SZGR2

Summary ?

GeneID	5898
Symbol	RALA
Synonyms	RAL
Description	v-ral simian leukemia viral oncogene homolog A (ras related)
Reference	MIM:179550\|HGNC:HGNC:9839\|Ensembl:ENSG00000006451\|HPRD:01549\|Vega:OTTHUMG00000128775
Gene type	protein-coding
Map location	7p15-p13
Pascal p-value	0.374
Sherlock p-value	0.492
Fetal beta	1.098
DMG	1 (# studies)
Support	INTRACELLULAR SIGNAL TRANSDUCTION G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.humanNRC G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0309

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg11610702	7	39773227	RALA	1.33E-11	-0.036	2.84E-7	DMG:Jaffe_2016

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
KIAA1009	0.93	0.90
KIAA1731	0.93	0.91
C21orf66	0.91	0.90
ZNF841	0.90	0.91
ZFC3H1	0.90	0.92
CSPP1	0.90	0.91
RBM6	0.90	0.88
CEP290	0.90	0.87
CENPJ	0.90	0.89
ZNF471	0.90	0.88

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.65	-0.77
IFI27	-0.64	-0.76
ENHO	-0.63	-0.80
HIGD1B	-0.63	-0.77
MT-CO2	-0.63	-0.75
AF347015.27	-0.61	-0.71
TSC22D4	-0.61	-0.69
FXYD1	-0.61	-0.72
RAMP1	-0.61	-0.70
HLA-F	-0.61	-0.65

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0005515	protein binding	IPI		7673236
GO:0005525	GTP binding	TAS		2550440
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007265	Ras protein signal transduction	EXP		11520933
GO:0006935	chemotaxis	TAS		10848592
GO:0044419	interspecies interaction between organisms	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005622	intracellular	IEA		-
GO:0005886	plasma membrane	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ARF1	-	ADP-ribosylation factor 1	Reconstituted Complex	BioGRID	9688545
ARF1	-	ADP-ribosylation factor 1	-	HPRD	12509462
ARF6	DKFZp564M0264	ADP-ribosylation factor 6	Affinity Capture-Western	BioGRID	12509462
CNKSR2	CNK2 \| KIAA0902 \| KSR2	connector enhancer of kinase suppressor of Ras 2	-	HPRD,BioGRID	14597674
CSDA	CSDA1 \| DBPA \| ZONAB	cold shock domain protein A	RalA interacts with ZONAB. This interaction was modeled on a demonstrated interaction between human or canine RalA and canine ZONAB.	BIND	15592429
EXOC1	BM-102 \| FLJ10893 \| SEC3 \| SEC3L1 \| SEC3P	exocyst complex component 1	-	HPRD	11406615
EXOC2	FLJ11026 \| SEC5 \| SEC5L1 \| Sec5p	exocyst complex component 2	-	HPRD,BioGRID	12839989
EXOC2	FLJ11026 \| SEC5 \| SEC5L1 \| Sec5p	exocyst complex component 2	-	HPRD	11744922 \|12624092 \|14525976
EXOC2	FLJ11026 \| SEC5 \| SEC5L1 \| Sec5p	exocyst complex component 2	RalA interacts with Sec5. This interaction was modelled on a demonstrated interaction between human RalA and Sec5 from an unspecified species.	BIND	15920473
EXOC4	MGC27170 \| REC8 \| SEC8 \| SEC8L1 \| Sec8p	exocyst complex component 4	-	HPRD	11406615
EXOC7	2-5-3p \| DKFZp686J04253 \| EX070 \| EXO70 \| EXOC1 \| Exo70p \| FLJ40965 \| FLJ46415 \| YJL085W	exocyst complex component 7	-	HPRD	11406615
EXOC8	EXO84 \| Exo84p \| SEC84	exocyst complex component 8	-	HPRD,BioGRID	14525976
FLNA	ABP-280 \| ABPX \| DKFZp434P031 \| FLN \| FLN1 \| FMD \| MNS \| NHBP \| OPD \| OPD1 \| OPD2	filamin A, alpha (actin binding protein 280)	-	HPRD,BioGRID	10051605
HRAS	C-BAS/HAS \| C-H-RAS \| C-HA-RAS1 \| CTLO \| H-RASIDX \| HAMSV \| HRAS1 \| K-RAS \| N-RAS \| RASH1	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	Two-hybrid	BioGRID	11786539
LRPAP1	A2MRAP \| A2RAP \| HBP44 \| MGC138272 \| MRAP \| RAP	low density lipoprotein receptor-related protein associated protein 1	Reconstituted Complex	BioGRID	11167825
PLD1	-	phospholipase D1, phosphatidylcholine-specific	-	HPRD,BioGRID	9207251
RAB8B	FLJ38125	RAB8B, member RAS oncogene family	-	HPRD	10889189
RALBP1	RIP1 \| RLIP1 \| RLIP76	ralA binding protein 1	-	HPRD,BioGRID	7673236
RALBP1	RIP1 \| RLIP1 \| RLIP76	ralA binding protein 1	RalA interacts with RalBP1.	BIND	15592429
RALBP1	RIP1 \| RLIP1 \| RLIP76	ralA binding protein 1	RalA interacts with RLIP76.	BIND	7673236
RALGPS1	KIAA0351 \| RALGEF2 \| RALGPS1A	Ral GEF with PH domain and SH3 binding motif 1	-	HPRD,BioGRID	10889189
RAP1A	KREV-1 \| KREV1 \| RAP1 \| SMGP21	RAP1A, member of RAS oncogene family	Two-hybrid	BioGRID	11786539
RAP2A	K-REV \| KREV \| RAP2 \| RbBP-30	RAP2A, member of RAS oncogene family	Two-hybrid	BioGRID	11786539
RAP2B	MGC20484	RAP2B, member of RAS oncogene family	Two-hybrid	BioGRID	11786539
RGL2	HKE1.5 \| KE1.5 \| RAB2L	ral guanine nucleotide dissociation stimulator-like 2	Two-hybrid	BioGRID	8939933
RGL4	MGC119678 \| MGC119680 \| Rgr	ral guanine nucleotide dissociation stimulator-like 4	-	HPRD,BioGRID	12874025
TSC2	FLJ43106 \| LAM \| TSC4	tuberous sclerosis 2	Affinity Capture-Western	BioGRID	12842888

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER	70	56	All SZGR 2.0 genes in this pathway
BIOCARTA RAS PATHWAY	23	20	All SZGR 2.0 genes in this pathway
ST INTEGRIN SIGNALING PATHWAY	82	62	All SZGR 2.0 genes in this pathway
PID ARF6 TRAFFICKING PATHWAY	49	34	All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA PATHWAY	31	25	All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY	49	43	All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY	105	78	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO RAS	27	23	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO ERKS	36	30	All SZGR 2.0 genes in this pathway
REACTOME P38MAPK EVENTS	13	12	All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS TOP50 UP	38	27	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP	473	314	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS RED DN	25	19	All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP	265	158	All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 UP	137	84	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP	584	356	All SZGR 2.0 genes in this pathway
CHOI ATL STAGE PREDICTOR	44	24	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE AUGMENTED BY MYC	108	74	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
OXFORD RALA TARGETS DN	10	8	All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN	160	110	All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6	144	98	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
STOSSI RESPONSE TO ESTRADIOL	50	35	All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A DN	76	57	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS	108	71	All SZGR 2.0 genes in this pathway
MCCLUNG CREB1 TARGETS UP	100	72	All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 3HR	74	47	All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP	388	234	All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN	353	226	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN	270	181	All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY UP	134	84	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP	245	159	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN	175	103	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS	535	325	All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP	221	135	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 10	69	38	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
VANOEVELEN MYOGENESIS SIN3A TARGETS	220	133	All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL UP	146	75	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	1462	1468	1A	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-124.1	594	601	1A,m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	594	600	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	594	600	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-153	452	458	1A	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-181	238	245	1A,m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-183	772	779	1A,m8	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-221/222	241	247	m8	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
miR-221/222	241	247	m8	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-24	1838	1844	1A	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-27	519	525	1A	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	519	525	1A	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-29	1760	1766	1A	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-30-3p	79	85	m8	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
miR-30-3p	79	85	m8	hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-329	638	644	m8	hsa-miR-329^brain	AACACACCUGGUUAACCUCUUU
miR-34b	389	395	m8	hsa-miR-34b	UAGGCAGUGUCAUUAGCUGAUUG
miR-369-3p	341	347	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	341	348	1A,m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-376	1764	1770	1A	hsa-miR-376a	AUCAUAGAGGAAAAUCCACGU
miR-376	1764	1770	1A	hsa-miR-376b	AUCAUAGAGGAAAAUCCAUGUU
miR-448	452	458	1A	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: RALA