Gene Page: GPR158
Summary ?
| GeneID | 57512 |
| Symbol | GPR158 |
| Synonyms | - |
| Description | G protein-coupled receptor 158 |
| Reference | MIM:614573|HGNC:HGNC:23689|Ensembl:ENSG00000151025|HPRD:13601|Vega:OTTHUMG00000017832 |
| Gene type | protein-coding |
| Map location | 10p12.1 |
| Pascal p-value | 0.022 |
| Sherlock p-value | 0.939 |
| Fetal beta | -3.732 |
| DMG | 1 (# studies) |
| Support | GPCR SIGNALLING G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS CompositeSet Darnell FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg03826317 | 10 | 25465503 | GPR158 | 1.4E-9 | -0.014 | 1.38E-6 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PRKCB | 0.89 | 0.89 |
| ST8SIA3 | 0.88 | 0.89 |
| PARK2 | 0.86 | 0.83 |
| PPP2R2C | 0.86 | 0.85 |
| HOMER1 | 0.86 | 0.82 |
| CNKSR2 | 0.85 | 0.81 |
| PLCB1 | 0.85 | 0.79 |
| RASGRP1 | 0.85 | 0.86 |
| ATP2B1 | 0.85 | 0.81 |
| ARHGEF9 | 0.85 | 0.78 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| BCL7C | -0.44 | -0.47 |
| HEBP2 | -0.41 | -0.47 |
| RPL28 | -0.39 | -0.39 |
| IMPA2 | -0.38 | -0.43 |
| NME4 | -0.38 | -0.44 |
| RAB13 | -0.38 | -0.46 |
| GRTP1 | -0.37 | -0.36 |
| RPL18 | -0.37 | -0.34 |
| HYAL2 | -0.37 | -0.34 |
| RPL35 | -0.37 | -0.35 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| WANG LMO4 TARGETS UP | 372 | 227 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA ANAPLASTIC UP | 722 | 443 | All SZGR 2.0 genes in this pathway |
| RICKMAN HEAD AND NECK CANCER A | 100 | 63 | All SZGR 2.0 genes in this pathway |
| BENPORATH SUZ12 TARGETS | 1038 | 678 | All SZGR 2.0 genes in this pathway |
| CHANDRAN METASTASIS UP | 221 | 135 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3 UNMETHYLATED | 228 | 119 | All SZGR 2.0 genes in this pathway |
| KUMAR PATHOGEN LOAD BY MACROPHAGES | 275 | 155 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |