Gene Page: BTK

Summary
GeneID  695
Symbol  BTK
Synonyms  AGMX1|AT|ATK|BPK|IMD1|MGC126261|MGC126262|PSCTK1|XLA
Description  Bruton agammaglobulinemia tyrosine kinase
See related  HGNC:1133|MIM:300300|Ensembl:ENSG00000010671|HPRD:02248|
Locus tag  RP1-164F3.2
Gene type  protein-coding
Map location  Xq21.33-q22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1022 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NUSAP10.990.85
TPX20.990.83
KIF4A0.990.84
BUB1B0.990.86
CCNB20.990.87
MELK0.990.84
KIF230.990.80
PRC10.980.66
CCNA20.980.84
EXO10.980.78
Top 10 negatively co-expressed genes
SLC9A3R2-0.40-0.55
FBXO2-0.40-0.71
HLA-F-0.39-0.77
PTH1R-0.39-0.71
C5orf53-0.39-0.69
ASPHD1-0.38-0.59
TNFSF12-0.38-0.68
ALDOC-0.38-0.73
LHPP-0.38-0.63
AIFM3-0.37-0.72
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIEA-
GO:0005524ATP bindingIEA-
GO:0005524ATP bindingTAS11913944 
GO:0004713protein tyrosine kinase activityIEA-
GO:0004715non-membrane spanning protein tyrosine kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0016301kinase activityIEA-
GO:0042802identical protein bindingIPI11577348 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationIEA-
GO:0007242intracellular signaling cascadeIEA-
GO:0007242intracellular signaling cascadeTAS11913944 
GO:0007498mesoderm developmentTAS8013627 
GO:0007249I-kappaB kinase/NF-kappaB cascadeIEA-
GO:0008624induction of apoptosis by extracellular signalsTAS8688094 
GO:0019722calcium-mediated signalingTAS15046600 
GO:0018108peptidyl-tyrosine phosphorylationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA18029348 
GO:0005634nucleusIEA-
GO:0005737cytoplasmIDA18029348 
GO:0005737cytoplasmTAS15046600 
GO:0016020membraneIEA-
GO:0031410cytoplasmic vesicleIEA-
GO:0045121membrane raftIDA15046600 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARHGAP17DKFZp564A1363 | FLJ37567 | FLJ43368 | MGC87805 | MST066 | MST110 | MSTP038 | MSTP066 | MSTP110 | NADRIN | RICH1 | WBP15Rho GTPase activating protein 17Reconstituted ComplexBioGRID11431473 
ARID3ABRIGHT | DRIL1 | DRIL3 | E2FBP1AT rich interactive domain 3A (BRIGHT-like)-HPRD,BioGRID15203319 
BLNKBASH | BLNK-S | LY57 | MGC111051 | SLP-65 | SLP65B-cell linker-HPRD10498607 |10556826 
Affinity Capture-Western
in vitro
in vivo		BioGRID10498607 |12093870 
BTKAGMX1 | AT | ATK | BPK | IMD1 | MGC126261 | MGC126262 | PSCTK1 | XLABruton agammaglobulinemia tyrosine kinase-HPRD,BioGRID11527964 
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDa-HPRD,BioGRID11751885 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequence-HPRD,BioGRID7629518 |10427990 
CBLBDKFZp686J10223 | DKFZp779A0729 | DKFZp779F1443 | FLJ36865 | FLJ41152 | Nbla00127 | RNF56Cas-Br-M (murine) ecotropic retroviral transforming sequence bAffinity Capture-WesternBioGRID12093870 
EWSR1EWSEwing sarcoma breakpoint region 1-HPRD,BioGRID9201297 
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)-HPRD9751072 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YESReconstituted ComplexBioGRID8058772 
GNA12MGC104623 | MGC99644 | NNX3 | RMP | gepguanine nucleotide binding protein (G protein) alpha 12in vitro
in vivo		BioGRID9796816 
GNAQG-ALPHA-q | GAQguanine nucleotide binding protein (G protein), q polypeptide-HPRD,BioGRID9770463 
GNG2-guanine nucleotide binding protein (G protein), gamma 2-HPRD7972043 |11698416 
GTF2IBAP-135 | BAP135 | BTKAP1 | DIWS | FLJ38776 | FLJ56355 | IB291 | SPIN | TFII-I | WBS | WBSCR6general transcription factor II, i-HPRD,BioGRID9012831 |10373551 
|14623887 
HCKJTK9hemopoietic cell kinase-HPRD,BioGRID8058772 
IBTKBTKI | KIAA1417 | MGC142256 | MGC142258 | RP1-93K22.1inhibitor of Bruton agammaglobulinemia tyrosine kinase-HPRD,BioGRID11577348 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)-HPRD,BioGRID9178903 
KHDRBS1FLJ34027 | Sam68 | p62KH domain containing, RNA binding, signal transduction associated 1-HPRD,BioGRID9201297 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homolog-HPRD,BioGRID8058772 
PLCG2-phospholipase C, gamma 2 (phosphatidylinositol-specific)Affinity Capture-WesternBioGRID10981967 |12093870 
PRKCBMGC41878 | PKC-beta | PKCB | PRKCB1 | PRKCB2protein kinase C, betaReconstituted ComplexBioGRID12679936 
PRKD1PKC-MU | PKCM | PKD | PRKCMprotein kinase D1-HPRD,BioGRID10561498 
RPS6KB1PS6K | S6K | S6K1 | STK14A | p70(S6K)-alpha | p70-S6K | p70-alpharibosomal protein S6 kinase, 70kDa, polypeptide 1Biochemical ActivityBioGRID16640565 
RPS6KB2KLS | P70-beta | P70-beta-1 | P70-beta-2 | S6K-beta2 | S6K2 | SRK | STK14B | p70(S6K)-beta | p70S6Kbribosomal protein S6 kinase, 70kDa, polypeptide 2Biochemical ActivityBioGRID16640565 
SH2B2APSSH2B adaptor protein 2-HPRD10872802 
SH3BP5SABSH3-domain binding protein 5 (BTK-associated)-HPRD,BioGRID9571151 
-HPRD9571151 |10339589 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD,BioGRID9201297 
WASIMD2 | THC | WASPWiskott-Aldrich syndrome (eczema-thrombocytopenia)-HPRD,BioGRID8892607 
WASF2SCAR2 | WAVE2 | dJ393P12.2WAS protein family, member 2-HPRD10427990 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 7556All SZGR genes in this pathway
KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 7958All SZGR genes in this pathway
KEGG_PRIMARY_IMMUNODEFICIENCY 3528All SZGR genes in this pathway
BIOCARTA_BCR_PATHWAY 3728All SZGR genes in this pathway
BIOCARTA_FCER1_PATHWAY 4130All SZGR genes in this pathway
BIOCARTA_PTDINS_PATHWAY 2316All SZGR genes in this pathway
ST_GA12_PATHWAY 2316All SZGR genes in this pathway
SIG_CHEMOTAXIS 4537All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES 3631All SZGR genes in this pathway
SIG_BCR_SIGNALING_PATHWAY 4638All SZGR genes in this pathway
ST_B_CELL_ANTIGEN_RECEPTOR 4032All SZGR genes in this pathway
ST_FAS_SIGNALING_PATHWAY 6554All SZGR genes in this pathway
ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY 3729All SZGR genes in this pathway
PID_FCER1_PATHWAY 6243All SZGR genes in this pathway
PID_BCR_5PATHWAY 6550All SZGR genes in this pathway
PID_FAS_PATHWAY 3829All SZGR genes in this pathway
PID_PI3KCI_PATHWAY 4940All SZGR genes in this pathway
PID_EPO_PATHWAY 3429All SZGR genes in this pathway
REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS 2924All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 12690All SZGR genes in this pathway
REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 8363All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_ACTIVATED_TLR4_SIGNALLING 9369All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_TOLL_RECEPTOR_CASCADES 11884All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_UP 201125All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
HOEBEKE_LYMPHOID_STEM_CELL_UP 9564All SZGR genes in this pathway
KLEIN_TARGETS_OF_BCR_ABL1_FUSION 4534All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_DN 12479All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_DN 245154All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN 337230All SZGR genes in this pathway
LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP 7451All SZGR genes in this pathway
FINETTI_BREAST_CANCER_KINOME_GREEN 1614All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_UP 10264All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
VILIMAS_NOTCH1_TARGETS_DN 2012All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_UP 288168All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway


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