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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: PAK7

Summary

GeneID

57144

Symbol

PAK7

Synonyms

KIAA1264|MGC26232|PAK5

Description

p21 protein (Cdc42/Rac)-activated kinase 7

Locus tag

RP5-1119D9.3

Gene type

protein-coding

Map location

20p12

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.046

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0005515

protein binding

IPI

17353931

GO:0005524

ATP binding

IEA

GO:0004674

protein serine/threonine kinase activity

IEA

GO:0016740

transferase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006468

protein amino acid phosphorylation

IEA

GO:0006916

anti-apoptosis

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005739

mitochondrion

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AP2S1	AP17 \| AP17-DELTA \| CLAPS2	adaptor-related protein complex 2, sigma 1 subunit	Affinity Capture-MS	BioGRID	17353931
CCDC59	BR22 \| DKFZp686K1021 \| FLJ10294 \| HSPC128 \| TAP26	coiled-coil domain containing 59	Affinity Capture-MS	BioGRID	17353931
CDC42	CDC42Hs \| G25K	cell division cycle 42 (GTP binding protein, 25kDa)	-	HPRD,BioGRID	11756552 \|12032833
FHL3	MGC19547 \| MGC23614 \| MGC8696 \| SLIM2	four and a half LIM domains 3	Two-hybrid	BioGRID	16189514
LZTS2	KIAA1813 \| LAPSER1	leucine zipper, putative tumor suppressor 2	Two-hybrid	BioGRID	16189514
PDLIM7	LMP1	PDZ and LIM domain 7 (enigma)	Two-hybrid	BioGRID	16189514
RAC1	MGC111543 \| MIG5 \| TC-25 \| p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	-	HPRD,BioGRID	11756552
RPA3	REPA3	replication protein A3, 14kDa	Affinity Capture-MS	BioGRID	17353931
S100A7	PSOR1 \| S100A7c	S100 calcium binding protein A7	Affinity Capture-MS	BioGRID	17353931
S100A9	60B8AG \| CAGB \| CFAG \| CGLB \| L1AG \| LIAG \| MAC387 \| MIF \| MRP14 \| NIF \| P14	S100 calcium binding protein A9	Affinity Capture-MS	BioGRID	17353931
TUBGCP4	76P \| FLJ14797 \| GCP4	tubulin, gamma complex associated protein 4	Two-hybrid	BioGRID	16189514

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_ERBB_SIGNALING_PATHWAY	87	71	All SZGR genes in this pathway
KEGG_AXON_GUIDANCE	129	103	All SZGR genes in this pathway
KEGG_FOCAL_ADHESION	201	138	All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY	108	89	All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	216	144	All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA	70	60	All SZGR genes in this pathway
BIOCARTA_AGR_PATHWAY	36	31	All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	67	54	All SZGR genes in this pathway
SIG_CHEMOTAXIS	45	37	All SZGR genes in this pathway
SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	35	25	All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY	82	62	All SZGR genes in this pathway
ST_T_CELL_SIGNAL_TRANSDUCTION	45	33	All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE	251	188	All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_RAC	14	11	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ROBO_RECEPTOR	30	26	All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_UP	456	228	All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP	191	128	All SZGR genes in this pathway
WONG_IFNA2_RESISTANCE_DN	34	20	All SZGR genes in this pathway
MCCABE_BOUND_BY_HOXC6	469	239	All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP	439	257	All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN	546	362	All SZGR genes in this pathway
MEISSNER_ES_ICP_WITH_H3K4ME3_AND_H3K27ME3	14	8	All SZGR genes in this pathway
MEISSNER_BRAIN_ICP_WITH_H3K4ME3	32	17	All SZGR genes in this pathway
MIKKELSEN_MEF_ICP_WITH_H3K4ME3_AND_H3K27ME3	38	34	All SZGR genes in this pathway
MIKKELSEN_IPS_ICP_WITH_H3K4ME3_AND_H327ME3	126	83	All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3_AND_H3K27ME3	137	85	All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL	177	132	All SZGR genes in this pathway
HOELZEL_NF1_TARGETS_DN	115	73	All SZGR genes in this pathway
GOBERT_CORE_OLIGODENDROCYTE_DIFFERENTIATION	40	28	All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES	462	273	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-10	311	317	1A	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	311	317	1A	hsa-miR-10b	UACCCUGUAGAACCGAAUUUGU
miR-101	1993	1999	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-135	1422	1428	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	1422	1428	m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-139	1337	1343	m8	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-139	1337	1343	m8	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-144	1993	1999	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-145	1636	1643	1A,m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-15/16/195/424/497	1247	1253	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d	394	400	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-181	1267	1273	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-185	179	186	1A,m8	hsa-miR-185^brain	UGGAGAGAAAGGCAGUUC
miR-186	584	591	1A,m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-191	284	290	1A	hsa-miR-191^brain	CAACGGAAUCCCAAAAGCAGCU
miR-200bc/429	1104	1111	1A,m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-208	165	171	1A	hsa-miR-208	AUAAGACGAGCAAAAAGCUUGU
miR-24	748	754	1A	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-30-5p	521	527	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-320	627	634	1A,m8	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-323	1220	1226	m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-369-3p	232	238	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	232	238	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-375	539	545	1A	hsa-miR-375	UUUGUUCGUUCGGCUCGCGUGA
miR-376c	1811	1817	1A	hsa-miR-376c	AACAUAGAGGAAAUUCCACG
miR-495	1428	1434	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-499	165	171	1A	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA
miR-543	1268	1274	m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-93.hd/291-3p/294/295/302/372/373/520	393	399	m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.