Gene Page: TFAP2A

Summary
GeneID  7020
Symbol  TFAP2A
Synonyms  AP-2|AP-2alpha|AP2TF|BOFS|TFAP2
Description  transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
See related  HGNC:11742|MIM:107580|Ensembl:ENSG00000137203|HPRD:00128|
Locus tag  -
Gene type  protein-coding
Map location  6p24
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0159 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0839 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
C6orf270.730.68
MYH7B0.710.61
SLC9A10.710.67
KCNC10.710.66
KNDC10.700.63
OGDHL0.700.58
AC011676.20.700.62
NCKIPSD0.690.62
EML20.690.59
ABLIM20.690.61
Top 10 negatively co-expressed genes
PFDN5-0.44-0.54
RPL31-0.43-0.55
RPL35-0.43-0.56
RPS7-0.42-0.50
PRDX4-0.42-0.49
RPL12-0.42-0.52
RPS18-0.41-0.51
C9orf46-0.41-0.48
RPL27-0.40-0.51
RAMP2-0.40-0.46
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0003700transcription factor activityNAS1916817 
GO:0003713transcription coactivator activityTAS8321221 
GO:0046983protein dimerization activityIDA12072434 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006357regulation of transcription from RNA polymerase II promoterTAS8321221 
GO:0006350transcriptionIEA-
GO:0007398ectoderm developmentTAS8661133 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005634nucleusIMP12586840 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APCBTPS2 | DP2 | DP2.5 | DP3 | GSadenomatous polyposis coliAffinity Capture-Western
Reconstituted Complex		BioGRID15331612 
CITED2MRG1 | P35SRJCbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2-HPRD,BioGRID12586840 
CITED4-Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4-HPRD,BioGRID11744733 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaAffinity Capture-WesternBioGRID15331612 
DEKD6S231EDEK oncogene-HPRD,BioGRID12595566 
EP300KAT3B | p300E1A binding protein p300-HPRD,BioGRID12586840 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Affinity Capture-MSBioGRID12577067 
LDLRAP1ARH | ARH1 | ARH2 | DKFZp586D0624 | FHCB1 | FHCB2 | MGC34705low density lipoprotein receptor adaptor protein 1-HPRD12221107 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Affinity Capture-Western
Reconstituted Complex		BioGRID7729426 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53p53 interacts with AP2alpha.BIND12226108 
-HPRD,BioGRID12226108 
WWP2AIP2 | WWp2-likeWW domain containing E3 ubiquitin protein ligase 2-HPRD9169421 
YBX1BP-8 | CSDA2 | CSDB | DBPB | MDR-NF1 | MGC104858 | MGC110976 | MGC117250 | NSEP-1 | NSEP1 | YB-1 | YB1Y box binding protein 1-HPRD,BioGRID9830047 |11973333 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_CASPASE_PATHWAY 5239All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
WATANABE_COLON_CANCER_MSI_VS_MSS_UP 2918All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_GREY_DN 7444All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_UP 14699All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_UP 14984All SZGR genes in this pathway
TOMIDA_METASTASIS_UP 2613All SZGR genes in this pathway
WONG_ENDMETRIUM_CANCER_UP 2517All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5 14789All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
TERAMOTO_OPN_TARGETS_CLUSTER_7 1916All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
BERTUCCI_INVASIVE_CARCINOMA_DUCTAL_VS_LOBULAR_UP 2517All SZGR genes in this pathway
FRIDMAN_SENESCENCE_UP 7760All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
CERVERA_SDHB_TARGETS_2 11476All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
SASAKI_ADULT_T_CELL_LEUKEMIA 176122All SZGR genes in this pathway
HOFMANN_CELL_LYMPHOMA_UP 5035All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
RORIE_TARGETS_OF_EWSR1_FLI1_FUSION_UP 3022All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_UP 8961All SZGR genes in this pathway
NGUYEN_NOTCH1_TARGETS_DN 8667All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C2 5439All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
ZHU_CMV_8_HR_DN 5340All SZGR genes in this pathway
ZHU_CMV_ALL_DN 12893All SZGR genes in this pathway
LOPES_METHYLATED_IN_COLON_CANCER_DN 2826All SZGR genes in this pathway
JI_CARCINOGENESIS_BY_KRAS_AND_STK11_UP 127All SZGR genes in this pathway
AMUNDSON_POOR_SURVIVAL_AFTER_GAMMA_RADIATION_8G 9562All SZGR genes in this pathway
HOQUE_METHYLATED_IN_CANCER 5645All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_UP 12692All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12 317177All SZGR genes in this pathway
MIKKELSEN_PARTIALLY_REPROGRAMMED_TO_PLURIPOTENCY 106All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_DN 210141All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 210148All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_G2 182102All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_DN 428246All SZGR genes in this pathway
DURAND_STROMA_S_UP 297194All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-10154015461Ahsa-miR-10aUACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10bUACCCUGUAGAACCGAAUUUGU
miR-1354784841Ahsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-141/200a668674m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-15/16/195/424/497109115m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-18616051611m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-200bc/429530536m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-204/2116606661Ahsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-25/32/92/363/367146914751Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-265455511Ahsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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