SZGR2

Summary ?

GeneID	57144
Symbol	PAK7
Synonyms	PAK5
Description	p21 protein (Cdc42/Rac)-activated kinase 7
Reference	MIM:608038\|HGNC:HGNC:15916\|Ensembl:ENSG00000101349\|HPRD:06423\|Vega:OTTHUMG00000031857
Gene type	protein-coding
Map location	20p12
Pascal p-value	0.731
Sherlock p-value	0.668
Fetal beta	1.226
DMG	1 (# studies)
eGene	Cerebellum
Support	G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I	Genome scan meta-analysis	Psr: 0.046
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg18815779	20	9819789	PAK7	9.87E-5	-0.313	0.028	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0005515	protein binding	IPI		17353931
GO:0005524	ATP binding	IEA		-
GO:0004674	protein serine/threonine kinase activity	IEA		-
GO:0016740	transferase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0006916	anti-apoptosis	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005739	mitochondrion	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AP2S1	AP17 \| AP17-DELTA \| CLAPS2	adaptor-related protein complex 2, sigma 1 subunit	Affinity Capture-MS	BioGRID	17353931
CCDC59	BR22 \| DKFZp686K1021 \| FLJ10294 \| HSPC128 \| TAP26	coiled-coil domain containing 59	Affinity Capture-MS	BioGRID	17353931
CDC42	CDC42Hs \| G25K	cell division cycle 42 (GTP binding protein, 25kDa)	-	HPRD,BioGRID	11756552 \|12032833
FHL3	MGC19547 \| MGC23614 \| MGC8696 \| SLIM2	four and a half LIM domains 3	Two-hybrid	BioGRID	16189514
LZTS2	KIAA1813 \| LAPSER1	leucine zipper, putative tumor suppressor 2	Two-hybrid	BioGRID	16189514
PDLIM7	LMP1	PDZ and LIM domain 7 (enigma)	Two-hybrid	BioGRID	16189514
RAC1	MGC111543 \| MIG5 \| TC-25 \| p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	-	HPRD,BioGRID	11756552
RPA3	REPA3	replication protein A3, 14kDa	Affinity Capture-MS	BioGRID	17353931
S100A7	PSOR1 \| S100A7c	S100 calcium binding protein A7	Affinity Capture-MS	BioGRID	17353931
S100A9	60B8AG \| CAGB \| CFAG \| CGLB \| L1AG \| LIAG \| MAC387 \| MIF \| MRP14 \| NIF \| P14	S100 calcium binding protein A9	Affinity Capture-MS	BioGRID	17353931
TUBGCP4	76P \| FLJ14797 \| GCP4	tubulin, gamma complex associated protein 4	Two-hybrid	BioGRID	16189514

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG ERBB SIGNALING PATHWAY	87	71	All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE	129	103	All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION	201	138	All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY	108	89	All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON	216	144	All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA	70	60	All SZGR 2.0 genes in this pathway
BIOCARTA AGR PATHWAY	36	31	All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN CARDIAC MYOCTES	67	54	All SZGR 2.0 genes in this pathway
SIG CHEMOTAXIS	45	37	All SZGR 2.0 genes in this pathway
SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	35	25	All SZGR 2.0 genes in this pathway
ST INTEGRIN SIGNALING PATHWAY	82	62	All SZGR 2.0 genes in this pathway
ST T CELL SIGNAL TRANSDUCTION	45	33	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF RAC	14	11	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ROBO RECEPTOR	30	26	All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP	456	228	All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS A UP	191	128	All SZGR 2.0 genes in this pathway
WONG IFNA2 RESISTANCE DN	34	20	All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6	469	239	All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP	439	257	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN	546	362	All SZGR 2.0 genes in this pathway
MEISSNER ES ICP WITH H3K4ME3 AND H3K27ME3	14	8	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN ICP WITH H3K4ME3	32	17	All SZGR 2.0 genes in this pathway
MIKKELSEN MEF ICP WITH H3K4ME3 AND H3K27ME3	38	34	All SZGR 2.0 genes in this pathway
MIKKELSEN IPS ICP WITH H3K4ME3 AND H327ME3	126	83	All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 AND H3K27ME3	137	85	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL	177	132	All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS DN	115	73	All SZGR 2.0 genes in this pathway
GOBERT CORE OLIGODENDROCYTE DIFFERENTIATION	40	28	All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES	462	273	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-10	311	317	1A	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	311	317	1A	hsa-miR-10b	UACCCUGUAGAACCGAAUUUGU
miR-101	1993	1999	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-135	1422	1428	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	1422	1428	m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-139	1337	1343	m8	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-139	1337	1343	m8	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-144	1993	1999	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-145	1636	1643	1A,m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-15/16/195/424/497	1247	1253	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d	394	400	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-181	1267	1273	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-185	179	186	1A,m8	hsa-miR-185^brain	UGGAGAGAAAGGCAGUUC
miR-186	584	591	1A,m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-191	284	290	1A	hsa-miR-191^brain	CAACGGAAUCCCAAAAGCAGCU
miR-200bc/429	1104	1111	1A,m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-208	165	171	1A	hsa-miR-208	AUAAGACGAGCAAAAAGCUUGU
miR-24	748	754	1A	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-30-5p	521	527	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-320	627	634	1A,m8	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-323	1220	1226	m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-369-3p	232	238	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	232	238	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-375	539	545	1A	hsa-miR-375	UUUGUUCGUUCGGCUCGCGUGA
miR-376c	1811	1817	1A	hsa-miR-376c	AACAUAGAGGAAAUUCCACG
miR-495	1428	1434	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-499	165	171	1A	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA
miR-543	1268	1274	m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-93.hd/291-3p/294/295/302/372/373/520	393	399	m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: PAK7