Gene Page: ACOT1
Summary ?
| GeneID | 641371 |
| Symbol | ACOT1 |
| Synonyms | ACH2|CTE-1|LACH2 |
| Description | acyl-CoA thioesterase 1 |
| Reference | MIM:614313|HGNC:HGNC:33128|Ensembl:ENSG00000184227|Vega:OTTHUMG00000171607 |
| Gene type | protein-coding |
| Map location | 14q24.3 |
| Pascal p-value | 0.032 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs9788526 | 14 | 74031492 | ACOT1 | ENSG00000184227.3 | 3.671E-7 | 0 | 27674 | gtex_brain_ba24 |
| rs8018231 | 14 | 74034190 | ACOT1 | ENSG00000184227.3 | 6.293E-8 | 0 | 30372 | gtex_brain_ba24 |
| rs11545737 | 14 | 74035671 | ACOT1 | ENSG00000184227.3 | 3.148E-7 | 0 | 31853 | gtex_brain_ba24 |
| rs398039233 | 14 | 74036674 | ACOT1 | ENSG00000184227.3 | 1.637E-7 | 0 | 32856 | gtex_brain_ba24 |
| rs143643216 | 14 | 74037679 | ACOT1 | ENSG00000184227.3 | 2.968E-7 | 0 | 33861 | gtex_brain_ba24 |
| rs71429008 | 14 | 74037730 | ACOT1 | ENSG00000184227.3 | 2.727E-7 | 0 | 33912 | gtex_brain_ba24 |
| rs12433922 | 14 | 74038071 | ACOT1 | ENSG00000184227.3 | 1.246E-7 | 0 | 34253 | gtex_brain_ba24 |
| rs10138390 | 14 | 74184530 | ACOT1 | ENSG00000184227.3 | 5.558E-7 | 0 | 180712 | gtex_brain_ba24 |
| rs79547755 | 14 | 74185345 | ACOT1 | ENSG00000184227.3 | 5.558E-7 | 0 | 181527 | gtex_brain_ba24 |
| rs79875771 | 14 | 74186273 | ACOT1 | ENSG00000184227.3 | 5.469E-7 | 0 | 182455 | gtex_brain_ba24 |
| rs79442823 | 14 | 74186827 | ACOT1 | ENSG00000184227.3 | 5.558E-7 | 0 | 183009 | gtex_brain_ba24 |
| rs2075024 | 14 | 74197163 | ACOT1 | ENSG00000184227.3 | 3.713E-6 | 0 | 193345 | gtex_brain_ba24 |
| rs758772 | 14 | 74206847 | ACOT1 | ENSG00000184227.3 | 3.713E-6 | 0 | 203029 | gtex_brain_ba24 |
| rs8009266 | 14 | 74207345 | ACOT1 | ENSG00000184227.3 | 3.713E-6 | 0 | 203527 | gtex_brain_ba24 |
| rs17782146 | 14 | 74208662 | ACOT1 | ENSG00000184227.3 | 2.576E-6 | 0 | 204844 | gtex_brain_ba24 |
| rs74959857 | 14 | 74209094 | ACOT1 | ENSG00000184227.3 | 3.353E-6 | 0 | 205276 | gtex_brain_ba24 |
| rs4417498 | 14 | 74030027 | ACOT1 | ENSG00000184227.3 | 2.705E-6 | 0 | 26209 | gtex_brain_putamen_basal |
| rs8018231 | 14 | 74034190 | ACOT1 | ENSG00000184227.3 | 3.12E-7 | 0 | 30372 | gtex_brain_putamen_basal |
| rs398039233 | 14 | 74036674 | ACOT1 | ENSG00000184227.3 | 9.904E-7 | 0 | 32856 | gtex_brain_putamen_basal |
| rs143643216 | 14 | 74037679 | ACOT1 | ENSG00000184227.3 | 1.245E-8 | 0 | 33861 | gtex_brain_putamen_basal |
| rs12433922 | 14 | 74038071 | ACOT1 | ENSG00000184227.3 | 1.057E-8 | 0 | 34253 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG BIOSYNTHESIS OF UNSATURATED FATTY ACIDS | 22 | 12 | All SZGR 2.0 genes in this pathway |
| FUJIWARA PARK2 HEPATOCYTE PROLIFERATION DN | 8 | 7 | All SZGR 2.0 genes in this pathway |
| CAMPS COLON CANCER COPY NUMBER DN | 74 | 34 | All SZGR 2.0 genes in this pathway |
| OHGUCHI LIVER HNF4A TARGETS UP | 44 | 30 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 UP | 344 | 215 | All SZGR 2.0 genes in this pathway |
| SERVITJA LIVER HNF1A TARGETS UP | 135 | 96 | All SZGR 2.0 genes in this pathway |