Gene Page: PCDHB7
Summary ?
| GeneID | 56129 |
| Symbol | PCDHB7 |
| Synonyms | PCDH-BETA7 |
| Description | protocadherin beta 7 |
| Reference | MIM:606333|HGNC:HGNC:8692|Ensembl:ENSG00000113212|HPRD:07562|Vega:OTTHUMG00000129608 |
| Gene type | protein-coding |
| Map location | 5q31 |
| Pascal p-value | 0.031 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.0032 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ARPC2 | 0.73 | 0.78 |
| EIF2B2 | 0.73 | 0.76 |
| NFKBIE | 0.73 | 0.81 |
| DDX49 | 0.72 | 0.75 |
| VPS26B | 0.72 | 0.79 |
| MLLT11 | 0.72 | 0.79 |
| TRAPPC4 | 0.72 | 0.71 |
| MLX | 0.72 | 0.77 |
| PIK3R2 | 0.72 | 0.78 |
| STMN4 | 0.72 | 0.77 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.27 | -0.60 | -0.71 |
| AF347015.33 | -0.60 | -0.70 |
| AF347015.31 | -0.59 | -0.69 |
| HEPN1 | -0.59 | -0.66 |
| MT-CO2 | -0.59 | -0.69 |
| AIFM3 | -0.58 | -0.66 |
| MT-CYB | -0.58 | -0.68 |
| AF347015.8 | -0.58 | -0.69 |
| BDH2 | -0.58 | -0.67 |
| TSC22D4 | -0.57 | -0.66 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005509 | calcium ion binding | NAS | - | |
| GO:0005515 | protein binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007155 | cell adhesion | IEA | - | |
| GO:0007156 | homophilic cell adhesion | IEA | - | |
| GO:0016339 | calcium-dependent cell-cell adhesion | NAS | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0016021 | integral to membrane | NAS | - | |
| GO:0005886 | plasma membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GOZGIT ESR1 TARGETS DN | 781 | 465 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN IPS WITH HCP H3K27ME3 | 102 | 76 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES HCP WITH H3K27ME3 | 41 | 30 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3 UNMETHYLATED | 228 | 119 | All SZGR 2.0 genes in this pathway |
| WANG MLL TARGETS | 289 | 188 | All SZGR 2.0 genes in this pathway |