Gene Page: RP1

Summary ?
GeneID6101
SymbolRP1
SynonymsDCDC4A|ORP1
Descriptionretinitis pigmentosa 1 (autosomal dominant)
ReferenceMIM:603937|HGNC:HGNC:10263|Ensembl:ENSG00000104237|HPRD:04896|Vega:OTTHUMG00000164379
Gene typeprotein-coding
Map location8q12.1
Pascal p-value0.002

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
RP1chr855538878TCNM_006269.silentSchizophreniaDNM:Fromer_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TIMM8B0.730.59
RBX10.680.52
RPS10L0.680.53
AC009171.10.680.51
AC010468.10.680.54
COX7A20.670.49
PFDN50.670.61
RPL10AP30.670.45
MRPS280.660.49
NDUFB70.650.36
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PLEC1-0.49-0.57
TECPR2-0.46-0.48
MYH9-0.46-0.48
AGPAT3-0.45-0.46
ZBTB47-0.44-0.52
FICD-0.44-0.47
MAFK-0.44-0.56
ACTN4-0.42-0.49
SYNM-0.42-0.51
JAKMIP3-0.42-0.48

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
LIAN LIPA TARGETS 6M 7447All SZGR 2.0 genes in this pathway
HARRIS HYPOXIA 8164All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway