Gene Page: RALA

Summary
GeneID  5898
Symbol  RALA
Synonyms  MGC48949|RAL
Description  v-ral simian leukemia viral oncogene homolog A (ras related)
See related  HGNC:9839|MIM:179550|Ensembl:ENSG00000006451|HPRD:01549|
Locus tag  -
Gene type  protein-coding
Map location  7p15-p13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0309 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
KIAA10090.930.90
KIAA17310.930.91
C21orf660.910.90
ZNF8410.900.91
ZFC3H10.900.92
CSPP10.900.91
RBM60.900.88
CEP2900.900.87
CENPJ0.900.89
ZNF4710.900.88
Top 10 negatively co-expressed genes
AF347015.31-0.65-0.77
IFI27-0.64-0.76
ENHO-0.63-0.80
HIGD1B-0.63-0.77
MT-CO2-0.63-0.75
AF347015.27-0.61-0.71
TSC22D4-0.61-0.69
FXYD1-0.61-0.72
RAMP1-0.61-0.70
HLA-F-0.61-0.65
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI7673236 
GO:0005525GTP bindingTAS2550440 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007265Ras protein signal transductionEXP11520933 
GO:0006935chemotaxisTAS10848592 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARF1-ADP-ribosylation factor 1Reconstituted ComplexBioGRID9688545 
-HPRD12509462 
ARF6DKFZp564M0264ADP-ribosylation factor 6Affinity Capture-WesternBioGRID12509462 
CNKSR2CNK2 | KIAA0902 | KSR2connector enhancer of kinase suppressor of Ras 2-HPRD,BioGRID14597674 
CSDACSDA1 | DBPA | ZONABcold shock domain protein ARalA interacts with ZONAB. This interaction was modeled on a demonstrated interaction between human or canine RalA and canine ZONAB.BIND15592429 
EXOC1BM-102 | FLJ10893 | SEC3 | SEC3L1 | SEC3Pexocyst complex component 1-HPRD11406615 
EXOC2FLJ11026 | SEC5 | SEC5L1 | Sec5pexocyst complex component 2-HPRD,BioGRID12839989 
-HPRD11744922 |12624092 
|14525976 
RalA interacts with Sec5. This interaction was modelled on a demonstrated interaction between human RalA and Sec5 from an unspecified species.BIND15920473 
EXOC4MGC27170 | REC8 | SEC8 | SEC8L1 | Sec8pexocyst complex component 4-HPRD11406615 
EXOC72-5-3p | DKFZp686J04253 | EX070 | EXO70 | EXOC1 | Exo70p | FLJ40965 | FLJ46415 | YJL085Wexocyst complex component 7-HPRD11406615 
EXOC8EXO84 | Exo84p | SEC84exocyst complex component 8-HPRD,BioGRID14525976 
FLNAABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2filamin A, alpha (actin binding protein 280)-HPRD,BioGRID10051605 
HRASC-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1v-Ha-ras Harvey rat sarcoma viral oncogene homologTwo-hybridBioGRID11786539 
LRPAP1A2MRAP | A2RAP | HBP44 | MGC138272 | MRAP | RAPlow density lipoprotein receptor-related protein associated protein 1Reconstituted ComplexBioGRID11167825 
PLD1-phospholipase D1, phosphatidylcholine-specific-HPRD,BioGRID9207251 
RAB8BFLJ38125RAB8B, member RAS oncogene family-HPRD10889189 
RALBP1RIP1 | RLIP1 | RLIP76ralA binding protein 1-HPRD,BioGRID7673236 
RalA interacts with RalBP1.BIND15592429 
RalA interacts with RLIP76.BIND7673236 
RALGPS1KIAA0351 | RALGEF2 | RALGPS1ARal GEF with PH domain and SH3 binding motif 1-HPRD,BioGRID10889189 
RAP1AKREV-1 | KREV1 | RAP1 | SMGP21RAP1A, member of RAS oncogene familyTwo-hybridBioGRID11786539 
RAP2AK-REV | KREV | RAP2 | RbBP-30RAP2A, member of RAS oncogene familyTwo-hybridBioGRID11786539 
RAP2BMGC20484RAP2B, member of RAS oncogene familyTwo-hybridBioGRID11786539 
RGL2HKE1.5 | KE1.5 | RAB2Lral guanine nucleotide dissociation stimulator-like 2Two-hybridBioGRID8939933 
RGL4MGC119678 | MGC119680 | Rgrral guanine nucleotide dissociation stimulator-like 4-HPRD,BioGRID12874025 
TSC2FLJ43106 | LAM | TSC4tuberous sclerosis 2Affinity Capture-WesternBioGRID12842888 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_PANCREATIC_CANCER 7056All SZGR genes in this pathway
BIOCARTA_RAS_PATHWAY 2320All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY 8262All SZGR genes in this pathway
PID_ARF6_TRAFFICKING_PATHWAY 4934All SZGR genes in this pathway
PID_P38_ALPHA_BETA_PATHWAY 3125All SZGR genes in this pathway
PID_FOXO_PATHWAY 4943All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_RAS 2723All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_ERKS 3630All SZGR genes in this pathway
REACTOME_P38MAPK_EVENTS 1312All SZGR genes in this pathway
CHANDRAN_METASTASIS_TOP50_UP 3827All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_RED_DN 2519All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP 265158All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_UP 13784All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
CHOI_ATL_STAGE_PREDICTOR 4424All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYC 10874All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
OXFORD_RALA_TARGETS_DN 108All SZGR genes in this pathway
ASTON_MAJOR_DEPRESSIVE_DISORDER_DN 160110All SZGR genes in this pathway
BROCKE_APOPTOSIS_REVERSED_BY_IL6 14498All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
STOSSI_RESPONSE_TO_ESTRADIOL 5035All SZGR genes in this pathway
MAHAJAN_RESPONSE_TO_IL1A_DN 7657All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
WESTON_VEGFA_TARGETS 10871All SZGR genes in this pathway
MCCLUNG_CREB1_TARGETS_UP 10072All SZGR genes in this pathway
WESTON_VEGFA_TARGETS_3HR 7447All SZGR genes in this pathway
STEIN_ESRRA_TARGETS_UP 388234All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
CHUNG_BLISTER_CYTOTOXICITY_UP 13484All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_DN 175103All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
STEIN_ESRRA_TARGETS 535325All SZGR genes in this pathway
CHANDRAN_METASTASIS_UP 221135All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_10 6938All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
VANOEVELEN_MYOGENESIS_SIN3A_TARGETS 220133All SZGR genes in this pathway
PECE_MAMMARY_STEM_CELL_UP 14675All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/206146214681Ahsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-124.15946011A,m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5065946001Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-1534524581Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-1812382451A,m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-1837727791A,m8hsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-221/222241247m8hsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
miR-24183818441Ahsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-275195251Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-29176017661Ahsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-30-3p7985m8hsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-329638644m8hsa-miR-329brainAACACACCUGGUUAACCUCUUU
miR-34b389395m8hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
miR-369-3p3413471Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-3743413481A,m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-376176417701Ahsa-miR-376aAUCAUAGAGGAAAAUCCACGU
hsa-miR-376bAUCAUAGAGGAAAAUCCAUGUU
miR-4484524581Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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