Gene Page: RUFY2
Summary ?
| GeneID | 55680 |
| Symbol | RUFY2 |
| Synonyms | RABIP4R|ZFYVE13 |
| Description | RUN and FYVE domain containing 2 |
| Reference | MIM:610328|HGNC:HGNC:19761|Ensembl:ENSG00000204130|HPRD:11526|Vega:OTTHUMG00000018353 |
| Gene type | protein-coding |
| Map location | 10q21.3 |
| Pascal p-value | 0.856 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg00855501 | 10 | 70167258 | RUFY2 | 2.19E-8 | -0.012 | 7.35E-6 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs2417941 | chr12 | 21017795 | RUFY2 | 55680 | 0.19 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ZFP64 | 0.94 | 0.92 |
| PCIF1 | 0.94 | 0.94 |
| RBM14 | 0.94 | 0.94 |
| PCBP1 | 0.93 | 0.91 |
| ZNF574 | 0.93 | 0.92 |
| TRIM28 | 0.93 | 0.92 |
| DEDD | 0.93 | 0.90 |
| THAP11 | 0.93 | 0.90 |
| U2AF2 | 0.93 | 0.92 |
| SIGMAR1 | 0.93 | 0.92 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.74 | -0.85 |
| MT-CO2 | -0.74 | -0.86 |
| AF347015.27 | -0.73 | -0.86 |
| AF347015.8 | -0.71 | -0.85 |
| AF347015.33 | -0.70 | -0.82 |
| MT-CYB | -0.70 | -0.83 |
| C5orf53 | -0.70 | -0.75 |
| AF347015.21 | -0.69 | -0.90 |
| IFI27 | -0.67 | -0.77 |
| AF347015.15 | -0.67 | -0.81 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ONKEN UVEAL MELANOMA UP | 783 | 507 | All SZGR 2.0 genes in this pathway |
| WANG LMO4 TARGETS DN | 352 | 225 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE FIMA UP | 544 | 308 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | All SZGR 2.0 genes in this pathway |
| YAUCH HEDGEHOG SIGNALING PARACRINE DN | 264 | 159 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 DN | 918 | 550 | All SZGR 2.0 genes in this pathway |