Gene Page: RGR
Summary ?
| GeneID | 5995 |
| Symbol | RGR |
| Synonyms | RP44 |
| Description | retinal G protein coupled receptor |
| Reference | MIM:600342|HGNC:HGNC:9990|Ensembl:ENSG00000148604|HPRD:02642| |
| Gene type | protein-coding |
| Map location | 10q23 |
| Pascal p-value | 0.057 |
| Fetal beta | -1.245 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg06705986 | 10 | 86004888 | RGR | 3.714E-4 | -0.556 | 0.043 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10736319 | 10 | 86004238 | RGR | ENSG00000148604.9 | 4.91674E-9 | 0 | -571 | gtex_brain_ba24 |
| rs2279228 | 10 | 86004736 | RGR | ENSG00000148604.9 | 4.91674E-9 | 0 | -73 | gtex_brain_ba24 |
| rs2279227 | 10 | 86004873 | RGR | ENSG00000148604.9 | 4.91674E-9 | 0 | 64 | gtex_brain_ba24 |
| rs10736319 | 10 | 86004238 | RGR | ENSG00000148604.9 | 9.48326E-12 | 0 | -571 | gtex_brain_putamen_basal |
| rs2279228 | 10 | 86004736 | RGR | ENSG00000148604.9 | 9.48326E-12 | 0 | -73 | gtex_brain_putamen_basal |
| rs2279227 | 10 | 86004873 | RGR | ENSG00000148604.9 | 9.48326E-12 | 0 | 64 | gtex_brain_putamen_basal |
| rs3526 | 10 | 86018460 | RGR | ENSG00000148604.9 | 1.25257E-7 | 0 | 13651 | gtex_brain_putamen_basal |
| rs398114579 | 10 | 86019089 | RGR | ENSG00000148604.9 | 4.02085E-8 | 0 | 14280 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME SIGNALING BY GPCR | 920 | 449 | All SZGR 2.0 genes in this pathway |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | 305 | 177 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR DOWNSTREAM SIGNALING | 805 | 368 | All SZGR 2.0 genes in this pathway |
| REACTOME G ALPHA I SIGNALLING EVENTS | 195 | 114 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR LIGAND BINDING | 408 | 246 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS DN | 357 | 212 | All SZGR 2.0 genes in this pathway |
| KIM GASTRIC CANCER CHEMOSENSITIVITY | 103 | 64 | All SZGR 2.0 genes in this pathway |
| BANDRES RESPONSE TO CARMUSTIN MGMT 24HR DN | 33 | 21 | All SZGR 2.0 genes in this pathway |
| WANG CISPLATIN RESPONSE AND XPC UP | 202 | 115 | All SZGR 2.0 genes in this pathway |
| BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN | 161 | 105 | All SZGR 2.0 genes in this pathway |