Gene Page: ZNF821

Summary ?
GeneID55565
SymbolZNF821
Synonyms-
Descriptionzinc finger protein 821
ReferenceHGNC:HGNC:28043|Ensembl:ENSG00000102984|HPRD:14244|Vega:OTTHUMG00000176874
Gene typeprotein-coding
Map location16q22.2
Pascal p-value0.212
DEG p-valueDEG:Sanders_2014:DS1_p=-0.152:DS1_beta=0.023100:DS2_p=7.11e-01:DS2_beta=-0.018:DS2_FDR=8.62e-01
Fetal beta1.591
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DEG:Sanders_2013MicroarrayWhole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls.
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg064644321671917996ZNF8218.01E-9-0.0083.83E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6734526chr25616370ZNF821555650.18trans
rs16829545chr2151977407ZNF821555653.552E-10trans
rs3845734chr2171125572ZNF821555650.1trans
rs7584986chr2184111432ZNF821555650.04trans
rs17762315chr576807576ZNF821555656.907E-4trans
rs7729096chr576835927ZNF821555650.04trans
rs7787830chr798797019ZNF821555650.01trans
rs2393316chr1059333070ZNF821555650.14trans
rs16955618chr1529937543ZNF821555651.489E-11trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AC112641.20.830.88
PITPNM20.800.84
DLGAP10.780.79
AC021534.20.780.85
THRB0.780.80
ARHGEF30.780.82
PKNOX20.770.80
KCNV10.770.84
CAMKK20.770.78
IQSEC20.770.81
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RAB13-0.50-0.58
DBI-0.48-0.51
RAB34-0.47-0.52
MYL12A-0.46-0.52
PECI-0.45-0.51
NKAIN4-0.45-0.54
AP002478.3-0.42-0.45
C1orf61-0.41-0.48
ACAA2-0.41-0.40
RHOC-0.41-0.46

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178111All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS DN 13588All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177132All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242146All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549316All SZGR 2.0 genes in this pathway