Gene Page: DMAP1
Summary ?
| GeneID | 55929 |
| Symbol | DMAP1 |
| Synonyms | DNMAP1|DNMTAP1|EAF2|MEAF2|SWC4 |
| Description | DNA methyltransferase 1 associated protein 1 |
| Reference | MIM:605077|HGNC:HGNC:18291|Ensembl:ENSG00000178028|HPRD:05465|Vega:OTTHUMG00000007577 |
| Gene type | protein-coding |
| Map location | 1p34 |
| Pascal p-value | 0.049 |
| Sherlock p-value | 0.771 |
| eGene | Putamen basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs61442919 | 1 | 44020987 | DMAP1 | ENSG00000178028.9 | 1.23039E-6 | 0 | -658140 | gtex_brain_putamen_basal |
| rs568639 | 1 | 44086080 | DMAP1 | ENSG00000178028.9 | 3.97133E-7 | 0 | -593047 | gtex_brain_putamen_basal |
| rs2970606 | 1 | 44103498 | DMAP1 | ENSG00000178028.9 | 5.68365E-7 | 0 | -575629 | gtex_brain_putamen_basal |
| rs581005 | 1 | 44106986 | DMAP1 | ENSG00000178028.9 | 1.32919E-6 | 0 | -572141 | gtex_brain_putamen_basal |
| rs694197 | 1 | 44107956 | DMAP1 | ENSG00000178028.9 | 2.35086E-6 | 0 | -571171 | gtex_brain_putamen_basal |
| rs483679 | 1 | 44108119 | DMAP1 | ENSG00000178028.9 | 1.66857E-6 | 0 | -571008 | gtex_brain_putamen_basal |
| rs6429631 | 1 | 44113441 | DMAP1 | ENSG00000178028.9 | 1.38663E-6 | 0 | -565686 | gtex_brain_putamen_basal |
| rs519357 | 1 | 44115022 | DMAP1 | ENSG00000178028.9 | 1.96165E-7 | 0 | -564105 | gtex_brain_putamen_basal |
| rs631758 | 1 | 44115054 | DMAP1 | ENSG00000178028.9 | 3.32242E-6 | 0 | -564073 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| KIAA1543 | 0.96 | 0.97 |
| FAM171A2 | 0.96 | 0.96 |
| GRAMD1A | 0.96 | 0.96 |
| TNRC4 | 0.95 | 0.96 |
| FGD1 | 0.95 | 0.97 |
| DTX1 | 0.95 | 0.95 |
| GPSM1 | 0.94 | 0.95 |
| RUSC1 | 0.94 | 0.95 |
| STRN4 | 0.94 | 0.96 |
| PODXL2 | 0.94 | 0.96 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.78 | -0.91 |
| AF347015.27 | -0.77 | -0.91 |
| MT-CO2 | -0.77 | -0.91 |
| AF347015.33 | -0.77 | -0.90 |
| S100B | -0.75 | -0.86 |
| MT-CYB | -0.75 | -0.89 |
| AF347015.8 | -0.74 | -0.90 |
| HLA-F | -0.74 | -0.78 |
| HEPN1 | -0.74 | -0.79 |
| AIFM3 | -0.74 | -0.78 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER DN | 540 | 340 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |