Gene Page: CNDP2

Summary ?
GeneID55748
SymbolCNDP2
SynonymsCN2|CPGL|HEL-S-13|HsT2298|PEPA
DescriptionCNDP dipeptidase 2 (metallopeptidase M20 family)
ReferenceMIM:169800|HGNC:HGNC:24437|Ensembl:ENSG00000133313|HPRD:09893|Vega:OTTHUMG00000132853
Gene typeprotein-coding
Map location18q22.3
Pascal p-value0.667
Sherlock p-value0.957
DMG2 (# studies)
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Nucleus accumbens basal ganglia
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Nishioka_2013Genome-wide DNA methylation analysisThe authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 2
DNM:Gulsuner_2013Whole Exome Sequencing analysis155 DNMs identified by exome sequencing of quads or trios of schizophrenia individuals and their parents.

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
CNDP2chr1872180842ACNM_001168499
NM_018235		p.180E>A
p.264E>A		missense
missense		SchizophreniaDNM:Gulsuner_2013

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg017947111872163198CNDP2-0.0230.26DMG:Nishioka_2013
cg036690521872164002CNDP21.26E-8-0.0075.11E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs80830011872165058CNDP2ENSG00000133313.107.43746E-70.032007gtex_brain_ba24
rs37645091872167124CNDP2ENSG00000133313.106.75222E-70.034073gtex_brain_ba24
rs80841091872168312CNDP2ENSG00000133313.106.70843E-70.035261gtex_brain_ba24
rs80844101872168486CNDP2ENSG00000133313.106.70843E-70.035435gtex_brain_ba24
rs72292561872169129CNDP2ENSG00000133313.106.70843E-70.036078gtex_brain_ba24
rs72415581872169267CNDP2ENSG00000133313.106.70843E-70.036216gtex_brain_ba24
rs346762121872170006CNDP2ENSG00000133313.106.70843E-70.036955gtex_brain_ba24
rs48915591872170397CNDP2ENSG00000133313.106.71091E-70.037346gtex_brain_ba24
rs129711201872174023CNDP2ENSG00000133313.102.66506E-60.0310972gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CHCHD100.700.57
KB-1839H6.10.700.56
TMEM420.700.66
FAM71E10.690.65
FAM98C0.690.67
TUSC20.680.64
PGP0.680.69
FDX1L0.670.69
HSD11B1L0.670.68
FAM108A40.670.64
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
EIF5B-0.38-0.47
THOC2-0.38-0.38
MAP4K4-0.34-0.33
TOP2B-0.34-0.24
ZEB2-0.34-0.30
ZNF326-0.33-0.33
CEP170-0.33-0.21
RBMX2-0.33-0.41
AC005035.1-0.33-0.34
TAF1A-0.33-0.28

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME SULFUR AMINO ACID METABOLISM 2417All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200136All SZGR 2.0 genes in this pathway
REACTOME BIOLOGICAL OXIDATIONS 13991All SZGR 2.0 genes in this pathway
REACTOME GLUTATHIONE CONJUGATION 2313All SZGR 2.0 genes in this pathway
REACTOME PHASE II CONJUGATION 7042All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431263All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN 234147All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION DN 8454All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517309All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP 205126All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT UP 165100All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP 428266All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354216All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS DN 14593All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY UP 13484All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491316All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 5 3022All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway