DN 6746All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_DN 10164All SZGR genes in this pathway
JIANG_AGING_HYPOTHALAMUS_UP 4731All SZGR genes in this pathway
OUILLETTE_CLL_13Q14_DELETION_UP 7440All SZGR genes in this pathway
DE_YY1_TARGETS_DN 9264All SZGR genes in this pathway
MATZUK_SPERMATID_DIFFERENTIATION 3726All SZGR genes in this pathway
BONCI_TARGETS_OF_MIR15A_AND_MIR16_1 9175All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
RAMPON_ENRICHED_LEARNING_ENVIRONMENT_EARLY_DN 1010All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/206273927461A,m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-1010401046m8hsa-miR-10aUACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10bUACCCUGUAGAACCGAAUUUGU
miR-1011811871Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-124/50625492555m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-125/351236223691A,m8hsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-130/30128682874m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-1441801871A,m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-15/16/195/424/497200520121A,m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-150228722941A,m8hsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-1512022081Ahsa-miR-151brainACUAGACUGAAGCUCCUUGAGG
miR-17-5p/20/93.mr/106/519.d287028771A,m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-181367336791Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-1825665731A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-1941391451Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-20535553561m8hsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-21423042310m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-226676731Ahsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-223354935551Ahsa-miR-223UGUCAGUUUGUCAAAUACCCC
miR-25/32/92/363/367893899m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-324-5p38441Ahsa-miR-324-5pCGCAUCCCCUAGGGCAUUGGUGU
miR-33026382644m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-33910391045m8hsa-miR-339UCCCUGUCCUCCAGGAGCUCA
miR-376c4314381A,m8hsa-miR-376cAACAUAGAGGAAAUUCCACG
miR-3811761821Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-4961011081A,m8hsa-miR-496AUUACAUGGCCAAUCUC
miR-503200620121Ahsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
miR-5431371431Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
miR-965675731Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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