Gene Page: RPRD1B
Summary ?
| GeneID | 58490 |
| Symbol | RPRD1B |
| Synonyms | C20orf77|CREPT|NET60|dJ1057B20.2 |
| Description | regulation of nuclear pre-mRNA domain containing 1B |
| Reference | MIM:614694|HGNC:HGNC:16209|Ensembl:ENSG00000101413|HPRD:08513|Vega:OTTHUMG00000032434 |
| Gene type | protein-coding |
| Map location | 20q11.23 |
| Pascal p-value | 0.092 |
| Fetal beta | 0.593 |
| eGene | Cerebellar Hemisphere Cerebellum Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7132043 | chr12 | 80968399 | RPRD1B | 58490 | 0.13 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SLC30A9 | 0.91 | 0.88 |
| PPP2CA | 0.90 | 0.87 |
| PPME1 | 0.90 | 0.88 |
| STAU2 | 0.90 | 0.87 |
| KLRAQ1 | 0.89 | 0.88 |
| FAM49B | 0.89 | 0.86 |
| RAB2A | 0.89 | 0.86 |
| DNAJA2 | 0.89 | 0.85 |
| MORF4L2 | 0.89 | 0.85 |
| RHOT1 | 0.88 | 0.86 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.26 | -0.70 | -0.60 |
| MT-CO2 | -0.69 | -0.59 |
| AF347015.2 | -0.68 | -0.56 |
| AF347015.8 | -0.67 | -0.58 |
| AF347015.33 | -0.67 | -0.58 |
| AF347015.21 | -0.66 | -0.55 |
| MT-CYB | -0.66 | -0.57 |
| HIGD1B | -0.66 | -0.59 |
| FXYD1 | -0.66 | -0.62 |
| AF347015.31 | -0.66 | -0.57 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BERENJENO TRANSFORMED BY RHOA UP | 536 | 340 | All SZGR 2.0 genes in this pathway |
| KONG E2F3 TARGETS | 97 | 58 | All SZGR 2.0 genes in this pathway |
| DOUGLAS BMI1 TARGETS DN | 314 | 188 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY E2F4 UNSTIMULATED | 728 | 415 | All SZGR 2.0 genes in this pathway |