Gene Page: TAF1
Summary ?
| GeneID | 6872 |
| Symbol | TAF1 |
| Synonyms | BA2R|CCG1|CCGS|DYT3|DYT3/TAF1|KAT4|MRXS33|N-TAF1|NSCL2|OF|P250|TAF(II)250|TAF2A|TAFII-250|TAFII250|XDP |
| Description | TATA-box binding protein associated factor 1 |
| Reference | MIM:313650|HGNC:HGNC:11535|Ensembl:ENSG00000147133|HPRD:02436|Vega:OTTHUMG00000022723 |
| Gene type | protein-coding |
| Map location | Xq13.1 |
| Fetal beta | 0.676 |
| Support | Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ASF1A | CGI-98 | CIA | DKFZp547E2110 | HSPC146 | ASF1 anti-silencing function 1 homolog A (S. cerevisiae) | - | HPRD | 12093919 |
| ASF1A | CGI-98 | CIA | DKFZp547E2110 | HSPC146 | ASF1 anti-silencing function 1 homolog A (S. cerevisiae) | CIA interacts with TAFII250. | BIND | 12093919 |
| ASF1B | CIA-II | FLJ10604 | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) | - | HPRD | 12842904 |
| BAX | BCL2L4 | BCL2-associated X protein | TAF1 (TAFII250) interacts with the Bax promoter. | BIND | 15710329 |
| CCNA2 | CCN1 | CCNA | cyclin A2 | - | HPRD,BioGRID | 9660973 |
| CCND1 | BCL1 | D11S287E | PRAD1 | U21B31 | cyclin D1 | TAFII250 interacts with Cyclin D1. This interaction was modelled on a demonstrated interaction between TAFII250 from human and Cyclin D1 from mouse. | BIND | 11126356 |
| CCND1 | BCL1 | D11S287E | PRAD1 | U21B31 | cyclin D1 | - | HPRD,BioGRID | 9926939 |11126356 |
| EDF1 | EDF-1 | MBF1 | MGC9058 | endothelial differentiation-related factor 1 | - | HPRD | 12040021 |
| EWSR1 | EWS | Ewing sarcoma breakpoint region 1 | - | HPRD | 9488465 |
| FOS | AP-1 | C-FOS | v-fos FBJ murine osteosarcoma viral oncogene homolog | - | HPRD,BioGRID | 8065335 |
| GTF2A1 | MGC129969 | MGC129970 | TF2A1 | TFIIA | general transcription factor IIA, 1, 19/37kDa | - | HPRD,BioGRID | 11278496 |
| GTF2B | TF2B | TFIIB | general transcription factor IIB | - | HPRD | 1876184 |
| GTF2E1 | FE | TF2E1 | TFIIE-A | general transcription factor IIE, polypeptide 1, alpha 56kDa | Reconstituted Complex | BioGRID | 7926747 |
| GTF2F1 | BTF4 | RAP74 | TF2F1 | TFIIF | general transcription factor IIF, polypeptide 1, 74kDa | Biochemical Activity in vitro in vivo Reconstituted Complex | BioGRID | 7590250 |8625415 |9482861 |9660973 |9858607 |
| GTF2F1 | BTF4 | RAP74 | TF2F1 | TFIIF | general transcription factor IIF, polypeptide 1, 74kDa | - | HPRD | 7590250 |8625415 |9660973 |10428810 |
| HIST3H3 | H3.4 | H3/g | H3FT | H3t | MGC126886 | MGC126888 | histone cluster 3, H3 | - | HPRD | 8980232 |
| HMGB1 | DKFZp686A04236 | HMG1 | HMG3 | SBP-1 | high-mobility group box 1 | - | HPRD | 9880542 |
| HSF1 | HSTF1 | heat shock transcription factor 1 | - | HPRD | 11005381 |
| JUN | AP-1 | AP1 | c-Jun | jun oncogene | - | HPRD,BioGRID | 11316804 |
| MDM2 | HDMX | MGC71221 | hdm2 | Mdm2 p53 binding protein homolog (mouse) | - | HPRD,BioGRID | 9388200 |
| MSX1 | HOX7 | HYD1 | msh homeobox 1 | - | HPRD,BioGRID | 8700832 |
| PAX6 | AN | AN2 | D11S812E | MGC17209 | MGDA | WAGR | paired box 6 | Affinity Capture-Western | BioGRID | 10359315 |
| RB1 | OSRC | RB | p105-Rb | pRb | pp110 | retinoblastoma 1 | TAFII250 interacts with Rb. | BIND | 11126356 |
| RB1 | OSRC | RB | p105-Rb | pRb | pp110 | retinoblastoma 1 | - | HPRD,BioGRID | 7724524 |9242374 |9858607 |
| RBL1 | CP107 | MGC40006 | PRB1 | p107 | retinoblastoma-like 1 (p107) | - | HPRD,BioGRID | 9242374 |
| RBL2 | FLJ26459 | P130 | Rb2 | retinoblastoma-like 2 (p130) | - | HPRD,BioGRID | 9242374 |
| RELA | MGC131774 | NFKB3 | p65 | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | - | HPRD,BioGRID | 9584164 |
| SUB1 | MGC102747 | P15 | PC4 | p14 | SUB1 homolog (S. cerevisiae) | - | HPRD | 9482861 |
| TAF1 | BA2R | CCG1 | CCGS | DYT3 | KAT4 | N-TAF1 | NSCL2 | OF | P250 | TAF2A | TAFII250 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | - | HPRD | 8650542 |
| TAF10 | TAF2A | TAF2H | TAFII30 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa | - | HPRD | 7923369 |
| TAF15 | Npl3 | RBP56 | TAF2N | TAFII68 | hTAFII68 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | - | HPRD | 8663456 |9488465 |
| TAF2 | CIF150 | TAF2B | TAFII150 | TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa | - | HPRD,BioGRID | 10469661 |
| TAF4 | FLJ41943 | TAF2C | TAF2C1 | TAF4A | TAFII130 | TAFII135 | TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa | - | HPRD,BioGRID | 11564872 |
| TAF4B | TAF2C2 | TAFII105 | TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa | TAF4B (hTAF4b) interacts with an uspecified isoform of TAF1 (hTAF1). | BIND | 15601843 |
| TAF5 | TAF2D | TAFII100 | TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa | - | HPRD,BioGRID | 9045704 |
| TAF6 | DKFZp781E21155 | MGC:8964 | TAF2E | TAFII70 | TAFII80 | TAFII85 | TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa | - | HPRD,BioGRID | 7667268 |
| TAF7 | TAF2F | TAFII55 | TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa | - | HPRD,BioGRID | 11592977 |
| TAF7L | FLJ23157 | TAF2Q | dJ738A13.1 | TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa | Two-hybrid | BioGRID | 12665565 |
| TAF8 | 43 | FLJ32821 | II | TAF | TAFII43 | TBN | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa | - | HPRD | 14580349 |
| TBP | GTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIID | TATA box binding protein | - | HPRD,BioGRID | 7680771 |
| TP53 | FLJ92943 | LFS1 | TRP53 | p53 | tumor protein p53 | - | HPRD | 7809597 |
| TP53 | FLJ92943 | LFS1 | TRP53 | p53 | tumor protein p53 | Affinity Capture-Western | BioGRID | 10359315 |
| UBTF | NOR-90 | UBF | upstream binding transcription factor, RNA polymerase I | - | HPRD,BioGRID | 12498690 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG BASAL TRANSCRIPTION FACTORS | 36 | 24 | All SZGR 2.0 genes in this pathway |
| BIOCARTA P53HYPOXIA PATHWAY | 23 | 21 | All SZGR 2.0 genes in this pathway |
| PID RB 1PATHWAY | 65 | 46 | All SZGR 2.0 genes in this pathway |
| REACTOME RNA POL II TRANSCRIPTION | 105 | 54 | All SZGR 2.0 genes in this pathway |
| REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | 41 | 21 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSCRIPTION | 210 | 127 | All SZGR 2.0 genes in this pathway |
| REACTOME RNA POL II PRE TRANSCRIPTION EVENTS | 61 | 32 | All SZGR 2.0 genes in this pathway |
| REACTOME HIV INFECTION | 207 | 122 | All SZGR 2.0 genes in this pathway |
| REACTOME HIV LIFE CYCLE | 125 | 69 | All SZGR 2.0 genes in this pathway |
| REACTOME LATE PHASE OF HIV LIFE CYCLE | 104 | 61 | All SZGR 2.0 genes in this pathway |
| GARY CD5 TARGETS UP | 473 | 314 | All SZGR 2.0 genes in this pathway |
| WANG CLIM2 TARGETS UP | 269 | 146 | All SZGR 2.0 genes in this pathway |
| GINESTIER BREAST CANCER 20Q13 AMPLIFICATION UP | 119 | 66 | All SZGR 2.0 genes in this pathway |
| ODONNELL METASTASIS UP | 82 | 58 | All SZGR 2.0 genes in this pathway |
| GRUETZMANN PANCREATIC CANCER DN | 203 | 134 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 6HR DN | 514 | 330 | All SZGR 2.0 genes in this pathway |
| TARTE PLASMA CELL VS PLASMABLAST UP | 398 | 262 | All SZGR 2.0 genes in this pathway |
| HOFMANN CELL LYMPHOMA DN | 39 | 29 | All SZGR 2.0 genes in this pathway |
| YAGI AML SURVIVAL | 129 | 87 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| HEDENFALK BREAST CANCER BRCA1 VS BRCA2 | 163 | 113 | All SZGR 2.0 genes in this pathway |
| SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 | 419 | 273 | All SZGR 2.0 genes in this pathway |
| FIRESTEIN PROLIFERATION | 175 | 125 | All SZGR 2.0 genes in this pathway |
| YAGI AML WITH INV 16 TRANSLOCATION | 422 | 277 | All SZGR 2.0 genes in this pathway |
| GABRIELY MIR21 TARGETS | 289 | 187 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP D | 280 | 158 | All SZGR 2.0 genes in this pathway |