Gene Page: FAM208B
Summary ?
| GeneID | 54906 |
| Symbol | FAM208B |
| Synonyms | C10orf18|bA318E3.2 |
| Description | family with sequence similarity 208 member B |
| Reference | HGNC:HGNC:23484|Ensembl:ENSG00000108021|Vega:OTTHUMG00000017605 |
| Gene type | protein-coding |
| Map location | 10p15.1 |
| Pascal p-value | 0.04 |
| Sherlock p-value | 0.191 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FAM208B | chr10 | 5790367 | C | T | NM_017782 | . | silent | Schizophrenia | DNM:Gulsuner_2013 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TPR | 0.89 | 0.91 |
| ZNF397 | 0.89 | 0.92 |
| TAF1 | 0.89 | 0.92 |
| RFC1 | 0.89 | 0.90 |
| YTHDC1 | 0.89 | 0.90 |
| RUFY1 | 0.89 | 0.89 |
| PTPN12 | 0.88 | 0.88 |
| LRCH3 | 0.88 | 0.92 |
| PCM1 | 0.88 | 0.91 |
| PHF3 | 0.88 | 0.91 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.68 | -0.77 |
| IFI27 | -0.68 | -0.77 |
| MT-CO2 | -0.66 | -0.75 |
| ENHO | -0.64 | -0.79 |
| AF347015.27 | -0.64 | -0.72 |
| HIGD1B | -0.64 | -0.75 |
| CXCL14 | -0.63 | -0.73 |
| AF347015.21 | -0.63 | -0.77 |
| PTH1R | -0.63 | -0.68 |
| FXYD1 | -0.63 | -0.72 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| THUM SYSTOLIC HEART FAILURE DN | 244 | 147 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC1 TARGETS UP | 457 | 269 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC1 AND HDAC2 TARGETS UP | 238 | 144 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC3 TARGETS UP | 501 | 327 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP | 552 | 347 | All SZGR 2.0 genes in this pathway |
| MCBRYAN PUBERTAL BREAST 4 5WK UP | 271 | 175 | All SZGR 2.0 genes in this pathway |
| HAMAI APOPTOSIS VIA TRAIL UP | 584 | 356 | All SZGR 2.0 genes in this pathway |
| SEIDEN ONCOGENESIS BY MET | 88 | 53 | All SZGR 2.0 genes in this pathway |
| FARMER BREAST CANCER APOCRINE VS LUMINAL | 326 | 213 | All SZGR 2.0 genes in this pathway |
| FARMER BREAST CANCER APOCRINE VS BASAL | 330 | 217 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS UP | 424 | 268 | All SZGR 2.0 genes in this pathway |
| HADDAD B LYMPHOCYTE PROGENITOR | 293 | 193 | All SZGR 2.0 genes in this pathway |
| FOSTER TOLERANT MACROPHAGE DN | 409 | 268 | All SZGR 2.0 genes in this pathway |
| ZHANG TLX TARGETS 36HR DN | 185 | 116 | All SZGR 2.0 genes in this pathway |
| CHANDRAN METASTASIS DN | 306 | 191 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 DN | 918 | 550 | All SZGR 2.0 genes in this pathway |