Summary ?
GeneID55814
SymbolBDP1
SynonymsHSA238520|TAF3B1|TFC5|TFIIIB''|TFIIIB150|TFIIIB90|TFNR
DescriptionB double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
ReferenceMIM:607012|HGNC:HGNC:13652|Ensembl:ENSG00000145734|HPRD:06114|Vega:OTTHUMG00000162506
Gene typeprotein-coding
Map location5q13
Pascal p-value0.466
Fetal beta0.81
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg07851057570751686BDP14.11E-7-0.4370.006DMG:Wockner_2014
cg22034268570848529BDP11.67E-50.3140.015DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16829545chr2151977407BDP1558140.11trans
rs758989chr744203005BDP1558140.06trans
rs1303722chr744219073BDP1558140.19trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HELZ0.920.93
UBN20.910.92
SLC12A60.910.92
BIRC60.910.91
PCNX0.910.92
KIAA16320.910.91
KIAA20180.910.92
KIF1B0.900.92
CRKRS0.900.92
HUWE10.900.90
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.69-0.77
HIGD1B-0.68-0.78
MT-CO2-0.68-0.76
IFI27-0.67-0.75
AF347015.21-0.66-0.79
FXYD1-0.66-0.74
CXCL14-0.64-0.72
CST3-0.64-0.74
C1orf54-0.63-0.80
S100A16-0.63-0.71

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
SENESE HDAC1 TARGETS UP 457269All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501327All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265158All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
MARIADASON REGULATED BY HISTONE ACETYLATION DN 5430All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011592All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
BILANGES SERUM SENSITIVE VIA TSC2 3925All SZGR 2.0 genes in this pathway