Gene Page: JAM2

Summary ?
GeneID58494
SymbolJAM2
SynonymsC21orf43|CD322|JAM-B|JAMB|PRO245|VE-JAM|VEJAM
Descriptionjunctional adhesion molecule 2
ReferenceMIM:606870|HGNC:HGNC:14686|Ensembl:ENSG00000154721|HPRD:06041|Vega:OTTHUMG00000078441
Gene typeprotein-coding
Map location21q21.2
Pascal p-value0.082
Sherlock p-value0.694
Fetal beta-0.33
DMG2 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Nishioka_2013Genome-wide DNA methylation analysisThe authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 2
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg226273902127012066JAM22.536E-4-0.2240.037DMG:Wockner_2014
cg033823042127012176JAM2-0.020.26DMG:Nishioka_2013

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17131472chr191962966JAM2584940.06trans
rs1691463chr384914366JAM2584940.03trans
rs2922180chr3125280472JAM2584940.17trans
rs2976809chr3125451738JAM2584940.04trans
rs10050805chr530805352JAM2584940.08trans
rs17135501chr62704474JAM2584942.549E-5trans
rs17135521chr62707631JAM2584942.549E-5trans
snp_a-17879260JAM2584942.549E-5trans
rs6455226chr667930295JAM2584940.01trans
rs7841407chr89243427JAM2584940.1trans
rs7812588chr8136803829JAM2584940.18trans
rs4514358chr1043861923JAM2584940.19trans
rs1159612chr1085329057JAM2584940.16trans
rs10492573chr1343890007JAM2584940.18trans
rs9891406chr1734320983JAM2584940.04trans
rs6095741chr2048666589JAM2584940.01trans
rs1545676chrX93530472JAM2584940.03trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NDUFB50.860.79
C2orf640.860.75
NDUFA40.850.75
SDHB0.840.78
NDUFA90.840.75
COX4I10.840.76
AC025647.10.840.74
MRPS330.840.72
GSTO10.820.68
APOA1BP0.820.73
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
DMPK-0.43-0.50
AC005921.3-0.43-0.59
SMTN-0.42-0.55
IL3RA-0.42-0.60
AC010300.1-0.41-0.52
TNKS1BP1-0.41-0.38
BAT2D1-0.40-0.33
PRX-0.40-0.45
UPF3A-0.40-0.48
HDAC7-0.40-0.50

Section III. Gene Ontology annotation

Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0016337cell-cell adhesionNAS10779521 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005923tight junctionIEABrain (GO term level: 10)-
GO:0005886plasma membraneEXP17525755 
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneNAS10779521 
GO:0030054cell junctionIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CELL ADHESION MOLECULES CAMS 13493All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION 13486All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION 11878All SZGR 2.0 genes in this pathway
KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION 6844All SZGR 2.0 genes in this pathway
PID INTEGRIN1 PATHWAY 6644All SZGR 2.0 genes in this pathway
PID AMB2 NEUTROPHILS PATHWAY 4132All SZGR 2.0 genes in this pathway
PID INTEGRIN A4B1 PATHWAY 3324All SZGR 2.0 genes in this pathway
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 9165All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN CELL SURFACE INTERACTIONS 7948All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN 11679All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367220All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN 291176All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES SKIN UP 177113All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS A UP 191128All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN 164111All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 1 UP 11866All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM 302191All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART DN 4232All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
CLASPER LYMPHATIC VESSELS DURING METASTASIS DN 3623All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510309All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE DN 10868All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN 216143All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572352All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS GROWING 243155All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS UP 11265All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway
WANG MLL TARGETS 289188All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462273All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 227149All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489314All SZGR 2.0 genes in this pathway
DURAND STROMA NS UP 162103All SZGR 2.0 genes in this pathway
ZWANG CLASS 2 TRANSIENTLY INDUCED BY EGF 5129All SZGR 2.0 genes in this pathway